Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Leora S. Zalman"'
Autor:
and Rose Ann Ferre, Minerva R. Batugo, Thomas J. Prins, Peter S. Dragovich, Maha B. Kosa, Tove Tuntland, Stephen T. Worland, Fausto Maldonado, Thomas F. Hendrickson, Leora S. Zalman, Lijian Chen, David A. Matthews, Jean-Paul R. Gleeson, Edward L. Brown, Amy K. Patick, Shella A. Fuhrman, James W. Meador, Ru Zhou, Bo Liu, Mark Christopher Guzman, Caroline A. Lee, Sylvie K. Sakata
Publikováno v:
Journal of Medicinal Chemistry. 45:1607-1623
The structure-based design, chemical synthesis, and biological evaluation of various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of a peptidomimetic binding determinant and a
Autor:
Ru Zhou, Theodore O. Johnson, Shella A. Fuhrman, David A. Matthews, Stephen T. Worland, Fausto Maldonado, Amy K. Patick, Leora S. Zalman, Thomas J. Prins, Peter S. Dragovich, Rose Ann Ferre, James W. Meador, Edward L. Brown, Xinjun Hou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:733-738
The structure-based design, chemical synthesis, and biological evaluation of bicyclic 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. An optimized compound is shown to exhibit antiviral activity when tested ag
Autor:
James W. Meador, Helen La, Anna Ettinger, Rachel Ostroff, Barry Polisky, Leora S. Zalman, Amy K. Patick, Steve Worland, Marynette Rihanek
Publikováno v:
Journal of Clinical Virology
Background: More than 100 immunologically distinct serotypes of human rhinoviruses (HRV) have been discovered, making detection of surface exposed capsid antigens impractical. However, the non-structural protein 3C protease (3Cpro) is essential for v
Autor:
Peter S. Dragovich, Ru Zhou, Stephen E. Webber, Thomas J. Prins, Annette K. Kwok, Koji Okano, Shella A. Fuhrman, Leora S. Zalman, Fausto C. Maldonado, Edward L. Brown, James W. Meador, Amy K. Patick, Clifford E. Ford, Mary A. Brothers, Susan L. Binford, David A. Matthews, Rose Ann Ferre, Stephen T. Worland
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:45-48
Tripeptide-derived molecules incorporating C-terminal ketone electrophiles were evaluated as reversible inhibitors of the cysteine-containing human rhinovirus 3C protease (3CP). An optimized example of such compounds displayed potent 3CP inhibition a
Autor:
Tom K Huffaker, Leora S. Zalman, Susan L. Binford, Amy K. Patick, Christopher Pinko, Chen-Chen Kan
Publikováno v:
Antiviral Research. 33:215-218
The nucleotide sequence of the human cytomegalovirus (HCMV) protease gene from two laboratory strains and seven clinical isolates, both ganciclovir-sensitive and -resistant, was examined to determine the genetic variability of the HCMV protease catal
Publikováno v:
Molecular Immunology. 27:533-537
The channels formed by poly C9, C5b-8 and C5b-9 were examined using the liposome swelling assay. By plotting the relative rate of swelling of C5b-8-containing liposomes vs the molecular weight of the sugar solute and by applying the Renkin equation,
Autor:
Amy K. Patick, Mary A. Brothers, Fausto Maldonado, Susan Binford, Oscar Maldonado, Shella Fuhrman, Annkatrin Petersen, George J. Smith, Leora S. Zalman, Leigh Ann Burns-Naas, Jonathan Q. Tran
Publikováno v:
Antimicrobial agents and chemotherapy. 49(6)
(E)-(S)-4-((S)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-pent-4-ynoylamino)-5-((S)-2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester (Compound 1) is a novel, irreversible inhibitor of human rhinovirus (HRV) 3C protease {i
Autor:
George J. Smith, Poe Hirr Hsyu, Leora S. Zalman, Frederick G. Hayden, Ronald B. Turner, Amy K. Patick, Jack M. Gwaltney, Kathy Chi-Burris, Merril Gersten
Publikováno v:
Antimicrobial agents and chemotherapy. 47(12)
Human rhinovirus (HRV) infections are usually self-limited but may be associated with serious consequences, particularly in those with asthma and chronic respiratory disease. Effective antiviral agents are needed for preventing and treating HRV illne
Autor:
Hiep T. Luu, Zhen Ping Wu, Theodore O. Johnson, Jia Liu, Bennett Chaplin Borer, Tove Tuntland, Junhua Tao, Caroline A. Lee, Fausto Maldonado, Amy K. Patick, Sylvie K. Sakata, Thomas J. Prins, Naresh K. Nayyar, Rose Ann Ferre, Michael Mohajeri, Peter W. Rose, Maha B. Kosa, David A. Matthews, Kevin Scott Mcgee, Leora S. Zalman, Steven Lee, Peter S. Dragovich, Ellen Y. Wu, Bo Liu, Shella A. Fuhrman, Ye Hua, Elena Z. Dovalsantos, Paul A. Rejto, Ru Zhou, Mark Christopher Guzman, Ming Guo, Edward L. Brown, Minerva R. Batugo, James W. Meador, Lijian Chen, Andreas Liese, Moran Terence Jarold, Jean-Paul R. Gleeson
Publikováno v:
Journal of medicinal chemistry. 46(21)
The optimization of the pharmacokinetic performance of various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors following oral administration to either beagle dogs or CM-monkeys is described. The molecules described in this w
Autor:
Barry Polisky, Marynette Rhihanek, Thomas J. Prins, Rachel Ostroff, Amy K. Patick, Shella A. Fuhrman, Peter S. Dragovich, Leora S. Zalman, Anna Ettinger, Edward L. Brown, Stephen T. Worland
Publikováno v:
Antiviral research. 61(3)
Human rhinoviruses (HRV) are the main cause of the common cold. Viral replication utilizes the activity of the HRV3C protease (3CP) enzyme [Antimicrob. Agents Chemother. 43 (1999) 2444; Antimicrob. Agents Chemother. 44 (2000) 1236]. Therefore, 3CP is