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Akademický článek

The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.

Autor: Duncan M Gascoyne, Hayley Spearman, Linden Lyne, Rathi Puliyadi, Marta Perez-Alcantara, Les Coulton, Simon E Fisher, Peter I Croucher, Alison H Banham

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128513 (2015)

Mutations of the forkhead transcription factor FOXP2 gene have been implicated in inherited speech-and-language disorders, and specific Foxp2 expression patterns in neuronal populations and neuronal phenotypes arising from Foxp2 disruption have been

Externí odkaz: https://doaj.org/article/e960b1051d604d118b097524efe614b3

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Akademický článek

Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone.

Autor: Giorgio Giacomo Galli, Kristian Honnens de Lichtenberg, Matteo Carrara, Wolfgang Hans, Manuela Wuelling, Bettina Mentz, Hinke Arnolda Multhaupt, Cathrine Kolster Fog, Klaus Thorleif Jensen, Juri Rappsilber, Andrea Vortkamp, Les Coulton, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Raffaele Adolfo Calogero, John Robert Couchman, Anders Henrik Lund

Publikováno v: PLoS Genetics, Vol 8, Iss 5, p e1002711 (2012)

PRDM family members are transcriptional regulators involved in tissue specific differentiation. PRDM5 has been reported to predominantly repress transcription, but a characterization of its molecular functions in a relevant biological context is lack

Externí odkaz: https://doaj.org/article/806cc67a9a3f48ab931ab041b14e495d

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Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival

Autor: Eline Menu, Hendrik De Raeve, Karin Vanderkerken, Evy De Leenheer, Kenneth Nilsson, Les Coulton, Olle Larsson, Magnus Axelson, Orla Gallagher, Peter I. Croucher, Ben Van Camp, Helena Jernberg-Wiklund, Els Van Valckenborgh

Publikováno v: Vrije Universiteit Brussel

During the last decade, a central role for insulin-like growth factor 1 (IGF-1) in the pathophysiology of multiple myeloma (MM) has been well established. IGF-I provided by the tumor-microenvironment interaction may directly and indirectly facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf145436cd167e3b67db3917cc660a6c
https://doi.org/10.1002/ijc.22845

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Effect of 50 Hz Electromagnetic Fields on the Induction of Heat-Shock Protein Gene Expression in Human Leukocytes

Autor: Les Coulton, A. Graham Pockley, Paul A. Harris, Anthony T. Barker

Publikováno v: Radiation Research. 161:430-434

Although evidence is controversial, exposure to environmental power-frequency magnetic fields is of public concern. Cells respond to some abnormal physiological conditions by producing cytoprotective heat-shock (or stress) proteins. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13579b67b8990be6791c95ddbbc12a68
https://doi.org/10.1667/rr3145

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Alendronate in the treatment of Paget's disease of bone

Autor: S. Rogers, J. Orgee, Monique N.C. Beneton, Eugene V. McCloskey, Samuel D Vasikaran, G. Coombes, S. Khan, Les Coulton, John A. Kanis

Publikováno v: Bone. 20:263-271

We studied four treatment regimens of oral alendronate in 60 patients with active Paget's disease. Two groups received an oral daily dose of either 40 or 80 mg of alendronate for 3 months, followed by placebo for a further 3 months: the other two gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351449727c61d244819445882258b5ef
https://doi.org/10.1016/s8756-3282(96)00364-x

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Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone

Autor: Manuela Wuelling, Anders H. Lund, Bettina Mentz, Cathrine K. Fog, Helmut Fuchs, Hinke A.B. Multhaupt, Matteo Carrara, Andrea Vortkamp, Wolfgang Hans, Raffaele A. Calogero, Martin Hrabě de Angelis, Klaus T. Jensen, Giorgio G. Galli, Juri Rappsilber, John R. Couchman, Kristian Honnens de Lichtenberg, Les Coulton, Valerie Gailus-Durner

Publikováno v: Galli, G G, Honnens de Lichtenberg, K, Mentz, B, Fog, C K, Jensen, K T, Lund, A H, Carrara, M, Calogero, R A, Hans, W, Gailus-Durner, V, Hrabě de Angelis, M, Wuelling, M, Vortkamp, A, Fuchs, H, Multhaupt, H A, Couchman, J R, Rappsilber, J & Coulton, L 2012, ' Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone ', PLoS Genetics, vol. 8, no. 5 . https://doi.org/10.1371/journal.pgen.1002711
PLoS Genet. 8:e1002711 (2012)
PLoS Genetics, Vol 8, Iss 5, p e1002711 (2012)
PLoS Genetics
PLoS Genetics; Vol 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1696538a5871c6c894f058915a450033
https://hdl.handle.net/20.500.11820/16f8edaa-c18e-4ec5-8c2f-fc6a0efdc56c

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The effect of tibial lengthening on immature articular cartilage of the ankle joint

Autor: Gang Cai, Michael Saleh, Les Coulton, Lang Yang

Publikováno v: Journal of pediatric orthopedics. Part B. 19(5)

Is the articular cartilage of the immature ankle joint damaged by tibial lengthening? Sixteen immature rabbits underwent a 30% diaphyseal lengthening by tibial callotasis. Damage was assessed by scanning electronic microscopy and histomorphometry at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4373af3f6827d34c10c0e7899968c1f9
https://pubmed.ncbi.nlm.nih.gov/20389258

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Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo

Autor: Karin Vanderkerken, Timothy R. Arnett, Debby Heath, Peter I. Croucher, Mary L. Bouxsein, Michelle L. Key, Les Coulton, Eric D. Werner, Scott Pearsall, Andrew D Chantry, Nicole Abdul, Aaron W. Mulivor, Holly Evans, Jasbir Seehra, Marc Baud’huin

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 25(12)

Cancers that grow in bone, such as myeloma and breast cancer metastases, cause devastating osteolytic bone destruction. These cancers hijack bone remodeling by stimulating osteoclastic bone resorption and suppressing bone formation. Currently, treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe5d76d36dc63a92b19622b5305af54
https://pubmed.ncbi.nlm.nih.gov/20533325

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Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma

Autor: Clive Buckle, Holly Evans, Deborah J. Heath, John D. Shaughnessy, David R. Stover, Les Coulton, Peter I. Croucher, Karin Vanderkerken, John A. Snowden, Andrew D Chantry

Publikováno v: Vrije Universiteit Brussel

Multiple myeloma (MM) is associated with the development of osteolytic bone disease, mediated by increased osteoclastic bone resorption and impaired osteoblastic bone formation. Dickkopf-1 (Dkk1), a soluble inhibitor of wingless/int (Wnt) signaling a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d292594c640855652ed9a0110aa9ba
https://hdl.handle.net/20.500.14017/f0bfb978-dc99-49e9-89cf-3e54cb362b27

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A double-blind study of deflazacort and prednisone in patients with chronic inflammatory disorders

Autor: R.E.S. Gray, J. Galloway, J. A. Kanis, S. M. Doherty, M. De Broe, Les Coulton

Publikováno v: Arthritis & rheumatism

Deflazacort and prednisone were given to 26 patients with rheumatoid arthritis, polymyalgia rheumatica, or other chronic inflammatory diseases, in a double-blind study. Deflazacort rapidly and effectively suppressed disease activity in a manner suppo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c609a11f4212cefcee7e04624074a65
https://doi.org/10.1002/art.1780340306

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