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of 6
pro vyhledávání: '"Lesley M Chiverton"'
Autor:
Emma J Mead, Lesley M Chiverton, Sarah K Spurgeon, Elaine B Martin, Gary A Montague, C Mark Smales, Tobias von der Haar
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47422 (2012)
Monoclonal antibodies are commercially important, high value biotherapeutic drugs used in the treatment of a variety of diseases. These complex molecules consist of two heavy chain and two light chain polypeptides covalently linked by disulphide bond
Externí odkaz:
https://doaj.org/article/f48ec04bba7c4a4094a9be43645a0f0b
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1603
Host cell protein content during bioprocessing of biotherapeutic proteins generated from cultured Chinese hamster ovary (CHO) cells is typically measured using immunological and gel-based methods. Estimation of HCP concentration is usually undertaken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f282c2808263c38877e4033027c3fef9
https://pubmed.ncbi.nlm.nih.gov/28493135
https://pubmed.ncbi.nlm.nih.gov/28493135
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969715
Host cell protein content during bioprocessing of biotherapeutic proteins generated from cultured Chinese hamster ovary (CHO) cells is typically measured using immunological and gel-based methods. Estimation of HCP concentration is usually undertaken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12bad8abf0a862bf57829de2baeeb9c5
https://doi.org/10.1007/978-1-4939-6972-2_16
https://doi.org/10.1007/978-1-4939-6972-2_16
Autor:
Lesley M. Chiverton
Publikováno v:
Immunotherapy. 3:13-16
The Miniaturisation – Micro Scale Bioprocess Development conference organized by Euroscicon hosted 44 delegates from the UK, Germany and Switzerland. The aim of the meeting was to highlight the recent technologies used in high-throughput bioprocess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eadced74d143b0c7bc880b13cc171165
https://doi.org/10.2217/imt.10.97
https://doi.org/10.2217/imt.10.97
Autor:
Christopher Mark Smales, Phillip C. Wright, Byron J. Rees, Peter R. Levison, Caroline A. Evans, Jagroop Pandhal, Andrew Landels, Lesley M. Chiverton
Publikováno v:
Biotechnology Journal
There are few studies defining CHO host cell proteins (HCPs) and the flux of these throughout a downstream purification process. Here we have applied quantitative iTRAQ proteomics to follow the HCP profile of an antibody (mAb) producing CHO‐S cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5ad8888cc21ad7f011d0cbdc488817
https://pubmed.ncbi.nlm.nih.gov/27214759
https://pubmed.ncbi.nlm.nih.gov/27214759
Autor:
Lesley M. Chiverton
Publikováno v:
Expert review of proteomics. 7(5)
The Modern Challenges in Therapeutic Protein Production conference hosted 44 delegates from the UK and Germany and was organized by EuroSciCon. The aim of the meeting was to look at the challenges that currently face the production of therapeutic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8bdc15536c55d980b25b48df1cdbef
https://pubmed.ncbi.nlm.nih.gov/20973635
https://pubmed.ncbi.nlm.nih.gov/20973635