Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lesley A. Kane"'
Autor:
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick CG Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez
Publikováno v:
eLife, Vol 12 (2024)
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR ac
Externí odkaz:
https://doaj.org/article/6521500dd1424027bebffc6920eba56b
Autor:
Robert A. Craig, Brian M. Fox, Cheng Hu, Katrina W. Lexa, Maksim Osipov, Arun P. Thottumkara, Martin Larhammar, Takashi Miyamoto, Anil Rana, Lesley A. Kane, Ernie Yulyaningsih, Hilda Solanoy, Hoang Nguyen, Roni Chau, Timothy Earr, Yuji Kajiwara, Daniel Fleck, Anthony Lucas, Patrick C. G. Haddick, Ryan H. Takahashi, Vincent Tong, Jing Wang, Mark J. Canet, Suresh B. Poda, Kimberly Scearce-Levie, Ankita Srivastava, Zachary K. Sweeney, Musheng Xu, Rui Zhang, Jianrong He, Yanan Lei, Zheng Zhuo, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 65:16290-16312
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative diseases. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba59c66263d4a021ad8e4342b49383cd
https://doi.org/10.1021/acs.jmedchem.2c01056
https://doi.org/10.1021/acs.jmedchem.2c01056
Autor:
Takashi Miyamoto, Chaeyoung Kim, Johann Chow, Jason C Dugas, Jack DeGroot, Alex L Bagdasarian, Arun P Thottumkara, Martin Larhammar, Meredith EK Calvert, Brian M Fox, Joseph W Lewcock, Lesley A Kane
Sterile alpha and TIR motif containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD+ following injury. Recent work has defined the structure and catalytic activity of SARM1, yet the specific pathways cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e35b7fbb06d4ec2a209ab18294d6048
https://doi.org/10.1101/2022.04.27.489702
https://doi.org/10.1101/2022.04.27.489702
Autor:
Praveen Balabaskaran Nina, Natalya V Dudkina, Lesley A Kane, Jennifer E van Eyk, Egbert J Boekema, Michael W Mather, Akhil B Vaidya
Publikováno v:
PLoS Biology, Vol 8, Iss 7, p e1000418 (2010)
The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex.
Externí odkaz:
https://doaj.org/article/bdb33ee44c444093ade0eeb24b111a9c
Autor:
Shireen A. Sarraf, Lesley A. Kane, Adam I. Fogel, Michael Lazarou, Koji Yamano, Soojay Banerjee, Yan Li, Richard J. Youle
Publikováno v:
The Journal of Cell Biology
PINK1 phosphorylates ubiquitin, which then binds to Parkin and activates its E3 ligase activity, leading to induction of selective autophagy of damaged mitochondria.
PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autop
PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb97e47e4cc04771bc1e4d271442345
https://doi.org/10.1083/jcb.201402104
https://doi.org/10.1083/jcb.201402104
Publikováno v:
Developmental Cell. 22(2):320-333
SummaryMutations in the mitochondrial kinase PINK1 and the cytosolic E3 ligase Parkin can cause Parkinson's disease. Damaged mitochondria accumulate PINK1 on the outer membrane where, dependent on kinase activity, it recruits and activates Parkin to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2d39abb726f42627d6e7dfd2c5b3dc
Autor:
Lesley A. Kane, Chunxin Wang, Derek P. Narendra, Richard J. Youle, Michael Lazarou, Seok Min Jin
Publikováno v:
The Journal of Cell Biology
Differential localization to the inner and outer mitochondrial membranes regulates PINK1 stability and function.
PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson’s disease. It has been found to work in the same pathw
PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson’s disease. It has been found to work in the same pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b7a1db92d64fb26e974eb4e0def411
https://doi.org/10.1083/jcb.201008084
https://doi.org/10.1083/jcb.201008084
Publikováno v:
Autophagy. 6:1090-1106
Mitochondria sustain damage with aging, and the resulting mitochondrial dysfunction has been implicated in a number of diseases including Parkinson disease. We recently demonstrated that the E3 ubiquitin ligase Parkin, which is linked to recessive fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1560eef9ee14d82b2adac57462b5b9
https://doi.org/10.4161/auto.6.8.13426
https://doi.org/10.4161/auto.6.8.13426
Publikováno v:
Pharmacological Research. 55:511-522
Recent developments in the field of protein separation allows for the analysis of qualitative and quantitative global protein changes in a particular state of a biological system. Due to the enormous number of proteins potentially present in a cell,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7149e25e456664b13d6fcd6ff4498a0a
https://doi.org/10.1016/j.phrs.2007.04.012
https://doi.org/10.1016/j.phrs.2007.04.012
Publikováno v:
Analysis of Post-Translational Modifications and Proteolysis in Neuroscience ISBN: 9781493934706
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da3bce755931607e7df8e7349e3bce89
https://doi.org/10.1007/7657_2015_85
https://doi.org/10.1007/7657_2015_85