Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lesley A. Pearce"'
Autor:
Tashbib, Khan, Nicholas J, Lyons, Madeline, Gough, Kayden K X, Kwah, Tahleesa J, Cuda, Cameron E, Snell, Brian W, Tse, Kamil A, Sokolowski, Lesley A, Pearce, Timothy E, Adams, Stephen E, Rose, Simon, Puttick, Marina, Pajic, Mark N, Adams, Yaowu, He, John D, Hooper, Thomas, Kryza
Publikováno v:
Theranostics. 12:6915-6930
Autor:
Timothy E. Adams, Paul S. Donnelly, Rodney J. Hicks, Charlotte C. Williams, Anna Raicevic, Stacey E Rudd, Jessica Van Zuylekom, Carleen Cullinane, Lesley A. Pearce
Publikováno v:
Chemical Science
Identification of tumors which over-express Epidermal Growth Factor Receptor (EGFR) is important in selecting patients for anti-EGFR therapies. Enzymatic bioconjugation was used to introduce positron-emitting radionuclides (89Zr, 64Cu) into an anti-E
Autor:
Charlotte C. Williams, Simon Puttick, Nicholas Lyons, Lesley A. Pearce, Lewis Perrin, Thomas Hodgkinson, Tashbib Khan, Trent P. Munro, Sinead Barry, Michael D. Lee, Timothy E. Adams, C. Blake Gilks, Thomas Kryza, Rohan Lourie, Claire M. Davies, Yaowu He, Madeline Gough, John D. Hooper, Justin B. Goh, Martina L. Jones, Rebecca Rogers, Naven Chetty
Publikováno v:
Molecular pharmaceutics. 18(9)
Optimal cytoreduction for ovarian cancer is often challenging because of aggressive tumor biology and advanced stage. It is a critical issue since the extent of residual disease after surgery is the key predictor of ovarian cancer patient survival. F
Autor:
Simon Puttick, Lesley A. Pearce, Michael D. Lee, Wing Yin Tong, Arghavan Golbaz-Hagh, Charlotte C. Williams, Tam Pham, Thomas Nebl, Timothy E. Adams, Stephen E. Rose
Publikováno v:
Bioconjugate Chemistry. 30:2539-2543
The functionalization of proteins with different cargo molecules is highly desirable for a broad range of applications. However, the reproducible production of defined conjugates with multiple functionalities is a significant challenge. Herein, we re
Autor:
Sameer A. Greenall, Harley I. Kornblum, Shengnan C Chen, Olan Dolezal, Lesley A. Pearce, Ekatarina Seminova, Mathew McKenzie, Timothy E. Adams, Terrance Grant Johns, Mani Kuchibhotla, Raelene Endersby, Kerrie L. McDonald, John D. Bentley
Publikováno v:
Neuro Oncol
Background Although epidermal growth factor receptor (EGFR) and its truncated, autoactive mutant EGFR variant (v)III are bona fide drivers of tumorigenesis in some gliomas, therapeutic antibodies developed to neutralize this axis have not improved pa
Autor:
Ariel Isaacs, Naphak Modhiran, James G. Barnes, Christopher L. D. McMillan, Koert J. Stittelaar, Tram Phan, Patrick C. Reading, Geert van Amerongen, Francesca L Mordant, Stacey T. M. Cheung, Connor Scott, Eve Radunz, Daniel Watterson, Louis Lu, Alberto A. Amarilla, Lukasz Kowalczyk, Mai Tran, Mallory Daleris, David A. Brockman, Marianne Gillard, Sherry J. Morgan, Zheyi Li, Noushin Jaberolansar, Julia Lackenby, Michael S. Avumegah, David Edwards, Kym Hoger, Karen Hughes, Judith A. Scoble, Charani Ranasinghe, Qi Zhou, Danushka K. Wijesundara, Fernando Villalon Letelier, Martina L. Jones, Ben Hughes, Kanta Subbarao, Mylinh La, Keith J. Chappell, Summa Bibby, Peter Tapley, Andrew Young, Cora Lau, Lesley A. Pearce, Tam Pham, Trent P. Munro, Paul R. Young, Alexander A. Khromykh, Justin B. Goh, Kate Guilfoyle
Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace with more than 30 candidate vaccines now in clinical evaluation. Here we describe the preclinical development of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f9211287e21428829cd16fc490c77f
https://doi.org/10.21203/rs.3.rs-68892/v1
https://doi.org/10.21203/rs.3.rs-68892/v1
Autor:
Francesca L Mordant, Danushka K. Wijesundara, Keith J. Chappell, Cora Lau, Naphak Modhiran, Kanta Subbarao, Stacey T. M. Cheung, Ariel Isaacs, Charani Ranasinghe, Julia Lackenby, Martina L. Jones, Qi Zhou, Eve Radunz, James G. Barnes, Kate Guilfoyle, Koert J. Stittelaar, Zheyi Li, Peter Tapley, Justin B. Goh, Tram Phan, Karen Hughes, Judith M. A. van den Brand, Noushin Jaberolansar, Benjamin S. Hughes, Sherry J. Morgan, Connor A. P. Scott, Judith A. Scoble, Trent P. Munro, Tam Pham, Patrick C. Reading, Mai H. Tran, Andrew Young, Fernando Villalón-Letelier, Marianne Gillard, Lesley A. Pearce, Michael S. Avumegah, Mylinh La, Summa Bibby, Christopher L. D. McMillan, Daniel Watterson, Lukasz Kowalczyk, Mallory Daleris, Paul R. Young, Louis Lu, Alberto A. Amarilla, Alexander A. Khromykh, David Edwards, Kym Hoger, Geert van Amerongen, David A. Brockman
Publikováno v:
SSRN Electronic Journal.
Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace. Here we describe rational antigen design through to manufacturability and vaccine efficacy, of a prefusion-stabili
Autor:
Katrina Ngui, Peter E. Czabotar, Alana M. Neale, Esther Bandala-Sanchez, Timothy E. Adams, Naiara G. Bediaga, Andrea Maggioni, Lauren A Hartley-Tassell, Thomas Haselhorst, Lesley A. Pearce, Natalie L. Stone, Gaetano Naselli, Ahmad Wardak, Ethan D. Goddard-Borger, Leonard C. Harrison
Publikováno v:
Proceedings of the National Academy of Sciences. 115:7783-7788
CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble form following T cell activation and binds to the Siglec (sialic acid-binding Ig-like lectin)-10 receptor on T cells to suppress their function. We show that bind
Autor:
Victor A. Streltsov, Lesley A. Pearce, Meghan Hattarki, Colin L. Masters, J.N. Varghese, Rebecca M. Nisbet, Natalia Davydova, Remy Robert, Joanne M. Caine, Stewart N Nuttall, Olan Dolezal
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:1748-1758
Alzheimer's disease is the most common form of dementia in humans and is related to the accumulation of the amyloid-β (Aβ) peptide and its interaction with metals (Cu, Fe, and Zn) in the brain. Crystallographic structural information about Aβ pept
Autor:
Lesley A. Pearce, Xiaowen Xiao, Sameer A. Greenall, Nicola A. Bartone, Lindsay G. Sparrow, Leah J. Cosgrove, John D. Bentley, Robert C. Baxter, Timothy E. Adams, Judith A. Scoble
Publikováno v:
Journal of Biological Chemistry. 288:59-68
Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I. Its expression in humans is tightly controlled by maternal imprinting, a genetic restraint