PDE4 as a target in preterm labour

Autor: Hervé Roxane, Oger Stéphanie, Schmitz Thomas, Méhats Céline, Cabrol Dominique, Leroy Marie-Josèphe

Publikováno v: BMC Pregnancy and Childbirth, Vol 7, Iss Suppl 1, p S12 (2007)

Abstract Cyclic nucleotide phosphodiesterases (PDE) are the enzymes catalyzing the hydrolysis and inactivation of the second messengers, cAMP and cGMP. Eleven PDE families are described to date, and selective inhibitors of some PDEs families are curr

Externí odkaz: https://doaj.org/article/708dddc685a14c728fc81adf56f69d38

Role of Steroids in the Onset of Labor

Autor: Leroy Marie Josèphe, Michelle Breuiller-Fouché, Guy Germain

Publikováno v: Control of Uterine Contractility ISBN: 9780429261756
Control of Uterine Contractility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49c12be0c876c25dd8c7b077cbfa7abc
https://doi.org/10.1201/9780429261756-9

In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor

Autor: Croci, Tiziano, Cecchi, Roberto, Marini, Pietro, Rouget, Céline, Viviani, Nunzia, Germain, Guy, Guagnini, Fabio, Fradin, Yvon, Descamps, Laurence, Pascal, Marc, Advenier, Charles, Breuiller-Fouché, Michelle, Leroy, Marie-Josèphe, Bardou, Marc

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 321 (3), pp.1118-26. ⟨10.1124/jpet.106.119123⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 321 (3), pp.1118-26. 〈10.1124/jpet.106.119123〉
Journal of Pharmacology and Experimental Therapeutics, 2007, 321 (3), pp.1118-26. ⟨10.1124/jpet.106.119123⟩

International audience; Ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino] phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640) was characterized as a new potent and selective beta(3)-adrenoceptor agonist for the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::365736cea0a91c161381a8feb73de113
https://www.hal.inserm.fr/inserm-00171797/document

Surfactant protein a signaling pathways in human uterine smooth muscle cells

Autor: Garcia-Verdugo, Ignacio, Tanfin, Zahra, Dallot, Emmanuelle, Leroy, Marie-Josèphe, Breuiller-Fouché, Michelle

Publikováno v: Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2008, 79 (2), pp.348-55. ⟨10.1095/biolreprod.108.068338⟩
Biology of Reproduction, 2008, 79 (2), pp.348-55. ⟨10.1095/biolreprod.108.068338⟩
Biology of Reproduction, Society for the Study of Reproduction, 2008, 79 (2), pp.348-55. 〈10.1095/biolreprod.108.068338〉

International audience; The present study investigated the ability of surfactant associated protein A1 (SFTPA1), a major component of lung surfactant, to bind and serve as a signal in human cultured myometrial cells. By using ligand blot analysis wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64fcd90e64e518c1890ed31613d92bf1
https://www.hal.inserm.fr/inserm-00322003

PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation

Autor: Schmitz, Thomas, Souil, Evelyne, Hervé, Roxane, Nicco, Carole, Batteux, Frédéric, Germain, Guy, Cabrol, Dominique, Evain-Brion, Danièle, Leroy, Marie-Josèphe, Méhats, Céline

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 178 (2), pp.1115-21

The aim of this study was to explore the anti-inflammatory properties of phosphodiesterase-4 (PDE4) inhibitors in vivo and their potential ability to prevent inflammation-induced preterm delivery. Indeed, intrauterine inflammation is the major etiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9da934c3477d74f82a98715717e47798
https://www.hal.inserm.fr/inserm-00112464/document