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pro vyhledávání: '"Lesley D. Morrison"'
Autor:
Lesley D. Morrison, Angelika Richter
Publikováno v:
Brain Research. 981:168-173
Previous studies suggested that glutamatergic overactivity contributes to the manifestation of dystonia in the dtsz mutant hamster, a model of idiopathic paroxysmal dyskinesia in which dystonic episodes occur in response to mild stress. Therefore, th
Publikováno v:
Journal of Neurochemistry. 65:636-642
Although much evidence has implicated polyamines in brain development and function, little information is available on these substances in human brain. We examined the influence of regional distribution and aging on putrescine, spermidine, and spermi
Publikováno v:
Journal of Neurochemistry. 67:1328-1331
S-Adenosylmethionine is an essential ubiquitous metabolite central to many biochemical pathways, including transmethylation and polyamine biosynthesis. Reduced CSF S-adenosylmethionine levels in Alzheimer's disease have been reported; however, no inf
Autor:
Lesley D. Morrison, Stephen J. Kish
Publikováno v:
Neuroscience Letters. 197:5-8
Despite considerable evidence implicating polyamines in CNS function, little is known about the status of the polyamine system in normal or abnormal human brain. We measured the levels of the polyamines spermidine, spermine and their precursor putres
Publikováno v:
Archives of Neurology. 51:581-584
Objective: We measured the activity of S-adenosylmethionine decarboxylase, a key regulatory enzyme of polyamine biosynthesis, in the temporal cortex of patients with epilepsy. Design: Cortical surgical specimens were obtained following anterior tempo
Publikováno v:
Mutation Research Letters. 302:45-52
The mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) following activation by ram seminal vesicle microsomes (RSVM, a source of prostaglandin H synthase, PHS) were studied in Salmonella typhimurium tester strains possessing elevated l
Publikováno v:
Brain research. Developmental brain research. 73(2)
Recent experimental animal studies have implicated brain polyamines as having roles in both brain development and human brain neurodegenerative conditions. In order to provide baseline information, in normal human brain, on one of the key polyamine s
Publikováno v:
Neuroscience letters. 154(1-2)
We measured the activity of S-adenosylmethionine decarboxylase (SAMDC), a key regulatory enzyme of polyamine biosynthesis, in autopsied brain from 13 patients with Alzheimer's Disease (AD). As compared with the controls, mean enzyme activity was incr