Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Lesley A. Mathews Griner"'
Autor:
Dandan Li, Anne M. Miermont, Rushikesh Sable, Humair S. Quadri, Lesley A. Mathews Griner, Scott E. Martin, Taivan Odzorig, Soumita De, Marc Ferrer, Astin S. Powers, Stephen M. Hewitt, Udo Rudloff
Publikováno v:
Molecular Cancer Research. 21:316-331
Combinatorial molecular therapy in pancreatic ductal adenocarcinoma (PDAC) has yielded largely disappointing results in clinical testing to-date as a multitude of adaptive resistance mechanisms is making selection of patients via molecular markers th
Autor:
Kevin J. Frankowski, Samarjit Patnaik, Chen Wang, Noel Southall, Dipannita Dutta, Soumitta De, Dandan Li, Christopher Dextras, Yi-Han Lin, Marthe Bryant-Connah, Danielle Davis, Feijun Wang, Leah M. Wachsmuth, Pranav Shah, Jordan Williams, Md Kabir, Edward Zhu, Bolormaa Baljinnyam, Amy Wang, Xin Xu, John Norton, Marc Ferrer, Steve Titus, Anton Simeonov, Wei Zheng, Lesley A. Mathews Griner, Ajit Jadhav, Jeffrey Aubé, Mark J. Henderson, Udo Rudloff, Frank J. Schoenen, Sui Huang, Juan J. Marugan
Publikováno v:
J Med Chem
The perinucleolar compartment (PNC) is a dynamic subnuclear body found at the periphery of the nucleolus. The PNC is enriched with RNA transcripts and RNA-binding proteins, reflecting different states of genome organization. PNC prevalence positively
Autor:
Udo Rudloff, Stephen M. Hewitt, Astin S. Powers, Marc Ferrer, Soumita De, Taivan Odzorig, Scott E. Martin, Lesley A. Mathews Griner, Humair S. Quadri, Rushikesh Sable, Anne M. Miermont, Dandan Li
Secondary validation of candidate genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe0202c8c1b1c2f47cd5bfd9278fde5
https://doi.org/10.1158/1541-7786.22552189
https://doi.org/10.1158/1541-7786.22552189
Autor:
Udo Rudloff, Stephen M. Hewitt, Astin S. Powers, Marc Ferrer, Soumita De, Taivan Odzorig, Scott E. Martin, Lesley A. Mathews Griner, Humair S. Quadri, Rushikesh Sable, Anne M. Miermont, Dandan Li
Resistance to MEK inhibition in YAPC cells is not due to reactivation of phospho-Extracellular-signal-regulated-kinases (ERK) levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561c81b86a81b7e57411fa9b038ca34e
https://doi.org/10.1158/1541-7786.22552192.v1
https://doi.org/10.1158/1541-7786.22552192.v1
Autor:
Udo Rudloff, Stephen M. Hewitt, Astin S. Powers, Marc Ferrer, Soumita De, Taivan Odzorig, Scott E. Martin, Lesley A. Mathews Griner, Humair S. Quadri, Rushikesh Sable, Anne M. Miermont, Dandan Li
Schematic layout of the selumetinib versus 26 compounds targeting effector signaling of CNKSR1 screen; and Dose response of MK-2206 and rapamycin in the pancreas cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d47acfa4e5f512eee2ede94c8c93999
https://doi.org/10.1158/1541-7786.22552174.v1
https://doi.org/10.1158/1541-7786.22552174.v1
Autor:
Udo Rudloff, Stephen M. Hewitt, Astin S. Powers, Marc Ferrer, Soumita De, Taivan Odzorig, Scott E. Martin, Lesley A. Mathews Griner, Humair S. Quadri, Rushikesh Sable, Anne M. Miermont, Dandan Li
MEK blockade fails to disrupt protein-protein interactions of CNKSR1, KSR1/2, and MEK in CNKSR1low cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7370a485d13f06f320aa3bcc94e470
https://doi.org/10.1158/1541-7786.22552177
https://doi.org/10.1158/1541-7786.22552177
Autor:
Udo Rudloff, Stephen M. Hewitt, Astin S. Powers, Marc Ferrer, Soumita De, Taivan Odzorig, Scott E. Martin, Lesley A. Mathews Griner, Humair S. Quadri, Rushikesh Sable, Anne M. Miermont, Dandan Li
Lists of cell lines, antibodies, RNAi kinome screen; and matrix drug combination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da43ec6520c5ea5999715ba8cfa37149
https://doi.org/10.1158/1541-7786.22552171.v1
https://doi.org/10.1158/1541-7786.22552171.v1
Autor:
Udo Rudloff, Craig J. Thomas, Marc Ferrer, Jeffrey Aubé, Steven A. Rogers, Paresma Patel, Jian-kang Jiang, Dandan Li, Astin S. Powers, Holger Pflicke, Hong-Wu Xin, Paul Shinn, Rajarshi Guha, Vivek Shukla, Taylor J. Aiken, Lesley A. Mathews Griner, Yaroslav Teper, Yansong Bian
Suppl. Fig. 1: Procedures for synthesis of NCGC00188382 (Inhibitor#1) Suppl. Fig. 2: qPCR array of 96 stem cell genes from PANC1 adherent and PANC1 spheroids reveal up-regulation of six stem cell genes in organotypic Panc1 spheres. Suppl. Fig. 3: Inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29c837ea26c77693a9c700ef66f4593
https://doi.org/10.1158/1535-7163.22506210.v1
https://doi.org/10.1158/1535-7163.22506210.v1
Autor:
Udo Rudloff, Craig J. Thomas, Marc Ferrer, Jeffrey Aubé, Steven A. Rogers, Paresma Patel, Jian-kang Jiang, Dandan Li, Astin S. Powers, Holger Pflicke, Hong-Wu Xin, Paul Shinn, Rajarshi Guha, Vivek Shukla, Taylor J. Aiken, Lesley A. Mathews Griner, Yaroslav Teper, Yansong Bian
Pancreatic cancer remains an incurable condition. Its progression is driven, in part, by subsets of cancer cells that evade the cytotoxic effects of conventional chemotherapies. These cells are often low-cycling, multidrug resistant, and adopt a stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e21950819e835c195e9bc54f304d464
https://doi.org/10.1158/1535-7163.c.6538326
https://doi.org/10.1158/1535-7163.c.6538326
Autor:
Udo Rudloff, Stephen M. Hewitt, Astin S. Powers, Marc Ferrer, Soumita De, Taivan Odzorig, Scott E. Martin, Lesley A. Mathews Griner, Humair S. Quadri, Rushikesh Sable, Anne M. Miermont, Dandan Li
CNKSR1 promotes MEK inhibition-induced AKT activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f41b8eab503323929397805d6c848be
https://doi.org/10.1158/1541-7786.22495212.v1
https://doi.org/10.1158/1541-7786.22495212.v1