Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Lesley, McGee"'
Autor:
Cebile Lekhuleni, Kedibone Ndlangisa, Rebecca A. Gladstone, Sopio Chochua, Benjamin J. Metcalf, Yuan Li, Jackie Kleynhans, Linda de Gouveia, Scott Hazelhurst, Ana D. S. Ferreira, Happy Skosana, Sibongile Walaza, Vanessa Quan, Susan Meiring, Paulina A. Hawkins, Lesley McGee, Stephen D. Bentley, Cheryl Cohen, Stephanie W. Lo, Anne von Gottberg, Mignon du Plessis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Invasive pneumococcal disease (IPD) due to non-vaccine serotypes after the introduction of pneumococcal conjugate vaccines (PCV) remains a global concern. This study used pathogen genomics to evaluate changes in invasive pneumococcal lineage
Externí odkaz:
https://doaj.org/article/428323113fd04185bfd8dcf4843186a7
Autor:
Xueting Qiu, Lesley McGee, Laura L Hammitt, Lindsay R. Grant, Katherine L. O’Brien, William P. Hanage, Marc Lipsitch
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT After introducing pneumococcal conjugate vaccines (PCVs), serotype replacement occurred in Streptococcus pneumoniae. Predicting which pneumococcal strains will become common in carriage after vaccination can enhance vaccine design, public he
Externí odkaz:
https://doaj.org/article/e21b2fdcb52c46b4aaddb515700cc6a8
Autor:
Yvette Unoarumhi, Morgan L. Davis, Lori A. Rowe, Saundra Mathis, Zhongya Li, Sopio Chochua, Yuan Li, Lesley McGee, Benjamin J. Metcalf, Justin S. Lee, Bernard Beall
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Group A streptococcal strains potentially acquire new M protein gene types through genetic recombination (emm switching). To detect such variants, we screened 12,596 invasive GAS genomes for strains of differing emm types that shared the sam
Externí odkaz:
https://doaj.org/article/7970d727ab21431580305f89bac2fe3e
Autor:
Yuan Li, Joy Rivers, Saundra Mathis, Zhongya Li, Sopio Chochua, Benjamin J. Metcalf, Bernard Beall, Jennifer Onukwube, Christopher J. Gregory, Lesley McGee
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 10, Pp 2116-2120 (2023)
From 2015–2018 to 2019‒2021, hypertoxigenic M1UK lineage among invasive group A Streptococcus increased in the United States (1.7%, 21/1,230 to 11%, 65/603; p
Externí odkaz:
https://doaj.org/article/13098321002042c1aa98d5325af4de76
Autor:
Mienye Bob-Manuel, Lesley McGee, Jeremiah A Igunma, Mary A Alex-Wele, Orikomaba K Obunge, Kennedy T Wariso
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-6 (2021)
Abstract Background Streptococcus agalactiae (Group B Streptococcus, GBS) is one of the major bacterial pathogens responsible for neonatal sepsis. Whole genome sequencing has, in recent years, emerged as a reliable tool for capsular typing and antimi
Externí odkaz:
https://doaj.org/article/bb74d5e7ed1e4e6b8c2b803c988b65b9
Autor:
Musa Mohammed Ali, Yimtubezinash Woldeamanuel, Daniel Asrat, Demissie Assegu Fenta, Bernard Beall, Stephanie Schrag, Lesley McGee
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Streptococcus agalactiae (Group B Streptococcus, GBS) serotypes, sequence types, and antimicrobial resistance profile vary across different geographic locations affecting disease patterns in newborns. These differences are importa
Externí odkaz:
https://doaj.org/article/c49939d513d74c6dac4170eb4b980de1
Autor:
Chrispin Chaguza, Madikay Senghore, Ebrima Bojang, Rebecca A. Gladstone, Stephanie W. Lo, Peggy-Estelle Tientcheu, Rowan E. Bancroft, Archibald Worwui, Ebenezer Foster-Nyarko, Fatima Ceesay, Catherine Okoi, Lesley McGee, Keith P. Klugman, Robert F. Breiman, Michael R. Barer, Richard A. Adegbola, Martin Antonio, Stephen D. Bentley, Brenda A. Kwambana-Adams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleo
Externí odkaz:
https://doaj.org/article/0e98e6e6394d47f4b1f34dfd27a30caf
Autor:
Joshua C D'Aeth, Mark PG van der Linden, Lesley McGee, Herminia de Lencastre, Paul Turner, Jae-Hoon Song, Stephanie W Lo, Rebecca A Gladstone, Raquel Sá-Leão, Kwan Soo Ko, William P Hanage, Robert F Breiman, Bernard Beall, Stephen D Bentley, Nicholas J Croucher, The GPS Consortium
Publikováno v:
eLife, Vol 10 (2021)
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resi
Externí odkaz:
https://doaj.org/article/72ee08bedd544a80947d2d1d6c45f963
Autor:
Sopio Chochua, Joy Rivers, Saundra Mathis, Zhongya Li, Srinivasan Velusamy, Lesley McGee, Chris Van Beneden, Yuan Li, Benjamin J. Metcalf, Bernard Beall
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 8, Pp 1543-1547 (2019)
The term group A Streptococcus is considered synonymous for the species Streptococcus pyogenes. We describe an emergent invasive S. dysgalactiae subspecies equisimilis lineage that obtained the group A antigen through a single ancestral recombination
Externí odkaz:
https://doaj.org/article/75eba97c08344d50b46bd566ef422bcc
Autor:
Rebecca A. Gladstone, Stephanie W. Lo, John A. Lees, Nicholas J. Croucher, Andries J. van Tonder, Jukka Corander, Andrew J. Page, Pekka Marttinen, Leon J. Bentley, Theresa J. Ochoa, Pak Leung Ho, Mignon du Plessis, Jennifer E. Cornick, Brenda Kwambana-Adams, Rachel Benisty, Susan A. Nzenze, Shabir A. Madhi, Paulina A. Hawkins, Dean B. Everett, Martin Antonio, Ron Dagan, Keith P. Klugman, Anne von Gottberg, Lesley McGee, Robert F. Breiman, Stephen D. Bentley
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 338-346 (2019)
Background: Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern. We used whole genome sequencing to study pneumococcal serotype, antibiot
Externí odkaz:
https://doaj.org/article/4f78456e71ec429c89ae26a2c712815f