Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Leora M. Nusblat"'
Publikováno v:
Cancer drug resistance (Alhambra, Calif.)
Aim Improved treatment strategies are desperately needed for eradicating cancer stem cells (CSCs), which drive malignancy and recurrence in glioblastoma multiforme. Hypoxic regions within the tumor microenvironment help maintain and promote the proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e6e29bd639f45a26a0884dfe9631b2
https://doi.org/10.20517/cdr.2019.96
https://doi.org/10.20517/cdr.2019.96
Publikováno v:
Journal of Bioactive and Compatible Polymers. 32:3-16
In this work, pH-sensitive amphiphilic macromolecules are designed to possess good biocompatibility and drug loading while employing an acid-sensitive linkage to trigger drug release at tumor tissues. Specifically, two pH-sensitive amphiphilic macrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1819ab0848b7e1198904d414e00939e7
https://doi.org/10.1177/0883911516643219
https://doi.org/10.1177/0883911516643219
Publikováno v:
Cellular oncology (Dordrecht). 40(5)
Given its extremely poor prognosis, there is a pressing need for an improved understanding of the biology of glioblastoma multiforme (GBM), including the roles of tumor subpopulations that may contribute to their growth rate and therapy resistance. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed577ccce52bdc20870d2f14f3182583
https://pubmed.ncbi.nlm.nih.gov/28643230
https://pubmed.ncbi.nlm.nih.gov/28643230
Autor:
Alexander M. Harmon, Leora M. Nusblat, Kathryn E. Uhrich, Carolyn L. Waite, Sarah M. Sparks, Charles M. Roth
Publikováno v:
Macromolecular Bioscience. 11:1192-1200
New materials that can bind and deliver oligonucleotides such as short interfering RNA (siRNA) without toxicity are greatly needed to fulfill the promise of therapeutic gene silencing. Amphiphilic macromolecules (AMs) were functionalized with linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::692a9b2aa0fea7d7ac831c58cd883de4
https://doi.org/10.1002/mabi.201100064
https://doi.org/10.1002/mabi.201100064
Publikováno v:
European Journal of Cell Biology. 90:205-212
Wiskott-Aldrich Syndrome Protein (WASP) is a hematopoietic cell-specific regulator of Arp2/3-dependent actin polymerization. Despite the presence of the highly homologous N-WASP (neural-WASP), macrophages from WAS patients are devoid of podosomes, ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7828bc87a4c3dbcfe576e80bb44887
https://doi.org/10.1016/j.ejcb.2010.07.012
https://doi.org/10.1016/j.ejcb.2010.07.012
Autor:
John S. Condeelis, Dianne Cox, Leora M. Nusblat, Jean Claude Gevrey, Dan Ishihara, Beth M. Isaac, Athanassios Dovas
Publikováno v:
Experimental Cell Research. 316:3406-3416
Wiskott-Aldrich syndrome protein (WASP) and its homologue neural-WASP (N-WASP) are nucleation promoting factors that integrate receptor signaling with actin cytoskeleton rearrangement. While hematopoietic cells express both WASP and N-WASP, WASP defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d674a11ad2ea74295e1b60c9271eb5
https://doi.org/10.1016/j.yexcr.2010.06.011
https://doi.org/10.1016/j.yexcr.2010.06.011
Autor:
Kathryn E. Uhrich, Nasim Tishbi, Sarah C. Noble, Evan Mintzer, Leora M. Nusblat, Charles M. Roth, Chaya M. Pinson, Li Gu
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society, vol 184, iss 1
The accumulated evidence has shown that lipids and polymers each have distinct advantages as carriers for siRNA delivery. Composite materials comprising both lipids and polymers may present improved properties that combine the advantage of each. Cati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e109f1535bba5141ec51a9ed85d2d0
https://escholarship.org/uc/item/6n27g7p6
https://escholarship.org/uc/item/6n27g7p6
Publikováno v:
2012 38th Annual Northeast Bioengineering Conference (NEBEC).
The inflammatory pathway molecule STAT3 has previously been linked to chemotherapy resistance in glioma tumors. More specifically, we have found that a subset of glioma cells, glioblastoma cancer stem cells (gCSCs) play an integral role in the micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aab46f286e5954c1bd3e9527d761ac2
https://doi.org/10.1109/nebc.2012.6207060
https://doi.org/10.1109/nebc.2012.6207060
Autor:
Sarah M, Sparks, Carolyn L, Waite, Alexander M, Harmon, Leora M, Nusblat, Charles M, Roth, Kathryn E, Uhrich
Publikováno v:
Macromolecular bioscience. 11(9)
New materials that can bind and deliver oligonucleotides such as short interfering RNA (siRNA) without toxicity are greatly needed to fulfill the promise of therapeutic gene silencing. Amphiphilic macromolecules (AMs) were functionalized with linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ffbe982f9c6b6b32f0089f5e94e987a
https://pubmed.ncbi.nlm.nih.gov/21793212
https://pubmed.ncbi.nlm.nih.gov/21793212
Publikováno v:
Journal of Bioactive & Compatible Polymers; Jan2017, Vol. 32 Issue 1, p3-16, 14p