Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lesley M. Berghuis"'
Autor:
Cody P. Diamond, Faezeh Borzooee, Justin J King, Mani Larijani, Mahdi Asgharpour, Heather Fifield, Atefeh Ghorbani, Lesley M. Berghuis, Junbum Im
Publikováno v:
ACS pharmacologytranslational science. 4(4)
Activation-induced cytidine deaminase (AID) initiates antibody diversification by mutating immunoglobulin loci in B lymphocytes. AID and related APOBEC3 (A3) enzymes also induce genome-wide mutations and lesions implicated in tumorigenesis and tumor
Autor:
Heather Fifield, Sarah A. Branton, Lesley M. Berghuis, Mani Larijani, Brittany N. Bolt, Atefeh Ghorbani
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(7)
Activation-induced cytidine deaminase (AID) mutates immunoglobulin genes and acts genome-wide. AID targets robustly transcribed genes, and purified AID acts on single-stranded (ss) but not double-stranded (ds) DNA oligonucleotides. Thus, it is believ
Autor:
Justin J. King, Lesley M. Berghuis, Mani Larijani, Hala Abdouni, Atefeh Ghorbani, Heather Fifield
Publikováno v:
Molecular Immunology. 93:94-106
Activation-induced cytidine deaminase (AID) converts cytidine to uridine at Immunoglobulin (Ig) loci, initiating somatic hypermutation and class switching of antibodies. In vitro, AID acts on single stranded DNA (ssDNA), but neither double-stranded D
Autor:
Erynn A. Button, Heather Fifield, Junbum Im, Lesley M. Berghuis, Justin J. King, Mani Larijani, Hala Abdouni, Cody P. Diamond, Faeze Borzooee, Lisa Bacque, David N.G. Huebert, Erin McCarthy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:129415
Background AID/APOBEC3 (A3) enzymes instigate genomic mutations that are involved in immunity and cancer. Although they can deaminate any deoxycytidine (dC) to deoxyuridine (dU), each family member has a signature preference determined by nucleotides
Autor:
L. Aravind, Inês Trancoso, Elena N. Temereva, Mani Larijani, Michael Schorpp, Stephen J. Holland, Lakshminarayan M. Iyer, Heather Fifield, Prashant Shingate, Norimasa Iwanami, Fumiaki Sugahara, Guillaume Evanno, Sarah Peter, Lesley M. Berghuis, Justin J. King, Byrappa Venkatesh, Thomas Boehm, Shigeru Kuratani, Christine Strohmeier, Katarzyna Sikora, Emma M Quinlan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (14), pp.E3211-E3220. ⟨10.1073/pnas.1720871115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (14), pp.E3211-E3220. ⟨10.1073/pnas.1720871115⟩
Significance Cytidine deaminases of the AID/APOBEC family mutate the genetic material of pathogens or contribute to the generation and diversification of antibody repertoires in jawed vertebrates. In the extant jawless vertebrate, the lamprey, two me