Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lesley C Dupuy"'
Autor:
Callie E Bounds, Steven A Kwilas, Ana I Kuehne, Jennifer M Brannan, Russell R Bakken, John M Dye, Jay W Hooper, Lesley C Dupuy, Barry Ellefsen, Drew Hannaman, Hua Wu, Jin-an Jiao, Eddie J Sullivan, Connie S Schmaljohn
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137786 (2015)
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs) that recognize both viruses
Externí odkaz:
https://doaj.org/article/ac140de6098145798297764eabc0b4e8
Autor:
Callie E. Bounds, Frances E. Terry, Leonard Moise, Drew Hannaman, William D. Martin, Anne S. De Groot, John J. Suschak, Lesley C. Dupuy, Connie S. Schmaljohn
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 12, Pp 2824-2836 (2017)
Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of Ven
Externí odkaz:
https://doaj.org/article/2fcf98a6e1194228a8f8a86a094e1006
Autor:
Daniel A. J. Mitchell, Lesley C. Dupuy, Mariano Sanchez-Lockhart, Gustavo Palacios, Jaap W. Back, Katya Shimanovskaya, Sidhartha Chaudhury, Daniel R. Ripoll, Anders Wallqvist, Connie S. Schmaljohn
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 12, Pp 2883-2893 (2017)
We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibo
Externí odkaz:
https://doaj.org/article/0a9837c1389a4c82a0650b28fe6135ea
Autor:
Daniel R. Ripoll, Daniel A. J. Mitchell, Lesley C. Dupuy, Anders Wallqvist, Connie Schmaljohn, Sidhartha Chaudhury
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 12, Pp 2953-2966 (2017)
Ebola virus (EBOV) infection is highly lethal and results in severe febrile bleeding disorders that affect humans and non-human primates. One of the therapeutic approaches for treating EBOV infection focus largely on cocktails of monoclonal antibodie
Externí odkaz:
https://doaj.org/article/c4dfe486ca574ecea3778f2437d9e1ea
Autor:
Kristin Spik, Lesley C. Dupuy, John J. Suschak, Steven A. Kwilas, Charles J. Shoemaker, James A. Williams, Connie S. Schmaljohn, Carolyn Six
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 810-821 (2020)
DNA vaccines expressing codon-optimized Venezuelan equine encephalitis virus (VEEV) and Ebola virus (EBOV) glycoprotein genes provide protective immunity to mice and nonhuman primates when delivered by intramuscular (IM) electroporation (EP). To achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b4fdd326aaa2580336a411f0d33ae6
https://doi.org/10.1016/j.omtm.2020.04.009
https://doi.org/10.1016/j.omtm.2020.04.009
Autor:
Peter W. Mason, Clayton W. Beard, Lesley C. Dupuy, Jeffrey B. Ulmer, Dong Yu, Carolyn M. Six, Andrew Geall, Connie S. Schmaljohn, Marcelo M. Samsa
Publikováno v:
Molecular Therapy. 27:850-865
Venezuelan equine encephalitis virus (VEEV) is a known biological defense threat. A live-attenuated investigational vaccine, TC-83, is available, but it has a high non-response rate and can also cause severe reactogenicity. We generated two novel VEE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c60119f751632d1516de037d1e52ee
https://doi.org/10.1016/j.ymthe.2018.12.013
https://doi.org/10.1016/j.ymthe.2018.12.013
Autor:
Connie S. Schmaljohn, Lesley C. Dupuy, Carolyn Six, Kristin Spik, Steven A. Kwilas, Kenneth Bagley, John J. Suschak, Charles J. Shoemaker
Publikováno v:
Antiviral Research. 159:113-121
We have previously shown that DNA vaccines expressing codon-optimized alphavirus envelope glycoprotein genes protect both mice and non-human primates from viral challenge when delivered by intramuscular electroporation (IM-EP). To determine if we cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a16b68356ee6a63aa22bd19a651abd3
https://doi.org/10.1016/j.antiviral.2018.09.014
https://doi.org/10.1016/j.antiviral.2018.09.014
Autor:
Sidhartha Chaudhury, Daniel R. Ripoll, Connie S. Schmaljohn, Mariano Sanchez-Lockhart, Katya Shimanovskaya, Anders Wallqvist, Daniel A. J. Mitchell, Jaap W. Back, Lesley C. Dupuy, Gustavo Palacios
Publikováno v:
Human Vaccines & Immunotherapeutics
We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934469149c45ab924c7758da5f2497b2
https://doi.org/10.1080/21645515.2017.1347740
https://doi.org/10.1080/21645515.2017.1347740
Autor:
Lesley C. Dupuy, Leonard Moise, Frances Terry, William D. Martin, Anne S. De Groot, John J. Suschak, Connie S. Schmaljohn, Drew Hannaman, Callie E. Bounds
Publikováno v:
Human Vaccines & Immunotherapeutics
Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of Ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc1c5fffdb8ecc2481526acb9539513
https://doi.org/10.1080/21645515.2017.1329788
https://doi.org/10.1080/21645515.2017.1329788
Publikováno v:
Vaccine. 34:3607-3612
Venezuelan equine encephalitis virus (VEEV), a mosquito-borne alphavirus, causes periodic epizootics in equines and is a recognized biological defense threat for humans. There are currently no FDA-licensed vaccines against VEEV. We developed a candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3db78fe7ea34d51fc6d7c8a81d170d
https://doi.org/10.1016/j.vaccine.2016.04.077
https://doi.org/10.1016/j.vaccine.2016.04.077