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Publikováno v:
BMC Bioinformatics, Vol 13, Iss 1, p 110 (2012)
Abstract Background Figures of phylogenetic trees are widely used to illustrate the result of evolutionary analyses. However, one cannot easily extract a machine-readable representation from such images. Therefore, new software emerges that helps to
Externí odkaz:
https://doaj.org/article/e7dba23532cc4733988eb655c9dcc0ee
Publikováno v:
BMC Genomics, Vol 12, Iss 1, p 320 (2011)
Abstract Background The regulatory information encoded in the DNA of promoter regions usually enforces a minimal, non-zero distance between the coding regions of neighboring genes. However, the size of this minimal regulatory space is not generally k
Externí odkaz:
https://doaj.org/article/8c9cf8b9b7db419098e0257c16ecc7d1
Publikováno v:
BMC Evolutionary Biology, Vol 10, Iss 1, p 316 (2010)
Abstract Background Many functional, structural and evolutionary features of human genes have been observed to correlate with expression breadth and/or gene age. Here, we systematically explore these correlations. Results Gene age and expression brea
Externí odkaz:
https://doaj.org/article/9397ca77afb04195be79a2bf57912663
Autor:
Wang Guang-Zhong, Lercher Martin J
Publikováno v:
BMC Evolutionary Biology, Vol 10, Iss 1, p 263 (2010)
Abstract Background Among bacteria and archaea, amino acid usage is correlated with habitat temperatures. In particular, protein surfaces in species thriving at higher temperatures appear to be enriched in amino acids that stabilize protein structure
Externí odkaz:
https://doaj.org/article/404a11b8974f424a8059fe8a59fbb4a1
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 178 (2010)
Abstract Background In all eukaryotic species examined, genes that are chromosomal neighbours are more similar in their expression than random gene pairs. Currently, it is still unclear how much of this local co-expression is caused by direct transcr
Externí odkaz:
https://doaj.org/article/ccf58d0ccd8c48cba4ebeb60708f333d
Publikováno v:
BMC Evolutionary Biology, Vol 9, Iss 1, p 193 (2009)
Abstract Background A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive ge
Externí odkaz:
https://doaj.org/article/9ef59657c2574435b6188de99881f737
Autor:
Chen Wei-Hua, Lercher Martin J
Publikováno v:
BMC Research Notes, Vol 2, Iss 1, p 155 (2009)
Abstract Background Genome sequencing projects and comparative genomics studies typically aim to trace the evolutionary history of large gene sets, often requiring human inspection of hundreds of phylogenetic trees. If trees are checked for compatibi
Externí odkaz:
https://doaj.org/article/d1169f0b74f641eab8734659a27ad771
Publikováno v:
BMC Evolutionary Biology, Vol 6, Iss 1, p 7 (2006)
Abstract Background The rate of molecular evolution varies widely between proteins, both within and among lineages. To what extent is this variation influenced by genome-wide, lineage-specific effects? To answer this question, we assess the rate vari
Externí odkaz:
https://doaj.org/article/d5461890292a4784acabf586844b33af
Autor:
Lercher Martin J, Hurst Laurence D
Publikováno v:
BMC Evolutionary Biology, Vol 5, Iss 1, p 62 (2005)
Abstract Background Prior to the sequencing of the human genome it was typically assumed that, tandem duplication aside, gene order is for the most part random. Numerous observers, however, highlighted instances in which a ligand was linked to one of
Externí odkaz:
https://doaj.org/article/68b80a73e0044d1db1dc8b9425de892c