Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lesley Leong"'
Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.
Autor:
Eun-Gyung Lee, Jessica Tulloch, Sunny Chen, Lesley Leong, Aleen D Saxton, Brian Kraemer, Martin Darvas, C Dirk Keene, Andrew Shutes-David, Kaitlin Todd, Steve Millard, Chang-En Yu
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227667 (2020)
The apolipoprotein E gene (APOE) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet the expression of APOE is not clearly understood. For example, it is unclear whether AD patients have elevated or decreased APOE expres
Externí odkaz:
https://doaj.org/article/97380ad8d94c4209b91bc28c33be538e
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10440
The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its association with Alzheimer’s disease (AD) and longevity. This genetic association appears across multiple genes in the APOE locus. Despite the apparent diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d4155f7c8c2dda9ca88e53929ab1b706
The APOE locus has garnered significant clinical interest because of its association with Alzheimer's disease (AD) and longevity. This genetic association appears across multiple genes in the APOE locus. Despite the apparent differences between AD an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f8f536e4bcc88e13a30aefc214fd12
https://doi.org/10.20944/preprints202304.1128.v1
https://doi.org/10.20944/preprints202304.1128.v1
Autor:
C. Dirk Keene, Eun Gyung Lee, Chang En Yu, Lesley Leong, Steven P. Millard, Sunny Chen, Jessica Tulloch, Zachary Thomson
Publikováno v:
Brain Research. 1698:179-186
The apolipoprotein E gene (APOE) is the strongest genetic risk factor for developing Alzheimer's disease (AD). Our recent identification of altered APOE DNA methylation in AD postmortem brain (PMB) prompted this follow-up study. Our goals were to (i)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eff6c03f67fec222b6e43bbea63de23
https://doi.org/10.1016/j.brainres.2018.08.006
https://doi.org/10.1016/j.brainres.2018.08.006
Autor:
Eliezer Masliah, Peter T. Nelson, Julia Kofler, Randy Woltjer, Jeffrey Kaye, Lesley Leong, Douglas Galasko, James B. Leverenz, Chang En Yu, Oscar L. Lopez, Sunny Chen, Gregory A. Jicha, Jessica Tulloch, C. Dirk Keene, Janna H. Neltner, Andrew Shutes-David, Steven P. Millard, Debby W. Tsuang
Publikováno v:
Alzheimer's & Dementia. 14:889-894
Introduction Inheritance of the e4 allele of apolipoprotein E ( APOE ) increases a person's risk of developing both Alzheimer's disease (AD) and Lewy body dementia (LBD), yet the underlying mechanisms behind this risk are incompletely understood. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58a3459b92b357e1bb6ed8c99cde38b
https://doi.org/10.1016/j.jalz.2018.02.005
https://doi.org/10.1016/j.jalz.2018.02.005
Publikováno v:
Genes
Volume 12
Issue 6
Genes, Vol 12, Iss 871, p 871 (2021)
Volume 12
Issue 6
Genes, Vol 12, Iss 871, p 871 (2021)
Increasing evidence suggests that the Translocase of Outer Mitochondria Membrane 40 (TOMM40) gene may contribute to the risk of Alzheimer’s disease (AD). Currently, there is no consensus as to whether TOMM40 expression is up- or down-regulated in A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9ab2421b426cde48ccf85805323eea
https://doi.org/10.3390/genes12060871
https://doi.org/10.3390/genes12060871
Autor:
Jessica Tulloch, Steve Millard, Lesley Leong, Sunny Chen, Kaitlin Todd, Eun-Gyung Lee, Chang En Yu
Publikováno v:
Alzheimer's & Dementia. 15:P1308-P1309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45b9c5bea620990cbb1a754cfa0b8da
https://doi.org/10.1016/j.jalz.2019.06.3749
https://doi.org/10.1016/j.jalz.2019.06.3749
Autor:
Lesley Leong, Steve Millard, Kaitlin Todd, Jessica Tulloch, Andrew Shutes-David, Martin Darvas, Brian C. Kraemer, Aleen D. Saxton, Eun Gyung Lee, Chang En Yu, C. Dirk Keene, Sunny Chen
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227667 (2020)
PLoS ONE
PLoS ONE
The apolipoprotein E gene (APOE) is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the expression of APOE is not clearly understood. For example, it is unclear whether AD patients have elevated or decreased APOE expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7d80a0d7279791909386bb2ba4568b
https://doi.org/10.1371/journal.pone.0227667
https://doi.org/10.1371/journal.pone.0227667
Autor:
Chang En Yu, C. Dirk Keene, Patrick A. Navas, Brian C. Kraemer, James Anthony Gill, Eiron Cudaback, Franziska Lutz, Jessica Foraker, Lynn M. Bekris, Lesley Leong, Zachary Thomson, Thomas J. Montine, Aleen D. Saxton
Publikováno v:
Human Molecular Genetics. 22:5036-5047
The human apolipoprotein E (APOE) gene plays an important role in lipid metabolism. It has three common genetic variants, alleles ɛ2/ɛ3/ɛ4, which translate into three protein isoforms of apoE2, E3 and E4. These isoforms can differentially influenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdecb79c795eda66caf720194d464378
https://doi.org/10.1093/hmg/ddt354
https://doi.org/10.1093/hmg/ddt354
Autor:
Dorcas J. Dobie, Sulgi Kim, Ellen M. Wijsman, Lesley Leong, Allen D. Radant, Steven P. Millard, Chang En Yu, Debby W. Tsuang
Publikováno v:
Genetic Epidemiology. 36:488-498
Copy Number Variation (CNV) is increasingly implicated in disease pathogenesis. CNVs are often identified by statistical models applied to data from single nucleotide polymorphism (SNP) panels. Family information for samples provides additional infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade4c2beabfe6082944ec77c36b08f0b
https://doi.org/10.1002/gepi.21643
https://doi.org/10.1002/gepi.21643