Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.

Autor: Joncour A, Desroy N, Housseman C, Bock X, Bienvenu N, Cherel L, Labeguere V, Peixoto C, Annoot D, Lepissier L, Heiermann J, Hengeveld WJ, Pilzak G, Monjardet A, Wakselman E, Roncoroni V, Le Tallec S, Galien R, David C, Vandervoort N, Christophe T, Conrath K, Jans M, Wohlkonig A, Soror S, Steyaert J, Touitou R, Fleury D, Vercheval L, Mollat P, Triballeau N, van der Aar E, Brys R, Heckmann B

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4270. Date of Electronic Publication: 2018 Apr 19.

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.

Autor: Joncour A; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Desroy N; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Housseman C; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Bock X; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Bienvenu N; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Cherel L; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Labeguere V; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Peixoto C; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Annoot D; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Lepissier L; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Heiermann J; Mercachem , Kerkenbos 1013, 6546 Nijmegen, The Netherlands., Hengeveld WJ; Mercachem , Kerkenbos 1013, 6546 Nijmegen, The Netherlands., Pilzak G; Mercachem , Kerkenbos 1013, 6546 Nijmegen, The Netherlands., Monjardet A; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Wakselman E; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Roncoroni V; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Le Tallec S; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Galien R; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., David C; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Vandervoort N; Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Christophe T; Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Conrath K; Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Jans M; Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Wohlkonig A; VIB Structural Biology Research Center, Vrije Universiteit Brussel , 1050 Brussel, Belgium., Soror S; VIB Structural Biology Research Center, Vrije Universiteit Brussel , 1050 Brussel, Belgium., Steyaert J; VIB Structural Biology Research Center, Vrije Universiteit Brussel , 1050 Brussel, Belgium., Touitou R; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Fleury D; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Vercheval L; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Mollat P; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., Triballeau N; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France., van der Aar E; Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Brys R; Galapagos NV , Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Heckmann B; Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Sep 14; Vol. 60 (17), pp. 7371-7392. Date of Electronic Publication: 2017 Aug 18.

Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.

Autor: Joshi, Lisha¹ (AUTHOR) lisha.joshi@medunigraz.at, Plastira, Ioanna¹ (AUTHOR) ioanna.plastira@medunigraz.at, Bernhart, Eva¹ (AUTHOR) eva.bernhart@medunigraz.at, Reicher, Helga¹ (AUTHOR) helga.reicher@medunigraz.at, Triebl, Alexander² (AUTHOR) alex.triebl@gmx.at, Köfeler, Harald C.^2,3 (AUTHOR) harald.koefeler@medunigraz.at, Sattler, Wolfgang^1,3 (AUTHOR) wolfgang.sattler@medunigraz.at

Publikováno v: International Journal of Molecular Sciences. Aug2021, Vol. 22 Issue 16, p8519-8519. 1p.

The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions.

Autor: Salgado-Polo, Fernando¹ (AUTHOR) f.salgado@nki.nl, Perrakis, Anastassis¹ (AUTHOR) a.perrakis@nki.nl

Publikováno v: Cancers. Oct2019, Vol. 11 Issue 10, p1577. 1p.

Druggable Lipid Signaling Pathways

Autor: Yasuyuki Kihara

Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides,