Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis

Autor: Jingyu Chen, Lesley A. Stark

Publikováno v: Cells, Vol 7, Iss 10, p 157 (2018)

Nucleoli are emerging as key sensors of cellular stress and regulators of the downstream consequences on proliferation, metabolism, senescence, and apoptosis. NF-κB signalling is activated in response to a similar plethora of stresses, which leads t

Externí odkaz: https://doaj.org/article/6b1599723aca49e78874420f81c75632

Data from Nucleolar Targeting of RelA(p65) Is Regulated by COMMD1-Dependent Ubiquitination

Autor: Lesley A. Stark, Malcolm G. Dunlop, Karina Reinhardt, Alexandra Clipson, James Simpson, Carolyn J. Loveridge, Hazel C. Thoms

Stimulation of the NF-κB pathway can have proapoptotic or antiapoptotic consequences, and one mechanism that determines the outcome is the nuclear distribution of RelA. Certain stress stimuli induce nucleolar accumulation of RelA thereby mediating a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34a9b06841960e8f0c574caf168b7b94
https://doi.org/10.1158/0008-5472.c.6499866.v1

Supplementary Figure 1 from Nucleolar Targeting of RelA(p65) Is Regulated by COMMD1-Dependent Ubiquitination

Autor: Lesley A. Stark, Malcolm G. Dunlop, Karina Reinhardt, Alexandra Clipson, James Simpson, Carolyn J. Loveridge, Hazel C. Thoms

Supplementary Figure 1 from Nucleolar Targeting of RelA(p65) Is Regulated by COMMD1-Dependent Ubiquitination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e26d71e3c7515c3d1f8abf1b1ebd6c6
https://doi.org/10.1158/0008-5472.22381431.v1

A Role for the Autophagic Receptor, SQSTM1/p62, in Trafficking NF-κB/RelA to Nucleolar Aggresomes

Autor: Hazel C. Thoms, Rory R. Duncan, Ian T Lobb, Jimi Wills, Lesley A. Stark, Pierre Morin, Kirsty J. Martin, Karl C.F. Olsen, Xhordi Lleshi

Publikováno v: Lobb, I T, Morin, P, Martin, K J, Thoms, H, Wills, J, Lieshi, X, Olsen, K C F, Duncan, R R & Stark, L A 2020, ' A role for the autophagic receptor, SQSTM1/p62, in trafficking NF-κB/RelA to nucleolar aggresomes ', Molecular Cancer Research . https://doi.org/10.1158/1541-7786.MCR-20-0336

Elevated NF-κB activity is a contributory factor in many hematologic and solid malignancies. Nucleolar sequestration of NF-κB/RelA represses this elevated activity and mediates apoptosis of cancer cells. Here, we set out to understand the mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979d7c7612e5b31887672be9adaf93f2
https://pubmed.ncbi.nlm.nih.gov/33097627

Insights into the Relationship between Nucleolar Stress and the NF-κB Pathway

Autor: Lesley A. Stark, Jingyu Chen

Publikováno v: Chen, J & Stark, L A 2019, ' Insights into the Relationship between Nucleolar Stress and the NF-kappa B Pathway ', Trends in Genetics, vol. 35, no. 10, pp. 768-780 . https://doi.org/10.1016/j.tig.2019.07.009

The nuclear organelle the nucleolus and the transcription factor nuclear factor of kappa-light-chain-enhancer of activated B cells (NF-kappa B) are both central to the control of cellular homeostasis, dysregulated in common diseases and implicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d078635e7c023dbc025514f45187fa
https://pubmed.ncbi.nlm.nih.gov/31434627