Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial

Autor: Douwe F. Postma, Cristian Spitoni, Cornelis H. van Werkhoven, Leontine J. R. van Elden, Jan Jelrik Oosterheert, Marc J. M. Bonten

Publikováno v: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background Guidelines recommend macrolides and fluoroquinolones in patients hospitalized with community-acquired pneumonia (CAP), but their use has been associated with cardiac events. We quantified associations between macrolide and fluoroq

Externí odkaz: https://doaj.org/article/5c36937b80a449f6885214263a1b21dd

Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults

Autor: Douwe F, Postma, Cornelis H, van Werkhoven, Leontine J R, van Elden, Steven F T, Thijsen, Andy I M, Hoepelman, Jan A J W, Kluytmans, Wim G, Boersma, Clara J, Compaijen, Eva, van der Wall, Jan M, Prins, Jan J, Oosterheert, Marc J M, Bonten, R E, Jonkers

Publikováno v: Postma, D F, van Werkhoven, C H, van Elden, L J, Thijsen, S F, Hoepelman, A I, Kluytmans, J A J W, Boersma, W G, Compaijen, C J, van der Wall, E, Prins, J M, Oosterheert, J J & Bonten, MJ 2015, ' Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults ', New England Journal of Medicine, vol. 372, no. 14, pp. 1312-1323 . https://doi.org/10.1056/NEJMoa1406330
New England Journal of Medicine, 372(14), 1312. Massachussetts Medical Society
New England journal of medicine, 372(14), 1312-1323. Massachussetts Medical Society
New England Journal of Medicine, 372(14), 1312-1323. Massachussetts Medical Society

BACKGROUND The choice of empirical antibiotic treatment for patients with clinically suspected community-acquired pneumonia (CAP) who are admitted to non–intensive care unit (ICU) hospital wards is complicated by the limited availability of evidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394e2838d7c4e0fa8488f614a31875ad
https://research.vumc.nl/en/publications/c556cecc-e605-4788-afd0-92f2aa104883

Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus

Autor: René Lutter, Koenraad F. van der Sluijs, Leontine J. R. van Elden, Monique Nijhuis, Rob Schuurman, Sandrine Florquin, Tom van der Poll, Henk M. Jansen

Publikováno v: Immunology Letters
Immunology letters, 89(2-3), 201-206. Elsevier

Toll-like receptors (TLR) induce innate immune responses upon stimulation by a wide variety of pathogens. TLR4 has been implicated in innate immunity against respiratory syncytial virus (RSV) by an interaction with the viral envelope fusion (F) prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab872a931809e1f43cb4a72aa9a2bf3
http://europepmc.org/articles/PMC7119665

Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia

Autor: Tom van der Poll, Henk M. Jansen, Rob Schuurman, Takao Shimizu, Satoshi Ishii, Sandrine Florquin, René Lutter, Monique Nijhuis, Koenraad F. van der Sluijs, Leontine J. R. van Elden

Publikováno v: American journal of physiology. Lung cellular and molecular physiology, 290(1), L194-L199. American Physiological Society

Although influenza infection alone may lead to pneumonia, secondary bacterial infections are a much more common cause of pneumonia. Streptococcus pneumoniae is the most frequently isolated causative pathogen during postinfluenza pneumonia. Considerin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21a23cdbae7993ca984dc28f9761279
https://pubmed.ncbi.nlm.nih.gov/16100290

Frequent detection of human coronaviruses in clinical specimens from patients with respiratory tract infection by use of a novel real-time reverse-transcriptase polymerase chain reaction

Autor: Leontine J. R. van Elden, Pauline J. Schipper, Karin A. W. Hendriksen, Jan Jelrik Oosterheert, Anton M. van Loon, Monique Nijhuis, Marian van Kraaij, Andy I. M. Hoepelman, Floris Van Alphen, Rob Schuurman

Publikováno v: The Journal of Infectious Diseases, 189, 652-7
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 189, 4, pp. 652-7

During the past years, human coronaviruses (HCoVs) have been increasingly identified as pathogens associated with more-severe respiratory tract infection (RTI). Diagnostic tests for HCoVs are not frequently used in the routine setting. It is likely t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488614ae0281e0b9a8447af329d55278
http://hdl.handle.net/2066/58442