Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients

Autor: Mariliza Henrique da Silva, Fernanda de Mello Malta, João Renato Rebello Pinho, Andrea G Leite, Camila Malta Romano, Maria Cassia Mendes-Correa, Michele Soares Gomes-Gouvêa, Leonora Z Piccoli, Caroline F Noble, Flair José Carrilho, Gaspar Lisboa Neto

Publikováno v: Journal of Medical Virology. 89:2249-2254

Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870a05f6fc7bd76bac67bc58a0b3661
https://doi.org/10.1002/jmv.24900

HBV carrying drug-resistance mutations in chronically infected treatment-naive patients

Autor: Rosangela Teixeira, Lena Maria Barros, Adalgisa de Souza Paiva Ferreira, Flair José Carrilho, Ariana C. Ferreira, Aline S. O. Kunyoshi, André Castro Lyra, Ana Catharina Seixas S. Nastri, S. R. S. S Conde, Michele Soares Gomes-Gouvêa, Andrea G Leite, Marcio K. Oikawa, Leonora Z Piccoli, Manoel do Carmo Pereira Soares, Jose R. Andrade, Dennis Armando Bertolini, Maria Cassia Mendes-Correa, Dimas A. Kliemann, Rosamar Eulira Fontes Rezende, Josiane Galvan, Luciano Vieira de Araújo, João Renato Rebello Pinho

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

BackgroundNucleoside/nucleotide analogue (NA) treatment causes selection pressure for HBV strains carrying mutations conferring NA resistance. Drug-resistance mutations occur in the reverse transcriptase (RT) region of the HBV polymerase gene and spo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16840f501367fe54408b2c23fc25e1be
https://pubmed.ncbi.nlm.nih.gov/25624410