Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lesley A, Pearce"'
Autor:
Tashbib, Khan, Nicholas J, Lyons, Madeline, Gough, Kayden K X, Kwah, Tahleesa J, Cuda, Cameron E, Snell, Brian W, Tse, Kamil A, Sokolowski, Lesley A, Pearce, Timothy E, Adams, Stephen E, Rose, Simon, Puttick, Marina, Pajic, Mark N, Adams, Yaowu, He, John D, Hooper, Thomas, Kryza
Publikováno v:
Theranostics. 12:6915-6930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db096fd0daed377767c37a9663ed16a8
https://doi.org/10.7150/thno.78171
https://doi.org/10.7150/thno.78171
Autor:
Timothy E. Adams, Paul S. Donnelly, Rodney J. Hicks, Charlotte C. Williams, Anna Raicevic, Stacey E Rudd, Jessica Van Zuylekom, Carleen Cullinane, Lesley A. Pearce
Publikováno v:
Chemical Science
Identification of tumors which over-express Epidermal Growth Factor Receptor (EGFR) is important in selecting patients for anti-EGFR therapies. Enzymatic bioconjugation was used to introduce positron-emitting radionuclides (89Zr, 64Cu) into an anti-E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed80e4550c76940f13606408a3e2c45
http://europepmc.org/articles/PMC8261882
http://europepmc.org/articles/PMC8261882
Autor:
Charlotte C. Williams, Simon Puttick, Nicholas Lyons, Lesley A. Pearce, Lewis Perrin, Thomas Hodgkinson, Tashbib Khan, Trent P. Munro, Sinead Barry, Michael D. Lee, Timothy E. Adams, C. Blake Gilks, Thomas Kryza, Rohan Lourie, Claire M. Davies, Yaowu He, Madeline Gough, John D. Hooper, Justin B. Goh, Martina L. Jones, Rebecca Rogers, Naven Chetty
Publikováno v:
Molecular pharmaceutics. 18(9)
Optimal cytoreduction for ovarian cancer is often challenging because of aggressive tumor biology and advanced stage. It is a critical issue since the extent of residual disease after surgery is the key predictor of ovarian cancer patient survival. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d069791355b555fa3e155dcde677d3a
https://pubmed.ncbi.nlm.nih.gov/34448393
https://pubmed.ncbi.nlm.nih.gov/34448393
Autor:
Simon Puttick, Lesley A. Pearce, Michael D. Lee, Wing Yin Tong, Arghavan Golbaz-Hagh, Charlotte C. Williams, Tam Pham, Thomas Nebl, Timothy E. Adams, Stephen E. Rose
Publikováno v:
Bioconjugate Chemistry. 30:2539-2543
The functionalization of proteins with different cargo molecules is highly desirable for a broad range of applications. However, the reproducible production of defined conjugates with multiple functionalities is a significant challenge. Herein, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c875a46b4eb8c578e45bf8fed45a035
https://doi.org/10.1021/acs.bioconjchem.9b00639
https://doi.org/10.1021/acs.bioconjchem.9b00639
Autor:
Sameer A. Greenall, Harley I. Kornblum, Shengnan C Chen, Olan Dolezal, Lesley A. Pearce, Ekatarina Seminova, Mathew McKenzie, Timothy E. Adams, Terrance Grant Johns, Mani Kuchibhotla, Raelene Endersby, Kerrie L. McDonald, John D. Bentley
Publikováno v:
Neuro Oncol
Background Although epidermal growth factor receptor (EGFR) and its truncated, autoactive mutant EGFR variant (v)III are bona fide drivers of tumorigenesis in some gliomas, therapeutic antibodies developed to neutralize this axis have not improved pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969f9b5c12d29286980f5ec96410cd06
https://doi.org/10.1093/neuonc/noz073
https://doi.org/10.1093/neuonc/noz073
Autor:
Ariel Isaacs, Naphak Modhiran, James G. Barnes, Christopher L. D. McMillan, Koert J. Stittelaar, Tram Phan, Patrick C. Reading, Geert van Amerongen, Francesca L Mordant, Stacey T. M. Cheung, Connor Scott, Eve Radunz, Daniel Watterson, Louis Lu, Alberto A. Amarilla, Lukasz Kowalczyk, Mai Tran, Mallory Daleris, David A. Brockman, Marianne Gillard, Sherry J. Morgan, Zheyi Li, Noushin Jaberolansar, Julia Lackenby, Michael S. Avumegah, David Edwards, Kym Hoger, Karen Hughes, Judith A. Scoble, Charani Ranasinghe, Qi Zhou, Danushka K. Wijesundara, Fernando Villalon Letelier, Martina L. Jones, Ben Hughes, Kanta Subbarao, Mylinh La, Keith J. Chappell, Summa Bibby, Peter Tapley, Andrew Young, Cora Lau, Lesley A. Pearce, Tam Pham, Trent P. Munro, Paul R. Young, Alexander A. Khromykh, Justin B. Goh, Kate Guilfoyle
Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace with more than 30 candidate vaccines now in clinical evaluation. Here we describe the preclinical development of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f9211287e21428829cd16fc490c77f
https://doi.org/10.21203/rs.3.rs-68892/v1
https://doi.org/10.21203/rs.3.rs-68892/v1
Autor:
Victor A. Streltsov, Lesley A. Pearce, Meghan Hattarki, Colin L. Masters, J.N. Varghese, Rebecca M. Nisbet, Natalia Davydova, Remy Robert, Joanne M. Caine, Stewart N Nuttall, Olan Dolezal
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:1748-1758
Alzheimer's disease is the most common form of dementia in humans and is related to the accumulation of the amyloid-β (Aβ) peptide and its interaction with metals (Cu, Fe, and Zn) in the brain. Crystallographic structural information about Aβ pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f31ce65b1053d67d8bf547c737f73fa
https://doi.org/10.1002/prot.24312
https://doi.org/10.1002/prot.24312
Autor:
Lesley A. Pearce, Xiaowen Xiao, Sameer A. Greenall, Nicola A. Bartone, Lindsay G. Sparrow, Leah J. Cosgrove, John D. Bentley, Robert C. Baxter, Timothy E. Adams, Judith A. Scoble
Publikováno v:
Journal of Biological Chemistry. 288:59-68
Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I. Its expression in humans is tightly controlled by maternal imprinting, a genetic restraint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb2553b356f82071086be18f87a3982
https://doi.org/10.1074/jbc.m112.432013
https://doi.org/10.1074/jbc.m112.432013
Publikováno v:
Protein Science. 19:299-308
Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Abeta peptide (39-43 amino acids) derived from the proteolytic cleavage of the amyloid precursor protein is one of the main constituents of amyloid pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260238bfbba489ea91ce496fc07132d2
https://doi.org/10.1002/pro.312
https://doi.org/10.1002/pro.312
Autor:
Meghan Hattarki, Luisa Pontes-Braz, Olan Dolezal, Ralf J. Hosse, Stewart D. Nuttall, Lesley A. Pearce, Leigh Tay
Publikováno v:
Analytical Biochemistry. 385:346-357
Antibody generation by phage display and related in vitro display technologies routinely yields large panels of clones detected in primary end-point screenings such as enzyme-linked immunosorbent assay (ELISA). However, for the development of clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8eb547476d827ba8c8b49f6fa7fc5d4
https://doi.org/10.1016/j.ab.2008.11.026
https://doi.org/10.1016/j.ab.2008.11.026