Výsledky vyhledávání - "Lesley A. Stanley"

Akademický článek

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.

Autor: Nicola Laurieri, Julien Dairou, James E Egleton, Lesley A Stanley, Angela J Russell, Jean-Marie Dupret, Edith Sim, Fernando Rodrigues-Lima

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96370 (2014)

Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its muri

Externí odkaz: https://doaj.org/article/b8cd1ae39b694784a483f07e8ddb3bf1

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Arylamine N-Acetyltransferases in Normal and Abnormal Embryonic Development

Autor: Lesley A. Stanley, Edith Sim

Publikováno v: Arylamine N-acetyltransferases in Health and Disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22a2779b33717b19a3fc046bab95e55b
https://doi.org/10.1142/9789813232013_0005

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Evidence That the Capacity of Nongenotoxic Carcinogens to Induce Oxidative Stress Is Subject to Marked Variability

Autor: Colin J. Henderson, Amy R. Cameron, Lynsey R. Chatham, Lesley A. Stanley, Charles Roland Wolf

Publikováno v: Toxicological Sciences

Many drugs and environmental chemicals which are not directly mutagenic have the capacity to increase the incidence of tumors in the liver and other tissues. For this reason, such compounds are known as nongenotoxic carcinogens. The mechanisms underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f005390ab0e3c393960537cbd879887f
http://europepmc.org/articles/PMC4833039

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The European Registered Toxicologist (ERT): Current status and prospects for advancement

Publikováno v: Toxicology Letters, 259, 151-5
Toxicology Letters, 259, pp. 151-5
Wilks, M F, Blaauboer, B J, Schulte-Hermann, R, Wallace, H M, Galli, C L, Haag-Grönlund, M, Matović, V, Teixeira, J P, Zilliacus, J, Basaran, N, Bonefeld-Jørgensen, E C, Bourrinet, P, Brueller, W, Claude, N, Miranda, J P, Gundert-Remy, U, Håkansson, H, Kovatsi, L, Liesivuori, J, Lindeman, B, Lison, D, Leconte, I, Martínez-López, E, Murias, M, Michel, C, Scheepers, P T J, Stanley, L & Tsatsakis, A 2016, ' The European Registered Toxicologist (ERT) : Current status and prospects for advancement ', Toxicology Letters, vol. 259, pp. 151-5 . https://doi.org/10.1016/j.toxlet.2016.06.014

Item does not contain fulltext Following its inception in 1994, the certification of European Registered Toxicologists (ERT) by EUROTOX has been recognized as ensuring professional competence as well as scientific integrity and credibility. Criteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628c04a88a36dff4a313042b7e4afdf1
https://hdl.handle.net/10400.18/4070

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Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior

Autor: C. Roland Wolf, Lesley A. Stanley, Brian C. Horsburgh, Nico Scheer, Jillian Ross

Publikováno v: Drug Metabolism Reviews. 41:27-65

In this paper, we evaluate methodologies and null mouse models used to study drug transporter function in vitro and in vivo. P-glycoprotein and MRP null mice have been used to examine many aspects of xenobiotic distribution and bioavailability. Their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b6a35858543f097cf02e0ac5a728db
https://doi.org/10.1080/03602530802605040

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Update on the pharmacogenetics of NATs: structural considerations

Autor: Edith Sim, Lesley A. Stanley

Publikováno v: Pharmacogenomics. 9:1673-1693

The arylamine N-acetyltransferase (NAT) genes encode enzymes that catalyze the N-acetylation of aromatic amines and hydrazines and the O-acetylation of heterocyclic amines. These genes, which play a key role in cellular homeostasis as well as in gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488db1ff965eca9a09c2d6366542a14f
https://doi.org/10.2217/14622416.9.11.1673

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PXR and CAR: Nuclear Receptors which Play a Pivotal Role in Drug Disposition and Chemical Toxicity

Autor: Lesley A. Stanley, C. Roland Wolf, Nico Scheer, Brian C. Horsburgh, Jillian Ross

Publikováno v: Drug Metabolism Reviews. 38:515-597

Xenobiotic metabolism and detoxification is regulated by receptors (e.g., PXR, CAR) whose characterization has contributed significantly to our understanding of drug responses in humans. Technologies facilitating the screening of compounds for recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71843f88f74e091292359df9ef21ca05
https://doi.org/10.1080/03602530600786232

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Lack of evidence for metabolism of p-phenylenediamine by human hepatic cytochrome P450 enzymes

Autor: Edward Doyle, Robert Powrie, Lesley A. Stanley, Diane D’Angelo, Clifford R. Elcombe, Julie A. Skare

Publikováno v: Toxicology. 210:147-157

p-Phenylenediamine (PPD) is a widely used ingredient in permanent hair dyes; however, little has been published on its metabolism, especially with respect to hepatic cytochrome P450 (CYP)-mediated oxidation. This is regarded as a key step in the acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ec9efe1843c6ea14b5160d328b3d56
https://doi.org/10.1016/j.tox.2005.01.019

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