Physiologically based pharmacokinetics is impacting drug development and regulatory decision making

Autor: Rowland, Malcolm, Lesko, L, Rostami-Hochaghan, Amin

Publikováno v: Rowland, M, Lesko, L & Rostami-Hochaghan, A 2015, ' Physiologically based pharmacokinetics is impacting drug development and regulatory decision making. ', CPT: Pharmacometrics and Systems Pharmacology, vol. 4, no. 6, pp. 313-315 . https://doi.org/10.1002/psp4.52

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::020fc9271a4ea872bbacd42f8955a370
https://doi.org/10.1002/psp4.52

Towards population-specific pharmacogenomics in the era of next-generation sequencing.

Autor: Ji X; The Center for Bioinformatics and Computational Biology, The Institute of Biomedical Sciences and School of Life Sciences, School of Statistics, East China Normal University, Shanghai 200241, China; Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Ning B; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA., Liu J; Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Roberts R; ApconiX, BioHub at Alderley Park, Alderley Edge SK10 4TG, UK; University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Lesko L; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA; Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, University of Florida at Lake Nona, Orlando, FL, USA., Tong W; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. Electronic address: weida.tong@fda.hhs.gov., Liu Z; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. Electronic address: zhichao.liu@fda.hhs.gov., Shi T; The Center for Bioinformatics and Computational Biology, The Institute of Biomedical Sciences and School of Life Sciences, School of Statistics, East China Normal University, Shanghai 200241, China; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA; National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: tlshi@bio.ecnu.edu.cn.

Publikováno v: Drug discovery today [Drug Discov Today] 2021 Aug; Vol. 26 (8), pp. 1776-1783. Date of Electronic Publication: 2021 Apr 20.

A Prayer to Horus Praising Edfu.

Autor: Gabler, Kathrin¹ (AUTHOR) kgabler@uni-mainz.de

Publikováno v: Zeitschrift für Ägyptische Sprache und Altertumskunde. Nov2024, Vol. 151 Issue 2, p232-240. 9p.

ПРИЛОЖЕНИЕ НА ХРОНОФАРМАКОЛОГИЯТА ПРИ ПАЦИЕНТИ С АНКИЛОЛИЗИРАЩ СПОНДИЛОАРТРИТ.

Autor: Андреева, Лада¹ landreeva@uni-ruse.bg, Тодоров, Анна² anna.todorova@mu-varna.bg

Publikováno v: Management & Education / Upravlenie i Obrazovanie. 2024, Vol. 20 Issue 6, p30-34. 5p.

Impact of variability of in silico and in vitro octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations.

Autor: Koichiro Adachi¹, Tsubasa Sasaki¹, Atsuo Arai¹, Makiko Shimizu¹, Hiroshi Yamazaki¹ hyamazak@ac.shoyaku.ac.jp

Publikováno v: Journal of Toxicological Sciences. 2024, Vol. 49 Issue 10, p459-466. 8p.