Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Leonore A Herzenberg"'
Autor:
Darya Y Orlova, Noah Zimmerman, Stephen Meehan, Connor Meehan, Jeffrey Waters, Eliver E B Ghosn, Alexander Filatenkov, Gleb A Kolyagin, Yael Gernez, Shanel Tsuda, Wayne Moore, Richard B Moss, Leonore A Herzenberg, Guenther Walther
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151859 (2016)
Changes in the frequencies of cell subsets that (co)express characteristic biomarkers, or levels of the biomarkers on the subsets, are widely used as indices of drug response, disease prognosis, stem cell reconstitution, etc. However, although the cu
Externí odkaz:
https://doaj.org/article/63f3645cad8e49f5882746bca6d72562
Autor:
Yang Yang, Chunlin Wang, Qunying Yang, Aaron B Kantor, Hiutung Chu, Eliver EB Ghosn, Guang Qin, Sarkis K Mazmanian, Jian Han, Leonore A Herzenberg
Publikováno v:
eLife, Vol 4 (2015)
Processes that define immunoglobulin repertoires are commonly presumed to be the same for all murine B cells. However, studies here that couple high-dimensional FACS sorting with large-scale quantitative IgH deep-sequencing demonstrate that B-1a IgH
Externí odkaz:
https://doaj.org/article/84136b3938e744f4b65826e5869962c2
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35733 (2012)
BACKGROUND:Celastrol, an active compound extracted from the root of the Chinese medicine "Thunder of God Vine" (Tripterygium wilfordii), exhibits anticancer, antioxidant and anti-inflammatory activities, and interest in the therapeutic potential of c
Externí odkaz:
https://doaj.org/article/9aca08932c3c4e79b94202f9cc715fe6
Autor:
Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V. Youngyunpipatkul, James B. Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G. Vilches-Moure, Denong Wang, Michael P. Snyder, Ji-Yang Wang, Jian Han, Leonore A. Herzenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.
Externí odkaz:
https://doaj.org/article/229a32c1fd3d4c71969347ac1499f7d4
Autor:
Debopam Ghosh, Tho D. Pham, Padma P. Nanaware, Deepanwita Sengupta, Lital N. Adler, Caiyun G. Li, Xiao He, Mary E. O'Mara, Aaron B. Kantor, Khoa D. Nguyen, Yang Yang, Laurence C. Eisenlohr, Peter E. Jensen, Leonore A. Herzenberg, Lawrence J. Stern, Scott D. Boyd, Eliver E.B. Ghosn, Elizabeth D. Mellins
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110200- (2022)
Summary: The non-classical Major Histocompatibility Complex class II (MHCII) protein, H2-M, edits peptides bound to conventional MHCII in favor of stable peptide/MHCII (p/MHCII) complexes. Here, we show that H2-M deficiency affects B-1 cell survival,
Externí odkaz:
https://doaj.org/article/bd96043bdd1c4fd6babe806d58bfbeb0
Autor:
Dean W. Felsher, Leonore A. Herzenberg, Howard Y. Chang, Adam S. Adler, Debabrita Deb-Basu, Kondala R. Atkuri, Suma Ray
Supplementary Figures 1-6 from MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbed57cfb283eb89f57490d4a44953c
https://doi.org/10.1158/0008-5472.22364204.v1
https://doi.org/10.1158/0008-5472.22364204.v1
Autor:
Dean W. Felsher, Leonore A. Herzenberg, Howard Y. Chang, Adam S. Adler, Debabrita Deb-Basu, Kondala R. Atkuri, Suma Ray
MYC overexpression is thought to initiate tumorigenesis by inducing cellular proliferation and growth and to be restrained from causing tumorigenesis by inducing cell cycle arrest, cellular senescence, and/or apoptosis. Here we show that MYC can indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5ca1f427feae664226984cdef5ca6a
https://doi.org/10.1158/0008-5472.c.6494072.v1
https://doi.org/10.1158/0008-5472.c.6494072.v1
Autor:
Dean W. Felsher, Leonore A. Herzenberg, Howard Y. Chang, Adam S. Adler, Debabrita Deb-Basu, Kondala R. Atkuri, Suma Ray
Supplementary Figure Legends, Table 1 from MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d333bb8d23d6233a7ec9cdade61697b5
https://doi.org/10.1158/0008-5472.22364210.v1
https://doi.org/10.1158/0008-5472.22364210.v1
Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment
Autor:
Eliver Eid Bou Ghosn, Jeffrey Waters, Megan Phillips, Ryo Yamamoto, Brian R. Long, Yang Yang, Rachel Gerstein, Cheryl A. Stoddart, Hiromitsu Nakauchi, Leonore A. Herzenberg
Publikováno v:
Stem Cell Reports, Vol 6, Iss 1, Pp 137-149 (2016)
B cells are key components of cellular and humoral immunity and, like all lymphocytes, are thought to originate and renew from hematopoietic stem cells (HSCs). However, our recent single-HSC transfer studies demonstrate that adult bone marrow HSCs do
Externí odkaz:
https://doaj.org/article/fc4c0b871c774ddf9749f6cbb2381559
Autor:
Xiaoyou Shi, Wen-Wu Li, Wade S. Kingery, Tian-Zhi Guo, Yang Yang, Leonore A. Herzenberg, Qin Guang, J. David Clark
Publikováno v:
Brain Behav Immun
Emerging evidence suggests that Complex Regional Pain Syndrome (CRPS) is in part a post-traumatic autoimmune disease mediated by an adaptive immune response after limb injuries. We previously observed in a murine tibial fracture model of CRPS that pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ea302aa33542a02ab086cbc5810ee2
https://doi.org/10.1016/j.bbi.2020.05.029
https://doi.org/10.1016/j.bbi.2020.05.029