Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Leroy Alexander"'
Publikováno v:
Molecules
Molecules; Volume 27; Issue 9; Pages: 2958
Molecules; Volume 27; Issue 9; Pages: 2958
Previous published data from our group showed the encouraging in vitro activities of six phenolic temozolomide (TMZ) ester analogues (ES8–ES12 and ES14) with up to a five-fold increase in potency compared to TMZ against glioblastoma multiform cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5069f8b8a6fc0c5743f721d8d5788f1
https://pubmed.ncbi.nlm.nih.gov/35566308
https://pubmed.ncbi.nlm.nih.gov/35566308
Publikováno v:
RSC Advances
The standard of care treatment for patients diagnosed with glioblastoma multiforme (GBM) is temozolomide (TMZ). Tumour resistance to TMZ results in significantly limited clinical effectiveness. There is therefore an inherent need for alternatives to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12335d2f92f35b9b13f84aa43c60378a
https://doi.org/10.1039/d0ra02686g
https://doi.org/10.1039/d0ra02686g
Autor:
Beatriz C. Pereira, Rober Habashy, Mohamed Albed Alhnan, Abdullah Isreb, Leroy Alexander Shervington, Magda Kuźmińska, Filipa Dores, Matthew Peak, Marton Bohus, Cindy Soares
On demand manufacturing of patient-specific oral doses provides significant advantages to patients and healthcare staff. Several 3D printing (3DP) technologies have been proposed as a potential digital alternative to conventional manufacturing of ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f9c986d927e14962817698410f06ba
Autor:
Leroy, Alexander María
Since cinema is visual and tells a story at the same time, it is a medium that specifically contributes to shared representations, constituting a rich source of study for the sociologist. With its huge number of productions, the diverse films made by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::8ef8402a792c3bee279d1c04d693637d
https://hal-normandie-univ.archives-ouvertes.fr/hal-02302394
https://hal-normandie-univ.archives-ouvertes.fr/hal-02302394
Publikováno v:
Journal of Cancer
Cancer inducible molecular chaperone HSP90 is of great importance as an anticancer target. Proteomic analysis showed that inhibiting HSP90 by the geldanamycin derivative, 17-AAG elevated the expression of the co-chaperone Hsp70. In this study we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47130f079b029862e6863198c8d5a29
http://europepmc.org/articles/PMC4504115
http://europepmc.org/articles/PMC4504115
Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells?
Publikováno v:
International Journal of Brain Science. 2014:1-9
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17-demethoxygel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec547698fff023505121eea6b7da9f4a
https://doi.org/10.1155/2014/652643
https://doi.org/10.1155/2014/652643
Publikováno v:
Cancer Investigation. 31:404-411
The efficacy of glioma therapy can be considerably improved if it eliminates cancer stem cells (CSCs); however, to achieve this, CSCs markers are required. This study investigated the influence of micro-environmental changes on CSCs in hypoxic, serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c15fe6b642ed26cac16225b7296872
https://doi.org/10.3109/07357907.2013.802800
https://doi.org/10.3109/07357907.2013.802800
Publikováno v:
Cancers
Cancers, Vol 3, Iss 4, Pp 4228-4244 (2011)
Volume 3
Issue 4
Pages: 4228-4244
Cancers, Vol 3, Iss 4, Pp 4228-4244 (2011)
Volume 3
Issue 4
Pages: 4228-4244
Hsp90a’s vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma. Hsp90a was downregulated using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b22164e7aade1c14f118dbd5a6b5de0
http://europepmc.org/articles/PMC3763420
http://europepmc.org/articles/PMC3763420
Autor:
Leroy Alexander Shervington, Bianca Szeaar Li, Ebrahim Mulla, Amal Shervington, Usamah Muttakin, Ronak Y. Patel, Nsima Alpan
Publikováno v:
International Journal of Chemistry. 10:28
Moringa oleifera has been used for centuries as a traditional medicine in a number of sub-tropical countries. Recent studies have found it to be rich in flavonoids that exhibit antioxidant activity both in vitro and in vivo. In this study slightly mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63f835f7b35f29f2eee4ce5969aa58a7
https://doi.org/10.5539/ijc.v10n4p28
https://doi.org/10.5539/ijc.v10n4p28