Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Lesetja J, Legoabe"'
Autor:
Phelelisiwe S. Dube, Dylan Hart, Lesetja J. Legoabe, Audrey Jordaan, Digby F. Warner, Richard M. Beteck
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1793 (2024)
Nitrothiazole derivatives have been reported to exhibit activity against aerobic, anaerobic, and microaerophilic bacteria. This activity profile makes the nitrothiazole compound class an ideal lead source against Mycobacterium tuberculosis, which flo
Externí odkaz:
https://doaj.org/article/40c7ba286eb94060a2d26e116b07e4f3
Autor:
Phelelisiwe S. Dube, Klaudia T. Angula, Lesetja J. Legoabe, Audrey Jordaan, Jan M. Boitz Zarella, Digby F. Warner, J. Stone Doggett, Richard M. Beteck
Publikováno v:
ACS Omega. 8:17086-17102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05681ded7546c5496bb8f8756d87a150
https://doi.org/10.1021/acsomega.3c01406
https://doi.org/10.1021/acsomega.3c01406
Autor:
Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach
Publikováno v:
Molecules, Vol 26, Iss 15, p 4599 (2021)
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from Acacia auriculiformis stem bark. Column chromatography and NMR spectroscopy were used to purify and characterize betulin from an ethyl acetate solu
Externí odkaz:
https://doaj.org/article/9295c343341346118dee5825aec12a1a
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 461 (2021)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a curable airborne disease currently treated using a drug regimen consisting of four drugs. Global TB control has been a persistent challenge for many decades due to the emergence of d
Externí odkaz:
https://doaj.org/article/5ba1016889da4c9c9b8e7d15d7562513
Publikováno v:
Medicinal Chemistry Research. 31:1277-1297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78cf97ddd0af0cbd1778b5e36b9e58e
https://doi.org/10.1007/s00044-022-02908-9
https://doi.org/10.1007/s00044-022-02908-9
Autor:
Omobolanle Janet Jesumoroti, Richard M. Beteck, Audrey Jordaan, Digby F. Warner, Lesetja J. Legoabe
Publikováno v:
Molecular Diversity. 27:753-765
Tuberculosis (TB) is one of the leading causes of death worldwide. Developing new anti-TB compounds using cost-effective processes is critical to reduce TB incidence and accomplish the End TB Strategy milestone. Herein, we describe the synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979d5fb0a97bd24b7cf85e76d9747180
https://doi.org/10.1007/s11030-022-10453-1
https://doi.org/10.1007/s11030-022-10453-1
Autor:
Chrisna Matthee, Gisella Terre’Blanche, Helena D. Janse van Rensburg, Janine Aucamp, Lesetja J. Legoabe
Publikováno v:
Chemical Biology & Drug Design. 99:416-437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::919f1c23ce4841e506edb7faa026856b
https://doi.org/10.1111/cbdd.13999
https://doi.org/10.1111/cbdd.13999
Publikováno v:
Molecules, Vol 25, Iss 21, p 5182 (2020)
Malaria control relies heavily on the small number of existing antimalarial drugs. However, recurring antimalarial drug resistance necessitates the continual generation of new antimalarial drugs with novel modes of action. In order to shift the focus
Externí odkaz:
https://doaj.org/article/1e14aa8efcd54fc0ae5e2211c4e0a056
Autor:
Nadia Janse van Vuuren, Lesetja J. Legoabe, Helena D. Janse van Rensburg, Gisella Terre’Blanche
Publikováno v:
Molecular Diversity. 26:2211-2220
In a pilot study, eleven pyrrolopyridine and pyrrolopyrimidine derivatives (specifically, 7-azaindole and 7-deazapurine derivatives) were synthesised by Suzuki cross-coupling reactions and evaluated via radioligand binding assays as potential adenosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1023c0073211a314bc705da1c1e2d848
https://doi.org/10.1007/s11030-021-10327-y
https://doi.org/10.1007/s11030-021-10327-y
Publikováno v:
Molecular Diversity. 26:1779-1821
Adenosine receptors (ARs) are ubiquitously distributed throughout the mammalian body where they are involved in an extensive list of physiological and pathological processes that scientists have only begun to decipher. Resultantly, AR agonists and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117d589f6bee92c9668a5281aaf1e584
https://doi.org/10.1007/s11030-021-10257-9
https://doi.org/10.1007/s11030-021-10257-9