Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leos Cmarko"'
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels. Recently, a new heterozygous missense mutation in the CACNA1H gene that en
Externí odkaz:
https://doaj.org/article/f558935862cf41128a425c662d031105
Autor:
Leos Cmarko, Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Tomas Vacik, Lubica Lacinova, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Low-voltage-activated T-type Ca2+ channels are key regulators of neuronal excitability both in the central and peripheral nervous systems. Therefore, their recruitment at the plasma membrane is critical in determining firing activity pattern
Externí odkaz:
https://doaj.org/article/8061933a66364f57af6eede9cdeef15d
Autor:
Vendula Ficelova, Ivana A. Souza, Leos Cmarko, Maria A. Gandini, Robin N. Stringer, Gerald W. Zamponi, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel activity. Previous studies have d
Externí odkaz:
https://doaj.org/article/502f558e4ba041fbbcebcc7be41cd7a7
Autor:
Leos Cmarko, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-3 (2020)
Abstract Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique gatin
Externí odkaz:
https://doaj.org/article/1a636b7a02f849db87a1de4f3d5c1d39
Autor:
Bohumila Jurkovicova-Tarabova, Leos Cmarko, Renata Rehak, Gerald W. Zamponi, Lubica Lacinova, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract The physiological functions controlled by T-type channels are intrinsically dependent on their gating properties, and alteration of T-type channel activity is linked to several human disorders. Therefore, it is essential to develop a clear u
Externí odkaz:
https://doaj.org/article/fd7ca55a414c49ea914616f16a36f01e
Autor:
Quentin Coquerel, Claire Legendre, Jacinthe Frangieh, Stephan De Waard, Jérôme Montnach, Leos Cmarko, Joseph Khoury, Charifat Said Hassane, Dimitri Bréard, Benjamin Siegler, Ziad Fajloun, Harold De Pomyers, Kamel Mabrouk, Norbert Weiss, Daniel Henrion, Pascal Richomme, César Mattei, Michel De Waard, Anne-Marie Le Ray, Christian Legros
Publikováno v:
Molecules, Vol 27, Iss 13, p 4133 (2022)
Voltage-gated Na+ (NaV) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel NaV channel ligands. With the objective of discovering new blockers of NaV channel ligan
Externí odkaz:
https://doaj.org/article/3c3824003c5c472796fb3122b1c94452
Autor:
Leos Cmarko, Sascha R.A. Alles, Marena A. Montera, Aleyah Goins, Karin N. Westlund, Norbert Weiss
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In this brief report, we demonstrate that the Cav3.3 T-type voltage-gated calcium channel subtype is involved in our FRICT-ION model of chronic trigeminal neuropathic pain. We first showed that the Cacna1i gene encoding Cav3.3 is significantly upregu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20337b51b19eb70676125cb68795eacd
https://doi.org/10.1080/19336950.2020.1859248
https://doi.org/10.1080/19336950.2020.1859248
Autor:
Norbert Weiss, Maria A. Gandini, Vendula Ficelova, Gerald W. Zamponi, Leos Cmarko, Ivana A. Souza, Robin N Stringer
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel activity. Previous studies have documented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef707bbd62f34573b5be9f57d0f3780e
http://link.springer.com/article/10.1186/s13041-020-00697-z
http://link.springer.com/article/10.1186/s13041-020-00697-z
Autor:
Norbert Weiss, Leos Cmarko
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-3 (2020)
Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique gating propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef65f97cddfa1db0d663ec942380f13
http://link.springer.com/article/10.1186/s13041-020-00636-y
http://link.springer.com/article/10.1186/s13041-020-00636-y
Autor:
Leos Cmarko, Norbert Weiss, Aisylu S. Gaifullina, Gulshat Burkhanova, Guzel F. Sitdikova, Joanna Lazniewska, Elena Gerasimova, Andriy Tomin, Junting Huang, Paula Rivas-Ramirez, Yuriy Rzhepetskyy, Gerald W. Zamponi
Publikováno v:
Pain. 160:2798-2810
Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db67dee63b6659f1a6d93c0581f684f
https://doi.org/10.1097/j.pain.0000000000001669
https://doi.org/10.1097/j.pain.0000000000001669