Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Leslayann C Schecterson"'
Autor:
Jesse C Wiley, James S Meabon, Harald Frankowski, Elise A Smith, Leslayann C Schecterson, Mark Bothwell, Warren C Ladiges
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9135 (2010)
BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer'
Externí odkaz:
https://doaj.org/article/93fef6035ed349bf90e598ff0b771e94
Publikováno v:
Am J Physiol Heart Circ Physiol
Excessive vascular permeability occurs in inflammatory disease processes. Vascular endothelial cadherin (VE-cadherin) is an adhesion protein that controls vascular permeability. We identified monoclonal antibodies (mAbs) to human VE-cadherin that act
Publikováno v:
Proc Natl Acad Sci U S A
E-cadherin is a tumor suppressor protein, and the loss of its expression in association with the epithelial mesenchymal transition (EMT) occurs frequently during tumor metastasis. However, many metastases continue to express E-cadherin, and a full EM
Publikováno v:
Tissue Barriers
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Deficits in gastrointestinal (GI) paracellular permeability has been implicated in etiology of Inflammatory Bowel Disease (IBD), and E-cadherin, a key component of the epithelial junctional complex, has been implicated in both barrier function and IB
Publikováno v:
The Journal of Neuroscience. 38:6445-6460
A global loss of the fragile X mental retardation protein (FMRP; encoded by the Fmr1 gene) leads to sensory dysfunction and intellectual disabilities. One underlying mechanism of these phenotypes is structural and functional deficits in synapses. Her
Publikováno v:
Molecular Biology of the Cell
Loss of E-cadherin expression often occurs in tumors, but many metastases retain E-cadherin. Regulation of the adhesive activity of E-cadherin at the cell surface is important for metastasis of mammary tumor cells, and cancer-associated missense muta
Publikováno v:
Gastroenterology. 158:S47
Autor:
David Huss, Jason Tait Sanchez, Armin H. Seidl, Edwin W. Rubel, Scott E. Fraser, Kathryn M. Tabor, Rusty Lansford, Daniel T. Kashima, Leslayann C. Schecterson, Yuan Wang, Greg Poynter
Publikováno v:
Journal of Comparative Neurology. 521:5-23
Research performed on transgenic animals has led to numerous advances in biological research. However, using traditional retroviral methods to generate transgenic avian research models has proved problematic. As a result, experiments aimed at genetic
The chick embryo (Gallus domesticus) is one of the most important model systems in vertebrate developmental biology. The development and function of its auditory brainstem circuitry is exceptionally well studied. These circuits represent an excellent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4dc966ea3c5503d465250cbb52c6fa
https://europepmc.org/articles/PMC3495173/
https://europepmc.org/articles/PMC3495173/
Publikováno v:
Hearing Research. 73:46-56
Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are synthesized by inner and outer hair cells of the developing organ of Corti. This raises the possibility that the reorganization of cochlear innervation patterns that occurs postna