Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Lesa R. Gilbert"'
1
Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women
Autor: Dwight E. Matthews, Jesse F. Gregory, Yvonne Lamers, Christine Keeling, Lesa R. Gilbert, Peter W. Stacpoole, Bruce O'Rourke
Publikováno v: The American Journal of Clinical Nutrition. 90:336-343
Background: Glutathione plays various protective roles in the human body. Vitamin B-6 as pyridoxal-5′-phosphate (PLP) is required as the coenzyme in the formation of glutathione precursors. Despite this obligatory role of PLP, previous studies from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07f3d2145d777d7850463d53880b208
https://doi.org/10.3945/ajcn.2009.27747
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2
Production of 1-Carbon Units from Glycine Is Extensive in Healthy Men and Women
Autor: Christine Keeling, Jesse F. Gregory, Peter W. Stacpoole, Douglas W. Theriaque, Jerry Williamson, Yvonne Lamers, Lesa R. Gilbert, Jonathan J. Shuster
Publikováno v: The Journal of Nutrition. 139:666-671
Glycine undergoes decarboxylation in the glycine cleavage system (GCS) to yield CO(2), NH(3), and a 1-carbon unit. CO(2) also can be generated from the 2-carbon of glycine by 10-formyltetrahydrofolate-dehydrogenase and, after glycine-to-serine conver
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97f2d739b09502a42aee74c0624df1a
https://doi.org/10.3945/jn.108.103580
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3
Evaluation of Long-term Treatment of Children With Congenital Lactic Acidosis With Dichloroacetate
Autor: Paul R. Carney, Jonathan J. Shuster, Edward Valenstein, Richard E. Neiberger, Douglas W. Theriaque, Peter W. Stacpoole, Lesa R. Gilbert
Publikováno v: Pediatrics. 121:e1223-e1228
Dichloroacetate has been administered for several years to children and adults with genetic mitochondrial diseases. The primary rationale for its use is its ability to stimulate the activity of the pyruvate dehydrogenase complex, thereby facilitating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74530c3c2207ce107cfe24175f5f906
https://doi.org/10.1542/peds.2007-2062
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4
Glycine Turnover and Decarboxylation Rate Quantified in Healthy Men and Women Using Primed, Constant Infusions of [1,2-13C2]Glycine and [2H3]Leucine
Autor: Jesse F. Gregory, Yvonne Lamers, Lesa R. Gilbert, Jerry Williamson, Peter W. Stacpoole
Publikováno v: The Journal of Nutrition. 137:2647-2652
Glycine plays several roles in human metabolism, e.g. as a 1-carbon donor, in purine synthesis, and as a component of glutathione. Glycine is decarboxylated via the glycine cleavage system (GCS) that yields concurrent generation of a 1-carbon unit as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac96ad7e745cf07be99e137ea0d36766
https://doi.org/10.1093/jn/137.12.2647
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