Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Lesley Marson"'
Autor:
Alan W. Shindel, MD, MAS, Michael Krychman, MD, Rose Hartzell-Cushanick, PhD, EdS, CHES, LMFT, Sophie Bergeron, PhD, Lesley Marson, PhD
Publikováno v:
Sexual Medicine, Vol 3, Iss 2, Pp 55-61 (2015)
Externí odkaz:
https://doaj.org/article/495c3c409c684f43be0ff22e366b02b0
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 101:171-179
The feasibility of eliciting defecation and urination after intranasal (IN) or sublingual (SL) delivery of a small peptide NK2 receptor agonist, [Lys5, MeLeu9, Nle10]-NKA(4–10), was examined using prototype formulations in dogs. In anesthetized ani
Publikováno v:
J Basic Clin Physiol Pharmacol
Objectives Neurokinin 2 receptor (NK2R) agonists may be useful for treating bladder and bowel dysfunction via direct contraction of detrusor and gastrointestinal smooth muscle. The NK2R agonist [Lys5, MeLeu9, Nle10]-NKA(4–10) (LMN-NKA) induces urin
Publikováno v:
Spinal Cord. 59:1013-1017
STUDY DESIGN Animal proof of principle study. OBJECTIVES Bladder and bowel dysfunction are common after spinal cord injury (SCI) and in the elderly. Neurokinin 2 receptor agonists are known to produce on-demand urination and defecation in adult SCI r
Publikováno v:
Spinal cord. 59(9)
Animal proof of principle study.Bladder and bowel dysfunction are common after spinal cord injury (SCI) and in the elderly. Neurokinin 2 receptor agonists are known to produce on-demand urination and defecation in adult SCI rats. This study compared
Publikováno v:
Journal of comparative psychology (Washington, D.C. : 1983). 135(1)
Oxytocin has been shown to be important for social behavior and emotional attachments in early life and may also mediate effects of early experiences on social motivation in adulthood. In animal models, early maternal separation results in alteration
Publikováno v:
J Neurotrauma
Acute administration of [Lys5,Me,Leu9,Nle10]-NKA(4-10) (LMN-NKA) produces contractions of the detrusor and rectum with voiding in intact and acutely spinal cord injured (SCI) rats. In the current study, the ability of LMN-NKA (10 μg/kg or 100 μg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b624531955c535c2e072c1fa03c76f84
https://europepmc.org/articles/PMC7071061/
https://europepmc.org/articles/PMC7071061/
Autor:
Marcalee Alexander, Lesley Marson
Publikováno v:
Autonomic Neuroscience. 209:90-99
Preclinical research in animal models is important for understanding the neural pathways and pathophysiology underlying changes in sexual function after SCI. In vivo animal models, primarily rodents, have provided valuable information on the central
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 390:163-173
The purpose of this study was to determine feasibility of a novel therapeutic approach to drug-induced voiding after spinal cord injury (SCI) using a well-characterized, peptide, neurokinin 2 receptor (NK2 receptor) agonist, Lys5, MeLeu9, Nle10-NKA(4
Autor:
Nadia M J, Rupniak, Mary A, Katofiasc, Lesley, Marson, Daniel J, Ricca, Karl B, Thor, Edward C, Burgard
Publikováno v:
Neuropeptides
The effects of the neurokinin NK2 receptor agonist [Lys(5),MeLeu(9),Nle(10)]-NKA((4–10)) (LMN-NKA) on bladder and colorectal function were examined in minipigs. In anesthetized animals, subcutaneous (SC) administration of 30–100 μg/kg increased