Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Lesley M. Foley"'
Autor:
Lauren Taylor Rosenblum, ReidAnn E. Sever, Ryan Gilbert, David Guerrero, Sarah R. Vincze, Dominic M. Menendez, Peggy A. Birikorang, Mikayla R. Rodgers, Ambika Parmar Jaswal, Alexander C. Vanover, Joseph D. Latoche, Angel G. Cortez, Kathryn E. Day, Lesley M. Foley, Chaim T. Sneiderman, Itay Raphael, T. Kevin Hitchens, Jessie R. Nedrow, Gary Kohanbash, W. Barry Edwards, Marcus M. Malek
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Surgical resection is integral for the treatment of neuroblastoma, the most common extracranial solid malignancy in children. Safely locating and resecting primary tumor and remote deposits of disease remains a significant challen
Externí odkaz:
https://doaj.org/article/46a524a2699743eba0f0f099fc8cbf76
Autor:
Sarah R. Vincze, Ambika P. Jaswal, Stephen C. Frederico, Michal Nisnboym, Bo Li, Zujian Xiong, ReidAnn E. Sever, Chaim T. Sneiderman, Mikayla Rodgers, Kathryn E. Day, Joseph D. Latoche, Lesley M. Foley, T. Kevin Hitchens, Robin Frederick, Ravi B. Patel, Costas G. Hadjipanayis, Itay Raphael, Jessie R. Nedrow, W. Barry Edwards, Gary Kohanbash
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are few effective treatment options for GBM beyond surgery and chemo-radiation, and even with these interventions, median patient survival remains poor. Wh
Externí odkaz:
https://doaj.org/article/fc294d0e99e04fd0a3d770a3246088f3
Autor:
Michel Modo, Katherine Sparling, Jacob Novotny, Nikhita Perry, Lesley M. Foley, T. Kevin Hitchens
Publikováno v:
NeuroImage, Vol 282, Iss , Pp 120406- (2023)
The connectivity of the hippocampus is essential to its functions. To gain a whole system view of intrahippocampal connectivity, ex vivo mesoscale (100 μm isotropic resolution) multi-shell diffusion MRI (11.7T) and tractography were performed on ent
Externí odkaz:
https://doaj.org/article/47195800dec848e5b86e4046ef637a04
Autor:
Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S. Paruchuri, John P. Bielanin, Shamseldin Metwally, Helena C. M. Oft, Sydney G. Fischer, Victoria M. Fiesler, Tanusree Sen, Rajaneesh K. Gupta, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Franca Cambi, Nilkantha Sen, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic brain injury (TBI) and its impac
Externí odkaz:
https://doaj.org/article/9a5a38ebd5124d2ba4abf05f52c62bee
Autor:
Chunling Yuan, Ligen Shi, Zeyu Sun, Fei Xu, Chujun Wang, Jiajing Shan, T. Kevin Hitchens, Lesley M. Foley, Qing Ye, Jun Chen, Dandan Sun, Xiaoming Hu
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106063- (2023)
Recent research highlights the function of regulatory T cells (Tregs) in white matter integrity in CNS diseases. Approaches that expand the number of Tregs have been utilized to improve stroke recovery. However, it remains unclear if Treg augmentatio
Externí odkaz:
https://doaj.org/article/922a68ebcaf044a1a06d40a16b2bac7b
Autor:
Tetsuichi Saito, T. Kevin Hitchens, Lesley M. Foley, Nishant Singh, Shinsuke Mizoguchi, Masahiro Kurobe, Daisuke Gotoh, Teruyuki Ogawa, Tomonori Minagawa, Osamu Ishizuka, Christopher Chermansky, Jonathan Kaufman, Naoki Yoshimura, Pradeep Tyagi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract To quantify the urinary bladder wall T1 relaxation time (T1) before and after the instillation contrast mixture in rats previously subjected to water avoidance stress (WAS) and/or acute exposure to protamine sulfate (PS). Female Wistar rats
Externí odkaz:
https://doaj.org/article/4760258bb244492d84bb423083d095b7
Autor:
Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-21 (2021)
Abstract Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na+/H+ exchanger-1
Externí odkaz:
https://doaj.org/article/0b7b9c35d6e04796b892cecb0d5468ea
Autor:
Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Jingfang Zhang, Huachen Huang, Md Nabiul Hasan, Anna E. Skrzypiec, Mariusz Mucha, Daniel Duran, Wei Huang, Robert Pawlak, Lesley M. Foley, T. Kevin Hitchens, Margaret B. Minnigh, Samuel M. Poloyac, Seth L. Alper, Bradley J. Molyneaux, Andrew J. Trevelyan, Kristopher T. Kahle, Dandan Sun, Xianming Deng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.
Externí odkaz:
https://doaj.org/article/3b3910c818a141759af3688133b30605
Autor:
Alexandra Foster, Shubhanchi Nigam, David S Tatum, Itay Raphael, Jide Xu, Rajeev Kumar, Elizabeth Plakseychuk, Joseph D Latoche, Sarah Vincze, Bo Li, Rajan Giri, Lauren H McCarl, Robert Edinger, Murat Ak, Vishal Peddagangireddy, Lesley M Foley, T Kevin Hitchens, Rivka R Colen, Ian F Pollack, Ashok Panigrahy, Darren Magda, Carolyn J Anderson, W Barry Edwards, Gary Kohanbash
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103571- (2021)
Background: Malignant gliomas are deadly tumours with few therapeutic options. Although immunotherapy may be a promising therapeutic strategy for treating gliomas, a significant barrier is the CD11b+ tumour-associated myeloid cells (TAMCs), a heterog
Externí odkaz:
https://doaj.org/article/262ba25f595340aea3143132472fdff3
Autor:
Qingxiu Zhang, Wen Zhu, Fei Xu, Xuejiao Dai, Ligen Shi, Wei Cai, Hongfeng Mu, T Kevin Hitchens, Lesley M Foley, Xiangrong Liu, Fang Yu, Jie Chen, Yejie Shi, Rehana K Leak, Yanqin Gao, Jun Chen, Xiaoming Hu
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000330 (2019)
The repair of white matter damage is of paramount importance for functional recovery after brain injuries. Here, we report that interleukin-4 (IL-4) promotes oligodendrocyte regeneration and remyelination. IL-4 receptor expression was detected in a v
Externí odkaz:
https://doaj.org/article/09face6dbc2d4aa0bafa12cacafd945a