Zobrazeno 1 - 10
of 22
pro vyhledávání: '"LepR, leptin receptor"'
Autor:
Takehito Ouchi, Taneaki Nakagawa
Publikováno v:
Regenerative Therapy, Vol 14, Iss, Pp 72-78 (2020)
Regenerative Therapy
Regenerative Therapy
Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. The current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5f25854d71411f6acf28c93a9c9486
https://doi.org/10.1016/j.reth.2019.12.011
https://doi.org/10.1016/j.reth.2019.12.011
Autor:
Claudia Berger, Matthias Blüher, Janet Kelso, Nora Klöting, Henrike O. Heyne, Esther Guiu-Jurado, Tina Heiland, Peter Kovacs, Sebastian Dommel, Steffen Roßner, Michael Dannemann, Corinna Höfling, Jana Lorenz
Publikováno v:
Journal of Lipid Research
J. Lipid Res. 62:100105 (2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100105-(2021)
J. Lipid Res. 62:100105 (2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100105-(2021)
The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans. In studies with C57BL/6NCrl mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27187f8e7883d9974250f02e58c65888
https://pubmed.ncbi.nlm.nih.gov/34390703
https://pubmed.ncbi.nlm.nih.gov/34390703
Autor:
Luz M. González, Sonia Mota-Zamorano, Guadalupe García-Pino, Enrique Luna, Guillermo Gervasini
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss, Pp 100648-(2020)
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports
Background We aimed to examine whether combined donor/recipient variants in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes may affect outcomes in renal transplantation. Methods A total of 233 donors and their corresponding 307 recipients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d494c481c4809b8553582850715a84
http://www.sciencedirect.com/science/article/pii/S221442692030094X
http://www.sciencedirect.com/science/article/pii/S221442692030094X
Autor:
Katrin Schröder, Norbert Weissmann, Christoph Schürmann, Tim Warwick, Giulia K. Buchmann, Manuela Spaeth, Oliver J. Müller, Ralf P. Brandes, Marcel H. Schulz, Hanjoong Jo
Publikováno v:
Redox Biology
Redox Biology, Vol 37, Iss, Pp 101713-(2020)
Redox Biology, Vol 37, Iss, Pp 101713-(2020)
Objective Oxidative stress is a risk factor for atherosclerosis. NADPH oxidases of the Nox family produce ROS but their contribution to atherosclerosis development is less clear. Nox2 promotes and Nox4 rather limits atherosclerosis. Although Nox1 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c658962785b9d62d23fd7b9b3f7c5f
http://europepmc.org/articles/PMC7502371
http://europepmc.org/articles/PMC7502371
Autor:
Martin Bidlingmaier, Birgit Rathkolb, Martin Hrabĕ de Angelis, Arne Hinrichs, Werner F. Blum, Sebastian Bultmann, Heinrich Leonhardt, Maik Dahlhoff, Simone Renner, Andreas Blutke, Eckhard Wolf, Barbara Kessler, Andreas Hoeflich, Hiroshi Nagashima, Maren Bernau, Mayuko Kurome, Rüdiger Wanke, Elisabeth Kemter, Armin M. Scholz
Publikováno v:
Molecular Metabolism, Vol 11, Iss, Pp 113-128 (2018)
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128
Objective Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c4a72923ebcdfb6d5ba81facbff4eb
http://www.sciencedirect.com/science/article/pii/S2212877818302114
http://www.sciencedirect.com/science/article/pii/S2212877818302114
Autor:
Henrik Oster, Mareike Bernau, Steffen E. Storck, Claus U. Pietrzik, Riccardo Dore, Alessandro Di Spiezio, Elvira Sonia Sandin, Hendrik Lehnert, Olaf Jöhren, Helge Müller-Fielitz, Walter Mier, Markus Schwaninger
Publikováno v:
Molecular Metabolism, Vol 8, Iss, Pp 13-22 (2018)
Molecular Metabolism
Molecular Metabolism
Objective Leptin is a key hormone in the control of appetite and body weight. Predominantly produced by white adipose tissue, it acts on the brain to inhibit homeostatic feeding and food reward. Leptin has free access to circumventricular organs, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb44b93448048edc0c6f47f7d2037f7
http://www.sciencedirect.com/science/article/pii/S2212877817308621
http://www.sciencedirect.com/science/article/pii/S2212877817308621
Autor:
John J. Kopchick, Marianna Sadagurski, Taylor Landeryou, Carol F. Elias, Richard A. Miller, Gillian Cady, Martin G. Myers, Darleen A. Sandoval, David Garcia-Galiano, Michael Garratt, Nathan Qi
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 5, Pp 393-405 (2017)
Molecular Metabolism, Vol 6, Iss 5, Pp 393-405 (2017)
Objective The GH/IGF-1 axis has important roles in growth and metabolism. GH and GH receptor (GHR) are active in the central nervous system (CNS) and are crucial in regulating several aspects of metabolism. In the hypothalamus, there is a high abunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4895692af3819e052e920ac71c4f457c
http://europepmc.org/articles/PMC5404104
http://europepmc.org/articles/PMC5404104
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 3, Pp 198-209 (2016)
Molecular Metabolism, Vol 5, Iss 3, Pp 198-209 (2016)
Objective Humans and animals exposed to undernutrition (UN) during development often experience accelerated “catch-up” growth when food supplies are plentiful. Little is known about the mechanisms regulating early growth rates. We previously repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cde45139f1e374a007d5fe077f7baa7
Autor:
Miguel López
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 8, Iss C, Pp 211-213 (2018)
Molecular Metabolism, Vol 8, Iss C, Pp 211-213 (2018)
Objectives The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5a0a87f8237986496f3035956a7f14
http://europepmc.org/articles/PMC5985046
http://europepmc.org/articles/PMC5985046
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 867-880 (2015)
Molecular Metabolism
Molecular Metabolism
Objective Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), play a paramount role in the central regulation of energy balance. Despite the substantial body of genetic evidence implicating BDNF- or TrkB-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa4d56ad77b1ca398755cb79b225281
http://www.sciencedirect.com/science/article/pii/S2212877815001568
http://www.sciencedirect.com/science/article/pii/S2212877815001568