Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lesley J. Gaydos"'
Autor:
Richard L. Theriault, Allan Lipton, V. Chinchili, Gabriel N. Hortobagyi, John J. Seaman, Robert Knight, Lesley J. Gaydos, D. Clemens, Laurence M. Demers, E. Curley, D. Reitsma
Publikováno v:
European Journal of Cancer. 34:2021-2026
Pyridinoline (PYD), deoxypyridinoline (DPD), and N-telopeptide (NTX) are markers of bone resorption. In cancer patients with bone metastases, NTX is more often elevated than either of the pyridinolines. Bisphosphonates inhibit osteoclasts and their t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85f01c220fafc4abde99323a026e527
https://doi.org/10.1016/s0959-8049(98)00277-9
https://doi.org/10.1016/s0959-8049(98)00277-9
Autor:
Xianglin Shi, Yongju Lu, Douglas C. Kuhn, Lesley J. Gaydos, Fei Chen, Laurence M. Demers, Shao Cong Sun
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 272:L779-L786
The role of nuclear factor (NF)-kappaB transcription factor in silica-induced cyclooxygenase (COX) II gene expression was examined in the rat alveolar macrophage cell line NR8383. Our results indicate that NF-kappaB can be activated in this cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634e6778d85e70b9534173ee9562a7f5
https://doi.org/10.1152/ajplung.1997.272.4.l779
https://doi.org/10.1152/ajplung.1997.272.4.l779
Autor:
Yongju Lu, Laurence M. Demers, Shao Cong Sun, Xianglin Shi, Lesley J. Gaydos, Fei Chen, Douglas C. Kuhn
Publikováno v:
Biochemical and Biophysical Research Communications. 231:99-102
Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from a natural Chinese herbal medicine. While this alkaloid has been shown to exhibit antifibrotic and anti-inflammatory activities, its mechanism of action is unknown. The present study was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003b27ac7f5d0b1d417f472faaecef29
https://doi.org/10.1006/bbrc.1997.6057
https://doi.org/10.1006/bbrc.1997.6057
Autor:
James R. Connor, B. S. Snyder, Lesley J. Gaydos, John L. Stauffer, Douglas C. Kuhn, Laurence M. Demers
Publikováno v:
Applied Occupational and Environmental Hygiene. 11:969-972
The disposition of iron in the alveolar macrophage (AM) may be a critical factor in its reactivity to inhaled mineral dust. Dust particles such as coal and silica contain leachable iron or iron oxides on their surface which may become available as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8b19ae9901d6daea7c1ce2ddb393e7f
https://doi.org/10.1080/1047322x.1996.10389998
https://doi.org/10.1080/1047322x.1996.10389998
Publikováno v:
Applied Occupational and Environmental Hygiene. 11:909-913
It has been suggested that prior exposure to mineral dust may attenuate the ability of the alveolar macrophage (AM) to respond to subsequent provocative stimuli, thus compromising the host defense mechanism. On the contrary, prior exposure of the AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b48aac3b2dccc549e8e39e91f517e3
https://doi.org/10.1080/1047322x.1996.10389988
https://doi.org/10.1080/1047322x.1996.10389988
Essential Role of NF-κB Activation in Silica-Induced Inflammatory Mediator Production in Macrophages
Publikováno v:
Biochemical and Biophysical Research Communications. 214:985-992
In this report, we demonstrate that NF-kappa B, a ubiquitous transcription factor, plays an essential role in silica-induced inflammatory mediator production in the mouse macrophage cell line RAW 264.7. Compared to the effect of lipopolysaccharide (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168f95f98a8f1ca33dc3784cba9a3ed4
https://doi.org/10.1006/bbrc.1995.2383
https://doi.org/10.1006/bbrc.1995.2383
Publikováno v:
Journal of Toxicology and Environmental Health. 46:9-21
Eicosanoids and cytokines produced by alveolar macrophages (AM) are key mediators of pulmonary inflammation and fibrosis. In order to determine if eicosanoid production and cytokine production are altered in AM obtained from coal miners, we compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882131aaffba6f70cdc4148bc3948c6d
https://doi.org/10.1080/15287399509532014
https://doi.org/10.1080/15287399509532014
Publikováno v:
Prostaglandins. 46:195-205
Tumor necrosis factor alpha (TNF alpha) and thromboxane A2 (TXA2) are major products of the activated alveolar macrophage and serve as key mediators of lung injury. In order to determine if the synthesis of TXA2 and the release of TNF alpha are assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0f038294b36440e633d158a8fd4ae6
https://doi.org/10.1016/0090-6980(93)90003-p
https://doi.org/10.1016/0090-6980(93)90003-p
Publikováno v:
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 104(3)
Nitric oxide (NO), a nitrogen-free radical, plays an important role in mediating inflammatory reaction and cytotoxicity of tissue. To determine whether NO was involved in silica-induced pulmonary tissue damage, we studied the effects of silica on nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319fc4990cd071a89557f722d2142c76
https://pubmed.ncbi.nlm.nih.gov/8611191
https://pubmed.ncbi.nlm.nih.gov/8611191
Publikováno v:
Biochemical and biophysical research communications. 214(3)
In this report the differential regulation of NF-kappa B and nitric oxide (NO) was investigated in the mouse macrophage cell line RAW 264.7 following exposure to a mineral dust (silica) and/or an endotoxin (Lipopolysaccharide, LPS). The results indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adad607ddb2087d07949d87a40f4930a
https://pubmed.ncbi.nlm.nih.gov/7575553
https://pubmed.ncbi.nlm.nih.gov/7575553