Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lesley F. Haire"'
Autor:
Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for it
Externí odkaz:
https://doaj.org/article/7ab848514085441b822b8a2f77f90739
Autor:
Simon Pennell, Anne-Cécile Déclais, Jiejin Li, Lesley F. Haire, Wioletta Berg, José W. Saldanha, Ian A. Taylor, John Rouse, David M.J. Lilley, Stephen J. Smerdon
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 84-93 (2014)
FAN1 is a structure-selective DNA repair nuclease with 5′ flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair nuclease (“VRR-Nuc”) “module”
Externí odkaz:
https://doaj.org/article/dfe1587476f24143bcaf75daa098ef8d
Autor:
Erhard van der Vries, Patrick J Collins, Sebastien G Vachieri, Xiaoli Xiong, Junfeng Liu, Philip A Walker, Lesley F Haire, Alan J Hay, Martin Schutten, Albert D M E Osterhaus, Steve R Martin, Charles A B Boucher, John J Skehel, Steve J Gamblin
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002914 (2012)
Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The
Externí odkaz:
https://doaj.org/article/b7d5f67f66c34811b64f6ffdbd9cd721
Autor:
Lesley F. Haire, Simon Pennell, Anne-Cécile Déclais, Wioletta Berg, John Rouse, David M.J. Lilley, Stephen J. Smerdon, Jiejin Li, Ian A. Taylor, José W. Saldanha
Publikováno v:
Cell Reports
Cell Reports, Vol 8, Iss 1, Pp 84-93 (2014)
Cell Reports, Vol 8, Iss 1, Pp 84-93 (2014)
Summary FAN1 is a structure-selective DNA repair nuclease with 5′ flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair nuclease (“VRR-Nuc”) “m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b31f044f9d759938a28c2593dcaeb6
Autor:
Patrick J. Collins, Lesley F. Haire, Michael S. Bennett, Philip A. Walker, John W. McCauley, Steven J. Gamblin, Rodney S. Daniels, John J. Skehel, Stephen R. Martin, Xiaoli Xiong, Stephen A. Wharton
Publikováno v:
Nature. 499:496-499
Of the 132 people known to have been infected with H7N9 influenza viruses in China, 37 died, and many were severely ill. Infection seems to have involved contact with infected poultry. We have examined the receptor-binding properties of this H7N9 vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3febe464e2d110c7bea171cd1da22a5
https://doi.org/10.1038/nature12372
https://doi.org/10.1038/nature12372
Publikováno v:
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
The expression, purification and crystallization of an N-terminal fragment of SHARPIN are reported. Diffraction-quality crystals were obtained using a two-dimensional grid-screen seeding technique.
An N-terminal fragment of human SHARPIN was rec
An N-terminal fragment of human SHARPIN was rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970c8126df9db07f941c3be043e0450a
http://europepmc.org/articles/PMC3388930
http://europepmc.org/articles/PMC3388930
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: SHARPIN is a subunit of the E3 ligase complex LUBAC and the gene that is mutated in chronic proliferative dermatitis mice. Results: The N-terminal portion of SHARPIN adopts the PH superfold and mediates homodimerization. Conclusion: The P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ef26226128e5a81567c9b77c08db13
https://doi.org/10.1074/jbc.m112.359547
https://doi.org/10.1074/jbc.m112.359547
Autor:
Roksana W. Ogrodowicz, Matthew J. Sanders, David Carling, Martin C. Schmidt, Fiona C. Leiper, Faith V. Mayer, Philip A. Walker, David Carmena, Bing Xiao, Chun Jing, Elizabeth Underwood, Steven J. Gamblin, Stephen R. Martin, Richard Heath, Rhonda R. McCartney, Lesley F. Haire
Publikováno v:
Cell Metabolism
Summary The SNF1 protein kinase complex plays an essential role in regulating gene expression in response to the level of extracellular glucose in budding yeast. SNF1 shares structural and functional similarities with mammalian AMP-activated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798ca074a8da5b6d0d49b2f0411c92be
Autor:
Gloria Agatic, Giosiana Codoni, Antonio Lanzavecchia, Andrea Minola, Steven J. Gamblin, Lesley F. Haire, Jarrod Voss, Debora Pinna, John J. Skehel, Isabella Giacchetto-Sasselli, Fabrizia Vanzetta, Nigel J. Temperton, Davide Corti, David Jarrossay, Patrick J. Collins, Sebastien G. Vachieri, Chiara Silacci, Siro Bianchi, Annalisa Macagno, Blanca Fernandez-Rodriguez, Johannes P. M. Langedijk, Federica Sallusto, Lesley J. Calder
Publikováno v:
Science
The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-sought goal for therapeutic approaches and vaccine design. Using a single-cell culture method for screening large numbers of human plasma cells, we isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781c44002c3643781c70fc2a18b9da18
https://doi.org/10.1126/science.1205669
https://doi.org/10.1126/science.1205669
Autor:
Faith V. Mayer, Stephen R. Martin, David Carmena, Matthew J. Sanders, Bing Xiao, Rein Aasland, David Carling, Chun-Xia Jing, Steven Howell, Richard Heath, Peter Saiu, Elizabeth Underwood, Lesley F. Haire, John F. Eccleston, Steven J. Gamblin, Philip A. Walker
Publikováno v:
Nature
The heterotrimeric AMP-activated protein kinase (AMPK) has a key role in regulating cellular energy metabolism; in response to a fall in intracellular ATP levels it activates energy-producing pathways and inhibits energy-consuming processes. AMPK has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e71bd24eac888f8a356411281a15de
http://europepmc.org/articles/PMC3078618
http://europepmc.org/articles/PMC3078618