Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Leroy Perkins"'
Autor:
Matthew J. Wyvratt, Leroy Perkins, Randall R. Miller, Ann E. Weber, William P. Feeney, Vincent J. Colandrea, Michael J. Forrest, Emma R. Parmee, Laurie Tota, Michael H. Fisher, Mari R. Candelore, Gary J Hom, Hyun O. Ok, Elizabeth M. Naylor, Catherine D. Strader, Margaret A. Cascieri, Ralph A. Stearns, Liping Deng, D. Euan MacIntyre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:749-754
Human beta3 adrenergic receptor agonists containing 5-membered ring ureas were shown to be potent partial agonists with excellent selectivity over beta1 and beta2 binding. L-760,087 (4a) and L-764,646 (5a) (beta3 EC50 = 18 and 14 nM, respectively) st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db42333a159b96a8041c9342edbccdfb
https://doi.org/10.1016/s0960-894x(99)00073-6
https://doi.org/10.1016/s0960-894x(99)00073-6
Autor:
Michael H. Fisher, Mari R. Candelore, Jennifer E. Hutchins, Robert J. Mathvink, Matthew J. Wyvratt, Leroy Perkins, Ann E. Weber, Laurie Tota, Catherine D. Strader
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1101-1106
A cloned human beta 3 adrenergic receptor assay was used to identify phenoxypropanolamine agonist 1. SAR studies led to the identification of benzenesulfonamide derivative 20, a 6.3 nM beta 3 agonist which shows 30-fold selectivity for beta 3 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608f43b1b7690cf1d918a3c2a3a79457
https://doi.org/10.1016/s0960-894x(98)00169-3
https://doi.org/10.1016/s0960-894x(98)00169-3
Autor:
Jennifer E. Hutchins, Michael H. Fisher, Ann E. Weber, Catherine D. Strader, Mari R. Candelore, Robert J. Mathvink, Laurie Tota, Matthew J. Wyvratt, Leroy Perkins
Publikováno v:
ChemInform. 29
A cloned human beta 3 adrenergic receptor assay was used to identify phenoxypropanolamine agonist 1. SAR studies led to the identification of benzenesulfonamide derivative 20, a 6.3 nM beta 3 agonist which shows 30-fold selectivity for beta 3 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::270e22f848d8773a26c141e3f344fa30
https://doi.org/10.1002/chin.199836136
https://doi.org/10.1002/chin.199836136
Autor:
Elizabeth M. Naylor, D. Euan MacIntyre, Liping Deng, Catherine D. Strader, Michael H. Fisher, Margaret A. Cascieri, Lawrence F. Colwell, William P. Feeney, Ann E. Weber, Pei-Ran Wang, Mari R. Candelore, Gary J Hom, Linda Brockunier, Laurie Tota, Michael J. Forrest, Vincent J. Colandrea, Emma R. Parmee, Matthew J. Wyvratt, Leroy Perkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
The cyclopentylpropylimidazolidinone L-766,892 is a potent beta3 AR agonist (EC50 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to the beta1 and beta2 ARs, respectively. In anesthetized rhesus monkeys, L-766,892 elicited dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60300a82b7c997c104412a4ce4b5d96
https://pubmed.ncbi.nlm.nih.gov/10201842
https://pubmed.ncbi.nlm.nih.gov/10201842
Autor:
Michael J. Forrest, John Kao, Michael H. Fisher, Pasquale P. Vicario, Shuet-Hing Lee Chiu, Jennifer E. Hutchins, Raul F. Alvaro, Ronald C. Newbold, Timothy V Olah, Ann E. Weber, Ralph A. Stearns, Emma R. Parmee, Yui S. Tang, John Szumiloski, D. Euan MacIntyre, Debra McLoughlin, Hyun O. Ok, Matthew J. Wyvratt, Mari R. Candelore, Gary J Hom, Leroy Perkins, Catherine D. Strader, Margaret A. Cascieri, Laurie Tota, Liping Deng, Robert J. Mathvink, Randall R. Miller
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(16)
Pyridyloxypropanolamines L-749,372 ( 8 , β 3 EC 50 = 3.6 nM) and L-750,355 ( 29 , β 3 EC 50 = 13 nM) are selective partial agonists of the human receptor, with 33% and 49% activation, respectively. Both stimulate lipolysis in rhesus monkeys (ED 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52e5f47eefa66afb40ebad30a08f9ec
https://pubmed.ncbi.nlm.nih.gov/9873496
https://pubmed.ncbi.nlm.nih.gov/9873496
Autor:
Robin Scarcella, Leroy Perkins
Publikováno v:
Studies in Second Language Acquisition. 9:347-353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ed81d88b179755a5ad0a0536818661
https://doi.org/10.1017/s0272263100006720
https://doi.org/10.1017/s0272263100006720
Publikováno v:
Chemischer Informationsdienst. Organische Chemie. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cebac5fca5271d60cc8500489641706
https://doi.org/10.1002/chin.197040006
https://doi.org/10.1002/chin.197040006
Autor:
W. LeRoy Perkins
Publikováno v:
Economic Geography. 7:380
F ROR more than three-quarters of a century the manufacture of drain tile has been a substantial industry in Indiana. From the total of 143 factories in 1904, the number has decreased to 24 at the present time. Taking into account, however, the monet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::750b3b77ce8b33790b389e9ca8196d57
https://doi.org/10.2307/140313
https://doi.org/10.2307/140313