Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lesley Griner"'
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Figure 4. Growth of individual tumors shown in Fig. 7A-C are given for HCT 116 (A), MIA PaCa-2 (B) and MEL-JUSO (C) cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2175679541bcf9cea1bfe131eae3dc26
https://doi.org/10.1158/1078-0432.22480680
https://doi.org/10.1158/1078-0432.22480680
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
p-ERK MSD results in RAS mutant cells ectopically expressed ARAF variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a06d1625834f006100db5b3daf5cfda
https://doi.org/10.1158/1078-0432.22480659
https://doi.org/10.1158/1078-0432.22480659
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Purpose:Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein, we describe in detail novel properties of the type II RAF inhibitor, LXH254.Experimental Design:LXH254 was profiled in biochemical, in vitro, and in vivo assays,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d1b1fef6c36ab7ea76ff43f5c11d34
https://doi.org/10.1158/1078-0432.c.6530499.v1
https://doi.org/10.1158/1078-0432.c.6530499.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703cf919309a8d21ff2ef43d79a39ca5
https://doi.org/10.1158/1078-0432.22480674.v1
https://doi.org/10.1158/1078-0432.22480674.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Proliferation IC50 values for various cell lines and cell line derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824b1c25a99242cc82aa0652e3f095e1
https://doi.org/10.1158/1078-0432.22480662.v1
https://doi.org/10.1158/1078-0432.22480662.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Growth inhibition IC50 values (nM) of several RAF inhibitors in a panel of cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27325eb515eee0f4175cfd54868d5839
https://doi.org/10.1158/1078-0432.22480650.v1
https://doi.org/10.1158/1078-0432.22480650.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Results of Kinativ studies using LXH254 in HCT 116 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04067400795ea10f20b7a3cc672ed17e
https://doi.org/10.1158/1078-0432.22480668.v1
https://doi.org/10.1158/1078-0432.22480668.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Figure 2. Western blot analysis of CRISPR-CAS9 cell lines and exogenously expressed ARAF variants used in experiments shown in Figures 3-7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e88161dfeaa94370f0c1348e6dd0941
https://doi.org/10.1158/1078-0432.22480686.v1
https://doi.org/10.1158/1078-0432.22480686.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Figure 3. (A) Shown are western blots using antibodies directed against T202/Y204 phosphorylated ERK1/2 following incubation with a range of concentrations of LXH254 over a 4 - 72 hour period. Which individual RAF protein is not express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2281e5c8b0fa1fcbbebf99efb569824f
https://doi.org/10.1158/1078-0432.22480683
https://doi.org/10.1158/1078-0432.22480683
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Biochemical activity of LXH254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc418b11fe5a9a4f4b144cdfd021f760
https://doi.org/10.1158/1078-0432.22480671
https://doi.org/10.1158/1078-0432.22480671