Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Lesley C. Wright"'
Autor:
L. Tomkins, Paul Holford, A. Kumari, Julianne T. Djordjevic, G. P. M. Moore, Clare Gordon-Thomson, Lesley C. Wright, Tania C. Sorrell
Publikováno v:
Cellular and Molecular Life Sciences. 66:1116-1125
Chitotriosidase secreted by activated human macrophages has been implicated in the defence against chitin-bearing pathogens. The antifungal properties of human chitotriosidase were investigated here following retroviral vector-mediated gene transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dbbea21f3ba824a3f6721c328a59eb
https://doi.org/10.1007/s00018-009-8765-7
https://doi.org/10.1007/s00018-009-8765-7
Autor:
Lesley C. Wright, Tania C. Sorrell, A. Rosemary Siafakas, Michelle Larsen, Ross A. Boadle, Julianne T. Djordjevic, Peter R. Williamson, Christabel F. Wilson
Publikováno v:
Journal of Biological Chemistry. 282:37508-37514
Phospholipase B (Plb1) is secreted by pathogenic fungi and is a proven virulence determinant in Cryptococcus neoformans. Cell-associated Plb1 is presumptively involved in fungal membrane biogenesis and remodelling. We have also identified it in crypt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fceea07677b89a703e51b3db5dcb07ed
https://doi.org/10.1074/jbc.m707913200
https://doi.org/10.1074/jbc.m707913200
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5158-5165
The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0de4d01de7ef48452ff10be4606305b
https://doi.org/10.1016/j.bmc.2007.05.028
https://doi.org/10.1016/j.bmc.2007.05.028
Autor:
Fanrong Kong, Katrina A. Jolliffe, Fred Widmer, Sharon C.-A. Chen, Zhongsheng Tong, Catriona Halliday, Zofia Guse, Ok Cha Lee, Lesley C. Wright, Tania C. Sorrell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2219-2222
The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d72b956ffebedd54a7043f2f63b7e7
https://doi.org/10.1128/aac.01382-06
https://doi.org/10.1128/aac.01382-06
Autor:
Ranjini Ganendren, Jackie Payne, Lesley C. Wright, Tania C. Sorrell, Julianne T. Djordjevic, Rosemary M. Santangelo
Publikováno v:
Eukaryotic Cell. 6:37-47
Cryptococci survive and replicate within macrophages and can use exogenous arachidonic acid for the production of eicosanoids. Phospholipase B1 (PLB1) has a putative, but uninvestigated, role in these processes. We have shown that uptake and esterifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45d084b79e8303059f431569f3fb382
https://doi.org/10.1128/ec.00262-06
https://doi.org/10.1128/ec.00262-06
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1760:1569-1579
Secreted phospholipase B enzymes (PLB1) with high levels of N-linked glycosylation are proven fungal virulence determinants. We demonstrated that removal of N-linked glycans from secreted cryptococcal PLB1 leads to loss of enzyme activity. To determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebec5937571c423ba673bea29a4dbe9
https://doi.org/10.1016/j.bbagen.2006.07.002
https://doi.org/10.1016/j.bbagen.2006.07.002
Publikováno v:
FEMS Yeast Research. 6:558-566
Proton nuclear magnetic resonance spectroscopy is a nondestructive technique that identifies chemicals in solution and in living cells. It has been used in cryptococcal research to identify the primary structure of capsular glucuronoxylomannans, link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91738e05aed3e2065f8d03782a362c3d
https://doi.org/10.1111/j.1567-1364.2006.00079.x
https://doi.org/10.1111/j.1567-1364.2006.00079.x
Publikováno v:
Microbes and Infection. 8:1006-1015
Secreted phospholipase B (PLB1), which contains three enzyme activities in the one protein, is necessary for the initiation of pulmonary infection by Cryptococcus neoformans and for dissemination from the lung via the lymphatics and blood. Adhesion t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e49ae69e28b2f92f63585069e86954
https://doi.org/10.1016/j.micinf.2005.10.018
https://doi.org/10.1016/j.micinf.2005.10.018
Autor:
Lesley C. Wright, Tania C. Sorrell, Fred Widmer, Ranjini Ganendren, Daniel Obando, Rosemary Handke, David Ellis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:414-421
The alkyl phosphocholine drug miltefosine is structurally similar to natural substrates of the fungal virulence determinant phospholipase B1 (PLB1), which is a potential drug target. We determined the MICs of miltefosine against key fungal pathogens,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f77e6e69375c23f0e5ed957161fb114
https://doi.org/10.1128/aac.50.2.414-421.2006
https://doi.org/10.1128/aac.50.2.414-421.2006
Autor:
Katrina A. Jolliffe, Fred Widmer, Lesley C. Wright, Tania C. Sorrell, Clarissa K. L. Ng, Daniel Obando
Publikováno v:
Journal of Medicinal Chemistry. 49:811-816
A series of bisquaternary ammonium salts with a 12-carbon spacer between the positive charges were synthesized, and their antifungal activity has been investigated. Compounds with butyl, pentyl, and isopentyl headgroups were the most potent antifunga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba04eeb3f8f484b372bf54536ff94afe
https://doi.org/10.1021/jm0508843
https://doi.org/10.1021/jm0508843