Výsledky vyhledávání - "Lesley J. Hinks"

The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study

Autor: Tom R. Gaunt, Nicholas J. Timpson, Debbie A Lawlor, Lesley J. Hinks, Ian N.M. Day, George Davey Smith, Shah Ebrahim

Publikováno v: Paediatric and Perinatal Epidemiology. 20:244-250

It has been hypothesised that paraoxonase genes would be related to adverse pregnancy outcomes, via a maternal or fetal effect on placental hypoperfusion and thrombosis. To date only two studies have assessed this possibility. In this study we assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c3d970880f6c5d8aace0c2181dc842
https://doi.org/10.1111/j.1365-3016.2006.00716.x

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CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents

Autor: Derek G Cook, Shuwen Huang, Julie A Gilg, Xiao-he Chen, Peter H. Whincup, Martin J. Jarvis, Ian N.M. Day, Shu Ye, Lesley J. Hinks

Publikováno v: Pharmacogenetics and Genomics. 15:839-850

Objectives: Smoking is a major cause of death and often initiates in adolescence. Mutations in CYP2A6 slow metabolism of nicotine to cotinine. Haploinsufficiency in adults is associated with lower cigarette consumption, lower cotinine level and highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cae1b16f723544aeb77e0ef16ef95c1
https://doi.org/10.1097/01213011-200512000-00002

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The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study

Autor: Nicholas J. Timpson, George Davey Smith, Debbie A Lawlor, Shah Ebrahim, Lesley J. Hinks, Tom R. Gaunt, Ian N.M. Day

Publikováno v: Journal of Epidemiology & Community Health. 61:85-87

Background: The association between the R allele of PON1 Q192R and symptoms reported by sheep dippers and Gulf War veterans has been used to suggest a biological basis for these symptoms. In the absence of such studies in non-occupational populations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1709c67a64ab3a23426f1e4a3cf875
https://doi.org/10.1136/jech.2006.049247

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Determinants of the rate of nicotine metabolism and effects on smoking behavior

Autor: Robyn Jacob, Ian N.M. Day, Elaine C. Johnstone, Robert Walton, Michael Murphy, Neal L. Benowitz, Lesley J. Hinks, Anna Cargill

Publikováno v: Clinical pharmacology and therapeutics. 80(4)

Studies on cytochrome P450 (CYP) 2A6 suggest that genotype affects the rate of nicotine metabolism and, consequently, cigarette consumption. However, known alleles of CYP2A6 associated with fast or slow metabolism are relatively uncommon, and there r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d73265d27c6cfb631b3fa242ea28c8
https://pubmed.ncbi.nlm.nih.gov/17015050

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The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

Autor: Debbie A, Lawlor, Ian N M, Day, Tom R, Gaunt, Lesley J, Hinks, Patricia J, Briggs, Matthew, Kiessling, Nick, Timpson, George Davey, Smith, Shah, Ebrahim

Publikováno v: BMC Genetics, Vol 5, Iss 1, p 17 (2004)
BMC Genetics

Background There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included predominantly men and the association in women is unclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d6db9bdf0ff5d83c3823fb90c2060c2a
http://www.biomedcentral.com/1471-2156/5/17

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Manual 768 or 384 well microplate gel ‘dry’ electrophoresis for PCR checking and SNP genotyping

Autor: Hamid Rassoulian, Ian N.M. Day, Lesley J. Hinks, Tom R. Gaunt

Electrophoresis continues to be a mainstay in molecular genetic laboratories for checking, sizing and separating both PCR products, nucleic acids derived from in vivo or in vitro sources and nucleic acid–protein complexes. Many genomic and genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60018cc10db71b6b01b3f9a82225139
https://europepmc.org/articles/PMC154236/

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A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort

Autor: B. Zhang, S.R. Hammans, Sarah Adio, D. Groot, Shu Ye, Ian N. M. Day, Avan Aihie Sayer, P.J. Smythe, Lesley J. Hinks, Cyrus Cooper

Publikováno v: Biochemical Society transactions. 31(2)

Somatic mutation in the mitochondrial genome occurs much more rapidly than in the nuclear genome and is a feature, possibly contributory, of the aging of cells and tissues. Identifying mitochondrial sequence changes in blood DNA of elderly subjects m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10a16cf58263c3b71e620de025877f3
https://pubmed.ncbi.nlm.nih.gov/12653657

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Microplate Array Diagonal Gel Electrophoresis (MADGE) Methodologies: The First Five Years

Autor: Sandra D. O'Dell, A Voropanov, Emmanuel Spanakis, Lesley J. Hinks, Xaio-He Chen, Ian N. M. Day

Publikováno v: Molecular Genetic Epidemiology — A Laboratory Perspective ISBN: 9783540413875

Recently, the Wellcome Trust (UK) and a consortium of major pharmaceutical companies have announced a 2-year initiative costing £28 million to identify 300, 000 and map 150, 000 human single nucleotide polymorphisms, information which will be availa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1560683b0345b29ef354da469abba584
https://doi.org/10.1007/978-3-642-56207-5_7

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