Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Lesley A. Hill"'
1
Akademický článek
Modulatory role of prenatal alcohol exposure and adolescent stress on the response to arthritis challenge in adult female rats
Autor: Tamara S. Bodnar, David Y. Mak, Lesley A. Hill, Linda Ellis, Wayne Yu, Joanne Weinberg
Publikováno v: EBioMedicine, Vol 77, Iss , Pp 103876- (2022)
Summary: Background: There are known environmental risk factors associated with rheumatoid arthritis; however, less is known regarding how the prenatal environment impacts later-life risk for rheumatoid arthritis. Based on preliminary clinical data s
Externí odkaz: https://doaj.org/article/0d67043aa82745e799813915244dd9a6
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2
Akademický článek
N-Glycosylation influences human corticosteroid-binding globulin measurements
Autor: Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen, Geoffrey L Hammond
Publikováno v: Endocrine Connections, Vol 8, Iss 8, Pp 1136-1148 (2019)
Objective: Discrepancies in ELISA measurements of human corticosteroid-binding globulin (CBG) using detection monoclonal antibodies that recognize an epitope (9G12) within its reactive center loop (RCL), versus an epitope (12G2) in a different locati
Externí odkaz: https://doaj.org/article/b1f4b1171610499aa046afff22157cdc
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3
Multipotent stromal cells: One name, multiple identities
Autor: Hesham Soliman, Boris Hinz, Marine Theret, Wilder Scott, Tully Michael Underhill, Lesley A. Hill, Fabio M.V. Rossi
Publikováno v: Cell Stem Cell. 28:1690-1707
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and regeneration of most tissues. They can differentiate along multiple connective lineages, but unlike most other stem/progenitor cells, they carry out various other
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c320666077458af6839fc359d80652
https://doi.org/10.1016/j.stem.2021.09.001
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4
Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal Sex Differences in Rat Adrenal Development
Autor: Julia N C Toews, Tristan J Philippe, Lesley A Hill, Matthew Dordevic, Allende Miguelez-Crespo, Natalie Z M Homer, Mark Nixon, Geoffrey L Hammond, Victor Viau
Publikováno v: Endocrinology. 163
Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal to adult tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b530312147d54123b580da1e4cc7cf22
https://doi.org/10.1210/endocr/bqac152
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5
Akademický článek
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.
Autor: Jennifer L Bolton, Caroline Hayward, Nese Direk, John G Lewis, Geoffrey L Hammond, Lesley A Hill, Anna Anderson, Jennifer Huffman, James F Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H Wild, Fleur P Velders, Albert Hofman, Andre G Uitterlinden, Jari Lahti, Katri Räikkönen, Eero Kajantie, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Marika Kaakinen, Marjo-Riitta Järvelin, Nicholas J Timpson, George Davey Smith, Susan M Ring, David M Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N Anderson, Craig E Pennell, Stephen J Lye, Stephen G Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F Price, Mark W J Strachan, Rebecca M Reynolds, Henning Tiemeier, Brian R Walker, CORtisol NETwork (CORNET) Consortium
Publikováno v: PLoS Genetics, Vol 10, Iss 7, p e1004474 (2014)
Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated a
Externí odkaz: https://doaj.org/article/2b72a476ad934a7490ba2d6ab00344d3
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6
SUN-221 Subclinical Alpha-1 Antitrypsin Deficiency Is Associated with Increased Free Cortisol Fraction in Plasma and Altered Glucocorticoid Delivery to Tissues
Autor: Natalie Z.M. Homer, Lesley A Hill, Luke D Boyle, Ruth Andrew, Brian R. Walker, Geoffrey L. Hammond, Caroline Underhill, John G. Lewis, Mark Nixon, Roland H Stimson
Publikováno v: Journal of the Endocrine Society
Background Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and controls the circulating free cortisol pool. Proteolytic cleavage by neutrophil elastase is proposed to reduce CBG binding affinity and increase free cortisol availabi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590601fea823864f8883e530f422ed63
http://europepmc.org/articles/PMC7208476
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9
Roles of Plasma Binding Proteins in Modulation of Hormone Action and Metabolism
Autor: Geoffrey L. Hammond, Lesley A. Hill, Phillip Round
Steroids and thyroid hormones are transported in the blood by plasma proteins produced by the liver. These hormone-binding proteins (albumin, vitamin D-binding protein, corticosteroid-binding globulin, thyroxin-binding globulin, and sex hormone bindi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6830d0f94161fbbd48e55f1d576987c
https://doi.org/10.1016/b978-0-12-801238-3.64186-7
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10
Perinatal fluoxetine has enduring sexually differentiated effects on neurobehavioral outcomes related to social behaviors
Autor: Lesley A. Hill, Mary Gemmel, Jodi L. Pawluski, Sonsoles de Lacalle, Sophia C. Mort, Thierry Charlier
Publikováno v: Neuropharmacology
Neuropharmacology, 2019, 144, pp.70-81. ⟨10.1016/j.neuropharm.2018.10.009⟩
Neuropharmacology, Elsevier, 2019, 144, pp.70-81. ⟨10.1016/j.neuropharm.2018.10.009⟩
International audience; Selective serotonin reuptake inhibitor medications (SSRIs) are prescribed to up to 10% of pregnant women to treat maternal mood disorders. Exposure to these medications in-utero has raised concerns about altered neurobehaviora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4eb4a23361bfc80a2dcc34893e4906
https://univ-rennes.hal.science/hal-01903260
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