Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leslee Sprague"'
Autor:
Leslee Sprague, Joel M. Lee, Brian J. Hutzen, Pin-Yi Wang, Chun-Yu Chen, Joe Conner, Lynne Braidwood, Kevin A. Cassady, Timothy P. Cripe
Publikováno v:
Viruses, Vol 10, Iss 3, p 132 (2018)
High Mobility Group Box 1 (HMGB1) is a multifunctional protein that plays various roles in the processes of inflammation, cancer, and other diseases. Many reports document abundant HMGB1 release following infection with oncolytic viruses (OVs). Furth
Externí odkaz:
https://doaj.org/article/49d4150dad95436fb37a92c1e24c853e
Autor:
Ross L. Levine, Edward M. Behrens, Leslee Sprague, Peng Guan, Makoto Kurachi, E. John Wherry, Scott W. Canna, Rupali Das, Qi Angel An, Paige Tedrick, Kim E. Nichols, Katherine Verbist, Cheng Cheng
Publikováno v:
Blood. 127:1666-1675
Hemophagocytic lymphohistiocytosis (HLH) comprises an emerging spectrum of inherited and noninherited disorders of the immune system characterized by the excessive production of cytokines, including interferon-γ and interleukins 2, 6, and 10 (IL-2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1e57ecc59bde7a843b4d6833e15397
https://doi.org/10.1182/blood-2015-12-684399
https://doi.org/10.1182/blood-2015-12-684399
Autor:
Lynne Braidwood, Joe Conner, Kevin A. Cassady, Timothy P. Cripe, Fabian Benencia, Leslee Sprague
Publikováno v:
Future virology. 13(9)
Oncolytic viruses (OVs) do more than simply infect and kill host cells. The accepted mechanism of action for OVs consists of a primary lytic phase and a subsequent antitumor and antiviral immune response. However, not all cells are subject to the dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3765f724514dc8dca589df85b863db2
https://pubmed.ncbi.nlm.nih.gov/30416535
https://pubmed.ncbi.nlm.nih.gov/30416535
Autor:
Joel M. Lee, Brian Hutzen, Chun-Yu Chen, Lynne Braidwood, Pin-Yi Wang, Joe Conner, Timothy P. Cripe, Leslee Sprague, Kevin A. Cassady
Publikováno v:
Viruses
Viruses; Volume 10; Issue 3; Pages: 132
Viruses, Vol 10, Iss 3, p 132 (2018)
Viruses; Volume 10; Issue 3; Pages: 132
Viruses, Vol 10, Iss 3, p 132 (2018)
High Mobility Group Box 1 (HMGB1) is a multifunctional protein that plays various roles in the processes of inflammation, cancer, and other diseases. Many reports document abundant HMGB1 release following infection with oncolytic viruses (OVs). Furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0d7b0c30170fbb71baa2d560ba787c
https://pubmed.ncbi.nlm.nih.gov/29543735
https://pubmed.ncbi.nlm.nih.gov/29543735
Autor:
Maria C. Courreges, Fabian Benencia, John McGinty, Michelle Pate, Kristen Mansfield, Venktesh S. Shirure, Maria Muccioli, Leslee Sprague, Jacob Osterbur, Yihan Li, Yandi Li
Publikováno v:
Immunobiology. 218:64-75
Dendritic cells (DCs) are antigen presenting cells capable of inducing specific immune responses against microbial infections, transplant antigens, or tumors. DCs have been shown to possess a high plasticity showing different phenotypes in response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae443bafc10773ca39560cca082a70c
https://doi.org/10.1016/j.imbio.2012.02.003
https://doi.org/10.1016/j.imbio.2012.02.003
Publikováno v:
ISRN Oncology
Ovarian cancer (OC) is an aggressive disease that affects approximately 1 in 70 women and has a poor prognosis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66f14ff31d8c4a121eff01e17e2c4b4
https://doi.org/10.5402/2012/642141
https://doi.org/10.5402/2012/642141
Autor:
Meghan Franczek, Leslee Sprague, Joe Conner, Nancy Ratner, Tilat A. Rizvi, Jeffrey Ecsedy, Mark A. Currier, Brian Hutzen, Brooke Nartker, Timothy P. Cripe, Pin-Yi Wang, Chun-Yu Chen
Publikováno v:
Molecular Therapy. 24:S263-S264
Aurora A Kinase (AURKA) inhibition with the investigational agent alisertib results in abnormal mitotic progression and the induction of apoptosis in multiple tumor cell lines. Cell cycle arrest is a strategy employed by a variety of viruses, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a82d0c28f764ed3e0280e657498387f
https://doi.org/10.1016/s1525-0016(16)33474-8
https://doi.org/10.1016/s1525-0016(16)33474-8
Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination
Publikováno v:
Journal of Biomedicine and Biotechnology, Vol 2012 (2012)
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology
Many clinical trials have been carried out or are in progress to assess the therapeutic potential of dendritic-cell- (DC-) based vaccines on cancer patients, and recently the first DC-based vaccine for human cancer was approved by the FDA. Herewith,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af90702fa83973c39535cb69639788cd
https://doaj.org/article/1cdc0acaec48435088c5ddc524b65575
https://doaj.org/article/1cdc0acaec48435088c5ddc524b65575
Autor:
Elizabeth Streaker, Kari Kendra, William E. Carson, Volodymr Karpa, Thomas Olencki, Anissa Bingman, Susan Geyer, Taylor R. Brooks, Kala M. Levine, Leslee Sprague, Joseph Markowitz, Sara E. Martin del Campo
Publikováno v:
Journal of Clinical Oncology. 33:e20035-e20035
e20035 Background: High dose interferon-alpha-2b (IFNa) is the only approved adjuvant therapy after surgery for high-risk melanoma lesions. The side-effects of standard year-long, high dose IFNa th...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6adefc0ddfe67bf312390f44ff9a743
https://doi.org/10.1200/jco.2015.33.15_suppl.e20035
https://doi.org/10.1200/jco.2015.33.15_suppl.e20035
Autor:
Maria Muccioli, Maria C. Courreges, Michelle Pate, Fabian Benencia, John McGinty, Kristen Mansfield, Andrew Rutowski, Omowaleola Omosebi, Harika Nandigam, Evan Meles, Amritha K. Venkatesh, Ming-yu Gu, Leslee Sprague
Publikováno v:
BMC Immunology
BMC Immunology, Vol 12, Iss 1, p 35 (2011)
BMC Immunology, Vol 12, Iss 1, p 35 (2011)
Background Dendritic cells (DCs) are antigen presenting cells capable of inducing specific immune responses against microbial infections, transplant antigens, or tumors. Interestingly, microenvironment conditions such as those present in tumor settin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c483a08d30a885005ca70def29cf411