Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Leroy B. Townsend"'
Autor:
Elke Bogner, Ina Woskobojnik, John C. Drach, Rebekka Adfeldt, Sebastian Voigt, Alexandra Dittmer, Leroy B. Townsend
Publikováno v:
Antiviral Research. 137:102-107
Background Benzimidazole D-ribonucleosides are potent and selective inhibitors of CMV infection that have been shown to target the viral terminase, the enzyme complex responsible for viral DNA cleavage into single unit-length genomes and subsequent D
Autor:
John C. Drach, Jeremy P. Kamil, Ellie D. Hall, Quang Phan, Brian G. Gentry, Leroy B. Townsend, Julie M. Breitenbach, Katherine Z. Borysko
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:226-232
Human cytomegalovirus (HCMV) infection can cause severe illnesses, including encephalopathy and mental retardation, in immunocompromised and immunologically immature patients. Current pharmacotherapies for treating systemic HCMV infections include ga
Autor:
John C. Drach, Karen M. Watson, Tracy L. Hartman, Leroy B. Townsend, Brian G. Gentry, Roger G. Ptak, M. Clayton Osterling, Robert W. Buckheit
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:1512-1519
Triciribine (TCN) is a tricyclic nucleoside that inhibits human immunodeficiency virus type 1 (HIV-1) replication by a unique mechanism not involving the inhibition of enzymes directly involved in viral replication. This activity requires the phospho
Publikováno v:
Phytochemistry. 70:190-197
The auxins, plant hormones, play a crucial role in many aspects of plant development by regulating cell division, elongation and differentiation. Toyocamycin, a nucleoside-type antibiotic, was identified as auxin signaling inhibitor in a screen of mi
Autor:
John C. Drach, Christopher P. Landowski, Leroy B. Townsend, Andrea Brancale, Philip L. Lorenzi, Gordon L. Amidon, Xueqin Song
Publikováno v:
Lorenzi, P L, Landowski, C P, Brancale, A, Song, X, Townsend, L B, Drach, J C & Amidon, G L 2006, ' N-methylpurine DNA glycosylase and 8-oxoguanine DNA glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(β-D-ribofuranosyl) benzimidazole ', Drug Metabolism and Disposition, vol. 34, no. 6, pp. 1070-1077 . https://doi.org/10.1124/dmd.105.009209
The rapid in vivo degradation of the potent human cytomegalovirus inhibitor 2-bromo-5,6-dichloro-1-(β-D-ribofuranosyl)benzimidazole (BDCRB) compared with a structural L-analog, maribavir (5,6-dichloro-2-(isopropylamino)-1-β- L-ribofuranosyl-1H-benz
Publikováno v:
Journal of Virology. 79:14660-14667
The process of viral DNA packaging is multifunctional and determined by specific interactions of protein-DNA and protein-protein. An important role during this process is played by portal proteins. Portals are large macromolecules and are found throu
Publikováno v:
Journal of Medicinal Chemistry. 48:3840-3851
The synthesis of several heterocyclic analogues of the biologically important nucleoside antibiotic toyocamycin and the tricyclic nucleoside triciribine (TCN) were prepared along with their 2‘-deoxy counterparts. Coupling of 2-nitropyrrole-3,4-dica
Design, Synthesis, and Antiviral Activity of Certain 3-Substituted 2,5,6-Trichloroindole Nucleosides
Publikováno v:
Journal of Medicinal Chemistry. 47:5753-5765
A series of trichlorinated indole nucleosides has been synthesized and tested for activity against human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1) and for cytotoxicity. Modifications of the previously reported 2,5,6-trichloro-1-(
Publikováno v:
Journal of Medicinal Chemistry. 47:5766-5772
A series of trichlorinated indole nucleosides has been synthesized and tested for activity against human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1) and for cytotoxicity. The previously reported 3-formyl-2,5,6-trichloro-1-(beta-D-r
Publikováno v:
Tetrahedron Letters. 45:4105-4108
1-Substituted 5-aminopyrazole-4-carbonylazides were prepared from the appropriate 5-aminopyrazole-4-carboxylates. The acyl azides undergo a Curtius rearrangement followed by quenching with alcohols to form the corresponding carbamates. The 1-substitu