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pro vyhledávání: '"Lesley Earl"'
We start from the water placement in cryo-EM maps and in X-ray crystal structures of beta-galactosidase. We apply MD simulations to analyze the behavior of the placed water, and how they are bound to the protein residues. We analyze the solvent expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6c80699435aa1103f47e1102c0c4da
https://doi.org/10.26434/chemrxiv.12449297.v1
https://doi.org/10.26434/chemrxiv.12449297.v1
We start from the water placement in cryo-EM maps and in X-ray crystal structures of beta-galactosidase. We apply MD simulations to analyze the behavior of the placed water, and how they are bound to the protein residues. We analyze the solvent expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65143aeaa1ad0139dee859bda6281d4a
https://doi.org/10.26434/chemrxiv.12449297
https://doi.org/10.26434/chemrxiv.12449297
Autor:
Ian Indans, Michael R. Woolhiser, Ian C. Dewhurst, Jon A. Hotchkiss, Lesley Earl, Robert Guest, Richard Billington, Sean C. Gehen, Stuart Creton
Publikováno v:
Critical Reviews in Toxicology. 40:50-83
Assessment of the acute systemic oral, dermal, and inhalation toxicities, skin and eye irritancy, and skin sensitisation potential of chemicals is required under regulatory schemes worldwide. In vivo studies conducted to assess these endpoints can so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4beb8615b047f965dcd379b42e2a9df7
https://doi.org/10.3109/10408440903401511
https://doi.org/10.3109/10408440903401511
Publikováno v:
General, Applied and Systems Toxicology
Noncellular blood compartment (plasma or serum) and urine biochemical components are important indicators of overall animal health and can be used in conjunction with other parameters to investigate the toxicity of drugs and chemicals. This chapter d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e382eb123afd3b3e40c52838672832c5
https://doi.org/10.1002/9780470744307.gat040
https://doi.org/10.1002/9780470744307.gat040