Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lesley K. MacLachlan"'
Publikováno v:
Molecular Microbiology. 49:1191-1200
Summary Two-component signal transduction (TCST) pathways are regulatory systems that are highly homologous throughout the bacterial kingdom . Their established role in virulence and absence in vertebrates has made TCST an attractive target for thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6331f4ed492acbbe7a34dff6dc05d8d1
https://doi.org/10.1046/j.1365-2958.2003.03628.x
https://doi.org/10.1046/j.1365-2958.2003.03628.x
Autor:
Paul S. Carter, Stuart C. Findlow, Ceri J. Lewis, Jo J. Jones, Julia A. Hubbard, Lesley K. MacLachlan, Peter R. Johnson, Andrew P. Fosberry, Joanne C. Ladds
Publikováno v:
Analytical Biochemistry. 299:31-36
Bacterial response regulators are attractive targets for antibacterial drug development, yet random screening against these targets has failed as yet to identify chemicals that constitute viable leads. Alternative methods to provide leads for drug de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22932247f8554d2eb68c3fc15fe44a8a
https://doi.org/10.1006/abio.2001.5365
https://doi.org/10.1006/abio.2001.5365
Autor:
Stephen A. Salisbury, Anthony G. Lee, Colin J. Salter, Lesley K. MacLachlan, S.D. Jane, E. John Tremeer, Martin J. Saunders, David G. Reid
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1106:264-272
The N- and C-terminally protected peptide N -acetyl-Asp-Phe-Ala-Asn-Arg-Val-Leu-Leu-Ser-Leu-Phe-Thr-Ile-Glu-Met-Leu-Leu-Lys-Met-Tyr-Gly-Leu-NH 2 , closely based on the sequence of the putative S2 membrane spanning helix of domain II of the dihydropyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9513ce01dca1532d45711268419e8450
https://doi.org/10.1016/0005-2736(92)90005-7
https://doi.org/10.1016/0005-2736(92)90005-7
Autor:
David G. Reid, Andrew Gee, Keith E. Suckling, Colin J. Suckling, Lesley K. MacLachlan, Susan R. Cresswell
Publikováno v:
Chemistry and Physics of Lipids. 58:175-181
Fluorine-19 nuclear magnetic resonance at 235 MHz has been used to characterize the NMR properties of two novel fluorinated sterols, 6,6-difluorocholestanol and 7,7-difluorocholestanol, and various 3-ester derivatives. 19F-19F and 19F-1H coupling con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b941d212d35fd7f4bc45f40e67a9037
https://doi.org/10.1016/0009-3084(91)90123-s
https://doi.org/10.1016/0009-3084(91)90123-s
Autor:
Michael J. Raw, David G. Reid, Lesley K. MacLachlan, Paul A. Smith, Robert C. Mitchell, Michael J. Graham
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1029:24-32
Three complementary techniques, differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy, have been used to characterise the interactions between dimyristoylphosphatidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df81b0f1fb3c6a82b21da515adec813
https://doi.org/10.1016/0005-2736(90)90432-n
https://doi.org/10.1016/0005-2736(90)90432-n
Publikováno v:
Journal of Biological Chemistry. 265:9744-9753
1H NMR spectroscopy at 360 MHz has been used to study the interactions between the calmodulin function inhibitor calmidazolium (R24571) and (i) calmodulin (CaM) and (ii) skeletal muscle troponin C (sTnC). One equivalent of racemic calmidazolium binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3983b43f8b8883efa0538ffbbc4c077
https://doi.org/10.1016/s0021-9258(19)38734-4
https://doi.org/10.1016/s0021-9258(19)38734-4
Publikováno v:
Journal of Biological Chemistry. 265:9764-9770
Stopped-flow fluorescence kinetic measurements, circular dichroism (CD), and 1H nuclear magnetic resonance (NMR) spectroscopy at 360 MHz have been used to study the interaction of the calcium-channel blocker and calmodulin antagonist bepridil with ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e88cb8f8d7c6267eccf313959be41be6
https://doi.org/10.1016/s0021-9258(19)38736-8
https://doi.org/10.1016/s0021-9258(19)38736-8
Publikováno v:
Journal of Biological Chemistry. 265:9754-9763
Proton (1H) NMR at 360 MHz has been used to characterize calcium-induced spectral changes in bovine cardiac troponin C in more detail than hitherto reported (Hincke, M. T., Sykes, B. D., and Kay, C. M. (1981) Biochemistry 20, 3286-3294). The observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93610ba3de3e5e3a8bcb8041880594df
https://doi.org/10.1016/s0021-9258(19)38735-6
https://doi.org/10.1016/s0021-9258(19)38735-6
Autor:
Patrick Camilleri, Christopher J. Thorpe, David G. Reid, Catherine A. Dyke, Simon P. Robinson, Lesley K. MacLachlan
Publikováno v:
Chirality. 2:229-232
1H nuclear magnetic resonance at 360 MHz shows that SK&F 96365 (1-(beta-[3-(p-methoxyphenyl)-propyloxy]-p-methoxyphenethyl)-1H- imidazole hydrochloride), an antagonist of mammalian receptor-operated calcium channels, interacts with the calcium-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0654205c248b664a0a6fa632b8905c1
https://doi.org/10.1002/chir.530020407
https://doi.org/10.1002/chir.530020407
