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Akademický článek

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

Autor: Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani

Publikováno v: mAbs, Vol 16, Iss 1 (2024)

Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To reach protective levels in fetuses, mAbs must be transported across the placenta, a selectiv

Externí odkaz: https://doaj.org/article/c3903556c3ab42faabeedc9cf418281c

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Akademický článek

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Akademický článek

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

Publikováno v: International Journal of Infectious Diseases, Vol 103, Iss , Pp 25-32 (2021)

Objective: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, we investigat

Externí odkaz: https://doaj.org/article/aa64df75735341c59242e660d8c57951

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Akademický článek

Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy

Autor: Xuanmao Jiao, Min Wang, Zhao Zhang, Zhiping Li, Dong Ni, Anthony W. Ashton, Hsin-Yao Tang, David W. Speicher, Richard G. Pestell

Publikováno v: Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)

Abstract Background Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled receptor CCR5 was expresse

Externí odkaz: https://doaj.org/article/41566b0001e24966bb1515ddc84ff1a7

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Akademický článek

The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis

Autor: Michael Doulberis, Kasiani Papadimitriou, Apostolis Papaefthymiou, Jannis Kountouras, Stergios A. Polyzos

Publikováno v: Exploration of Medicine, Vol 1, Iss 4, Pp 170-183 (2020)

Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity and mortality, without having to-date any licensed treatment. C

Externí odkaz: https://doaj.org/article/5982f31b3aa84ce197206cdcdb4ba383

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Akademický článek

Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab

Autor: Nicholas Agresti, Jacob P. Lalezari, Phillip P. Amodeo, Kabir Mody, Steven F. Mosher, Harish Seethamraju, Scott A. Kelly, Nader Z. Pourhassan, C. David Sudduth, Christopher Bovinet, Ahmed E. ElSharkawi, Bruce K. Patterson, Reejis Stephen, Jonah B. Sacha, Helen L. Wu, Seth A. Gross, Kush Dhody

Publikováno v: Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100083- (2021)

Coronavirus disease 2019 (COVID-19) is associated with considerable morbidity and mortality. The number of confirmed cases of infection with SARS-CoV-2, the virus causing COVID-19 continues to escalate with over 70 million confirmed cases and over 1.

Externí odkaz: https://doaj.org/article/390ffb01517147668c69e13a6b1b62e2

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Akademický článek

Case study of a critically ill person with COVID-19 on ECMO successfully treated with leronlimab

Autor: Sohier Elneil, Jacob P. Lalezari, Nader Z. Pourhassan

Publikováno v: Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100097- (2021)

The number of confirmed cases of infection with SARS-CoV-2, the virus causing Coronavirus disease 2019 (COVID-19), continues to increase and is associated with substantial morbidity and mortality in virtually every country in the world. Although in t

Externí odkaz: https://doaj.org/article/9ad17770ea7843f29ecf48025c9fe10c

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Akademický článek

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Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome

Autor: Norman B, Gaylis, Angela, Ritter, Scott A, Kelly, Nader Z, Pourhassan, Meenakshi, Tiwary, Jonah B, Sacha, Scott G, Hansen, Christopher, Recknor, Otto O, Yang

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 75, iss 7

In an exploratory trial treating “long COVID” with the CCR5-binding antibody leronlimab, we observed significantly increased blood cell surface CCR5 in treated symptomatic responders but not in nonresponders or placebo-treated participants. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b77e1c3b9455084b23ec4ff0e0666ce
https://doi.org/10.1093/cid/ciac226

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Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels

Autor: Catherine J Hutchings

Publikováno v: Antibody Therapeutics

Antibodies are now well established as therapeutics with many additional advantages over small molecules and peptides relative to their selectivity, bioavailability, half-life and effector function. Major classes of membrane-associated protein target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44536ac1254cb07dfd961edacae1cc60
https://doi.org/10.1093/abt/tbaa023

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