Výsledky vyhledávání - "Lesley J. Hickman"

Regulation of the cycling oftimeless (tim) RNA

Autor: Amita Sehgal, Garrick K. Wang, Thomas K. Darlington, Dechun Chen, Andrea Ousley, Yifeng Chen, Steve A. Kay, Lesley J. Hickman, Weili Fu

Publikováno v: Journal of Neurobiology. 47:161-175

Circadian rhythms in Drosophila depend upon expression of the timeless (tim) and period (per) genes, which encode interacting components of the endogenous clock. These two clock genes show a robust circadian oscillation in transcription rate as well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5f12f13157c3b98423e4847d351b2e
https://doi.org/10.1002/neu.1024

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γ-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid β Peptides of Varying Length

Autor: Rong Wang, Sacha N. Uljon, Michael P. Murphy, Lesley J. Hickman, Todd E. Golde, Christopher B. Eckman

Publikováno v: Journal of Biological Chemistry. 274:11914-11923

gamma-Secretase activity is the final cleavage event that releases the amyloid beta peptide (Abeta) from the beta-secretase cleaved carboxyl-terminal fragment of the amyloid beta protein precursor (APP). No protease responsible for this highly unusua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085f6d5ca3a7b14f8cfeb770547765cd
https://doi.org/10.1074/jbc.274.17.11914

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Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin

Autor: Wayne A. Dornan, Alex R. McCampbell, Gregory P. Tinkler, Lesley J. Hickman, Anthony W. Bannon, Michael W. Decker, Karen L. Gunther

Publikováno v: Behavioural Brain Research. 82:93-101

In this study, we investigated the effects of 192 IgG saporin injections into the medial septal area (MSA), or nucleus basalis magnocellularis (NBM), and combined injections into the MSA and NBM, on water maze and radial arm maze performance in the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0370f70ec6bfb7580440e85dfbed771
https://doi.org/10.1016/s0166-4328(97)81112-6

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Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies

Autor: Mark M. Emerson, Andrea Ousley, Khaja Zafarullah, Amita Sehgal, Lesley J. Hickman, Yifeng Chen

Circadian (~24-hr) rhythms in Drosophila melanogaster depend upon cyclic expression of the period (per) and timeless (tim) genes, which encode interacting components of the endogenous clock. The per gene has been isolated from other insects and, more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4276caa282d6cbdbb630a851baeae24
https://europepmc.org/articles/PMC1459808/

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