Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lesley Alpert"'
Publikováno v:
International Journal of Gynecological Pathology. 26:160-164
BRCA2 germ-line mutations confer an increased risk of developing breast and ovarian cancer. We report the occurrence of a mixed ovarian germ cell tumor (GCT) (50% embryonal carcinoma, 20%-25% choriocarcinoma, 10%-15% dysgerminoma, and 10%-15% immatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6775ce8cf27d614b1db20a06c60a8112
https://doi.org/10.1097/01.pgp.0000228142.52054.0f
https://doi.org/10.1097/01.pgp.0000228142.52054.0f
Publikováno v:
The Breast Journal. 11:326-332
Columnar cell change (CCC) is common and has often been considered of little clinical interest. However, some investigators have suggested that it may be a marker for increased risk of breast cancer. To see whether CCC is subject to hormonal influenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1776c8c90ceb839107bf248028b888
https://doi.org/10.1111/j.1075-122x.2005.21698.x
https://doi.org/10.1111/j.1075-122x.2005.21698.x
Publikováno v:
Digestive Diseases and Sciences. 50:196-200
Liver involvement in sarcoidosis is relatively common, with most biopsies showing granulomas. Classical liver disease is, however, unusual (1). While cholestasis is the most frequent manifestation (2), its presentation as the first sign of this disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd0bebf119bb52a9eb8b95a5a03cfbe
https://doi.org/10.1007/s10620-005-1300-2
https://doi.org/10.1007/s10620-005-1300-2
Autor:
Lorraine E. Chalifour, Nicolas Servant, Chunlei Wang, Gordon M. Kirby, Stevan Dostanic, Martin Bernier, Lesley Alpert, Stéphanie Héon
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 285:H499-H506
Doxorubicin (DOX), an anticancer drug, causes a dose-dependent cardiotoxicity. Some evidence suggests that female children have an increased risk for DOX-mediated cardiac damage. To determine whether the iron chelator dexrazoxane (DXR) could reduce D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3190c809f0f22873a81f3c73ef716886
https://doi.org/10.1152/ajpheart.00047.2003
https://doi.org/10.1152/ajpheart.00047.2003
Autor:
Lesley Alpert, Martin J. Black, William D. Foulkes, Ala-Eddin Al Moustafa, Moulay A. Alaoui-Jamali, Corinne Serruya, Gerald Batist, Robert Sladek, Maite Hernandez-Perez
Publikováno v:
Oncogene. 21:2634-2640
In order to identify genes involved in head and neck carcinogenesis, we compared the gene expression profile in matched primary normal epithelial cells and primary head and neck cancer cells from the same patients. A cDNA microarray analysis consisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d531356824339661c71d003e014d6de
https://doi.org/10.1038/sj.onc.1205351
https://doi.org/10.1038/sj.onc.1205351
Publikováno v:
Cancer Letters. 177:65-74
Glutathione S-transferase (GST) mu phenotype was assessed in colon tissue from patients with ulcerative colitis and colorectal neoplasms that were positive for GSTM1 genotype. GST mu protein (enzyme linked immunosorbent assay) was absent in 2/9 unaff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a770c3ff79bee1c9276e2db578d17f9
https://doi.org/10.1016/s0304-3835(01)00765-0
https://doi.org/10.1016/s0304-3835(01)00765-0
Publikováno v:
Journal of Endocrinology. 171:109-118
Prostate cancer is the most diagnosed invasive malignancy in males. Androgens and oestrogens have been implicated in the pathogenesis of prostate cancer. We report herein that the pure anti-oestrogen ICI 182,780 (ICI) reduces Ki-67 labelling index an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4614f4cc41179ffef160e5a48f2ce7
https://doi.org/10.1677/joe.0.1710109
https://doi.org/10.1677/joe.0.1710109
Autor:
Daniela Marcantonio, Lorraine E. Chalifour, Moulay A. Alaoui-Jamali, Lesley Alpert, Hung The Huynh
Publikováno v:
Endocrinology. 142:2409-2418
Estrogens play a role in mammary gland function and are implicated in mammary carcinogenesis. We report the cloning of a novel gene [steroid-sensitive gene 1 (SSG1)] that is regulated by E(2) in the rat uterus and mammary gland. The full-length SSG1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db86ad31bd2fe5103871ea080b7917d1
https://doi.org/10.1210/endo.142.6.8154
https://doi.org/10.1210/endo.142.6.8154
Autor:
Nacéra Saadane, Gordon M. Kirby, Benjamin Mitmaker, Lorraine E. Chalifour, Lesley Alpert, Ping Yue
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 79:533-544
Doxorubicin (DOX) and VP16 are DNA topoisomerase II inhibitors yet only DOX induces an irreversible cardiotoxicity, likely through DOX-induced oxidative stress. Egr-1 is overexpressed after many stimuli that increase oxidative stress in vitro and aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db90a2e64fd63a3e27fb3fb34c987bc9
https://doi.org/10.1139/y01-021
https://doi.org/10.1139/y01-021
Autor:
Betty L. Slagle, Nasser Fotouhi-Ardakani, Lesley Alpert, Maite Hernandez Perez, Naciba Benlimame, Jacques Galipeau, Moulay A. Alaoui-Jamali, Iris Jaitovich-Groisman, Daniel J. Song
Publikováno v:
Journal of Biological Chemistry. 276:14124-14132
Human hepatitis B virus is a risk factor for the development of hepatocellular carcinoma. The hepatitis B virus x protein (HBx) has been shown to inactivate the p53 tumor suppressor protein and impair DNA repair, cell cycle, and apoptosis mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72aafaf253eb79fa4c232c7566de31ba
https://doi.org/10.1074/jbc.m010852200
https://doi.org/10.1074/jbc.m010852200