Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lesley Clayton"'
Aurora B switches relative strength of kinetochore–microtubule attachment modes for error correction
Publikováno v:
The Journal of Cell Biology
Doodhi et al. reconstitute the yeast kinetochore–microtubule interface in vitro and compare the relative strength of distinct kinetochore–microtubule interaction modes. Their results suggest how Aurora B kinase promotes the exchange of kinetochor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103d56f794258e00d8824aee6c3a70b1
https://doi.org/10.1083/jcb.202011117
https://doi.org/10.1083/jcb.202011117
For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles; this is called bi-orientation. To establish bi-orientation prior to chromosome segregation, any aberrant kinetochore–microtubule int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690f33071ba7c420cb805abbf189225f
https://doi.org/10.1101/455873
https://doi.org/10.1101/455873
Starting with 7.7 mg of a p-tubulin isolated from myxamoebae of the slime mould Physarum polycephalum, 90% of the sequence has been determined by the Edman degradation of peptides generated by cyanogen bromide, trypsin and Staphylococcus aureus prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591f735feeb62d158a71463135c47749
https://doi.org/10.1111/j.1432-1033.1986.tb10492.x
https://doi.org/10.1111/j.1432-1033.1986.tb10492.x
Autor:
Kayo Natsume, Akihisa Mino, Jean-François Maure, Tomoyuki Tanaka, Andrea Musacchio, Yusuke Oku, Lesley Clayton, Shinya Komoto, Sebastiano Pasqualato
Publikováno v:
Current Biology
Summary Proper chromosome segregation in mitosis relies on correct kinetochore-microtubule (KT-MT) interactions. The KT initially interacts with the lateral surface of a single MT (lateral attachment) extending from a spindle pole and is subsequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2da8e0db127788983bbe6010630c0f
https://doi.org/10.1016/j.cub.2010.12.050
https://doi.org/10.1016/j.cub.2010.12.050
Autor:
Natalia I. Arbouzova, Sakura Saburi, Sanjeev Shaw, Miriam Barrios-Rodiles, Helen McNeill, Jeff Wrana, Xaralabos Varelas, Laura Gardano, Richelle Sopko, Hitoshi Matakatsu, Elizabeth A. Silva, Seth S. Blair, Lesley Clayton
Publikováno v:
Current Biology. 19:1112-1117
Summary The Drosophila tumor suppressor gene fat encodes a large cadherin that regulates growth and a form of tissue organization known as planar cell polarity (PCP). Fat regulates growth via the Hippo kinase pathway [1–4], which controls expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb9bc70d1a7f2e22a0a5d6eb03563a3
https://doi.org/10.1016/j.cub.2009.05.049
https://doi.org/10.1016/j.cub.2009.05.049
Publikováno v:
Mechanisms of Development. 91:217-226
We have shown that the 26 bp bx1 element from the regulatory region of Distal-less is capable of imposing control by the homeotic genes Ultrabithorax and abdominal-A on a general epidermal activator in Drosophila . This provides us with an assay to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a9789dcf8f8e8ff90cbf10126115b6
https://doi.org/10.1016/s0925-4773(99)00306-8
https://doi.org/10.1016/s0925-4773(99)00306-8
Publikováno v:
Developmental Biology. 205:322-331
Polarisation of cells during mouse preimplantation development first occurs within blastomeres at the eight-cell stage, as part of a process called compaction. Cell–cell contact mediated by the cell adhesion molecule uvomorulin (E-cadherin) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54a868b0813f3fd34d7b8430f0d83f4
https://doi.org/10.1006/dbio.1998.9117
https://doi.org/10.1006/dbio.1998.9117
Autor:
Lesley Clayton, Martin H. Johnson
Publikováno v:
Experimental Cell Research. 238:450-464
Tropomyosin is an actin-binding cytoskeletal protein which has been extensively characterized in a variety of cell types and tissues, with the exception of very early developmental stages during which cellular polarization first occurs. We have ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdaa8d14dd2cd960fb15764855229f4
https://doi.org/10.1006/excr.1997.3854
https://doi.org/10.1006/excr.1997.3854
Publikováno v:
EMBO Reports
Centromeres are known to promote kinetochore assembly. However, two other roles—facilitating robust sister chromatid cohesion and advancing the replication timing of centromeric regions—have recently emerged. The three are analysed in this Review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::330ac34c832cf5cb6b7c3b1bdc378100
https://pubmed.ncbi.nlm.nih.gov/24232185
https://pubmed.ncbi.nlm.nih.gov/24232185
Publikováno v:
Molecular Reproduction and Development. 44:77-87
Compaction of the eight-cell stage mouse embryo is a critical event in the generation of different cell types within the preimplantation embryo. Uvomorulin, a member of the cadherin family of cell adhesion molecules, is important during compaction an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7079192d6c6c996d4368aaae8e263e
https://doi.org/10.1002/(sici)1098-2795(199605)44:1<77::aid-mrd9>3.0.co
https://doi.org/10.1002/(sici)1098-2795(199605)44:1<77::aid-mrd9>3.0.co