Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Leopoldo Aguilera-Aguirre"'
Autor:
Sarah van Tol, Birte Kalveram, Philipp A Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N Warren, Alexander Bukreyev, Alexander N Freiberg, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010532 (2022)
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously s
Externí odkaz:
https://doaj.org/article/7f5b774b9b474e8c892f3effa42555aa
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110434- (2022)
Summary: Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify fact
Externí odkaz:
https://doaj.org/article/1021a0c2a2e14ca9810fefd46e1864bc
Autor:
Wenjing Hao, Tianyang Qi, Lang Pan, Ruoxi Wang, Bing Zhu, Leopoldo Aguilera-Aguirre, Zsolt Radak, Tapas K. Hazra, Spiros A. Vlahopoulos, Attila Bacsi, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 43-53 (2018)
8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a pro-mutagenic genomic base lesion, but
Externí odkaz:
https://doaj.org/article/e3bcb2fbdc90495ba388b454c3db7000
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Asthma is characterized by reversible airway narrowing, shortness of breath, wheezing, coughing, and other symptoms driven by chronic inflammatory processes, commonly triggered by allergens. In 90% of asthmatics, most of these symptoms can also be tr
Externí odkaz:
https://doaj.org/article/80933b33e95c42678adbc80c705e0559
Autor:
Umesh C S Yadav, Amarjit S Naura, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Hamid A Boulares, William J Calhoun, Kota V Ramana, Satish K Srivastava
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57442 (2013)
Long-term and unresolved airway inflammation and airway remodeling, characteristic features of chronic asthma, if not treated could lead to permanent structural changes in the airways. Aldose reductase (AR), an aldo-sugar and lipid aldehyde metaboliz
Externí odkaz:
https://doaj.org/article/5b4926be28bd441c81554e42fd3225b6
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 6, Pp 1-14 (2020)
Cell Death and Disease, Vol 11, Iss 6, Pp 1-14 (2020)
The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b8f004a752280661671df9d80918f0
http://europepmc.org/articles/PMC7283348
http://europepmc.org/articles/PMC7283348
Autor:
Spiros Vlahopoulos, Zsolt Radak, Attila Bacsi, Bing Zhu, Leopoldo Aguilera-Aguirre, Allan R. Brasier, Xueqing Ba, Ruoxi Wang, Wenjing Hao, Tapas K. Hazra, Lang Pan, Istvan Boldogh, Tianyang Qi
Publikováno v:
Redox Biology, Vol 18, Iss, Pp 43-53 (2018)
Redox Biology
Redox Biology
8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a pro-mutagenic genomic base lesion, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa78aa331af47be4e5a92c2e745491dc
http://www.sciencedirect.com/science/article/pii/S2213231718303562
http://www.sciencedirect.com/science/article/pii/S2213231718303562
Oxidative stress-induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells†
Publikováno v:
Biol Reprod
Term and preterm parturition are associated with oxidative stress (OS)-induced p38 mitogen-activated protein kinase (p38MAPK)-mediated fetal tissue (amniochorion) senescence. p38MAPK activation is a complex cell- and stimulant-dependent process. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5104af27641bcea904698096cd5b20e5
https://doi.org/10.1093/biolre/ioy135
https://doi.org/10.1093/biolre/ioy135
Autor:
Umesh C S Yadav, Leopoldo Aguilera-Aguirre, Kota V Ramana, Istvan Boldogh, Satish K Srivastava
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14440 (2010)
Goblet cell metaplasia that causes mucus hypersecretion and obstruction in the airway lumen could be life threatening in asthma and chronic obstructive pulmonary disease patients. Inflammatory cytokines such as IL-13 mediate the transformation of air
Externí odkaz:
https://doaj.org/article/4bfb322bc00041ceb709b13480ce201d
Autor:
Umesh C S Yadav, Kota V Ramana, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Hamid A Boulares, Satish K Srivastava
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6535 (2009)
The bronchial asthma, a clinical complication of persistent inflammation of the airway and subsequent airway hyper-responsiveness, is a leading cause of morbidity and mortality in critically ill patients. Several studies have shown that oxidative str
Externí odkaz:
https://doaj.org/article/0768bf80cbe044efa09ade9ec0bce648