Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Leonor Sánchez-Busó"'
Autor:
Silvia Argimón, Corin A. Yeats, Richard J. Goater, Khalil Abudahab, Benjamin Taylor, Anthony Underwood, Leonor Sánchez-Busó, Vanessa K. Wong, Zoe A. Dyson, Satheesh Nair, Se Eun Park, Florian Marks, Andrew J. Page, Jacqueline A. Keane, Stephen Baker, Kathryn E. Holt, Gordon Dougan, David M. Aanensen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Whole genome sequencing data are increasingly becoming routinely available but generating actionable insights is challenging. Here, the authors describe Pathogenwatch, a web tool for genomic surveillance of S. Typhi, and demonstrate its use for antim
Externí odkaz:
https://doaj.org/article/8067dd1bb7af437ca15c3973913ab4f9
Autor:
Leonor Sánchez-Busó, Corin A. Yeats, Benjamin Taylor, Richard J. Goater, Anthony Underwood, Khalil Abudahab, Silvia Argimón, Kevin C. Ma, Tatum D. Mortimer, Daniel Golparian, Michelle J. Cole, Yonatan H. Grad, Irene Martin, Brian H. Raphael, William M. Shafer, Katy Town, Teodora Wi, Simon R. Harris, Magnus Unemo, David M. Aanensen
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Antimicrobial-resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health, as strains resistant to at least one of the two last-line antibiotics used in empiric therapy of gonorrhoea, ceftriaxone and azithromycin, h
Externí odkaz:
https://doaj.org/article/17558a4a64b74ac2af5592b9c90c68ff
Autor:
Kevin C. Ma, Tatum D. Mortimer, Marissa A. Duckett, Allison L. Hicks, Nicole E. Wheeler, Leonor Sánchez-Busó, Yonatan H. Grad
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The mechanisms underlying resistance of Neisseria gonorrhoeae to the antibiotic azithromycin are incompletely understood. Here, Ma et al. conduct a conditional genome-wide association study to identify new resistance mutations and experimentally conf
Externí odkaz:
https://doaj.org/article/f01d8464f9184f78b8e150f301aabff4
Autor:
Kevin C. Ma, Tatum D. Mortimer, Allison L. Hicks, Nicole E. Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel H. F. Rubin, Yi Wang, Deborah A. Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. Grad
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations
Externí odkaz:
https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610
Autor:
Katy Town, Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, Gwenda Hughes
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 3, Pp 505-515 (2020)
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global concern. Phylogenetic analyses resolve uncertainties regarding genetic relatedness of isolates with identical phenotypes and inform whether AMR is due to new mutations and clonal exp
Externí odkaz:
https://doaj.org/article/203cb38ec437479ea1a9b1fb77eeb01f
Autor:
Daniel Golparian, Simon R. Harris, Leonor Sánchez-Busó, Steen Hoffmann, William M. Shafer, Stephen D. Bentley, Jörgen S. Jensen, Magnus Unemo
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Multidrug-resistant Neisseria gonorrhoeae strains are prevalent, threatening gonorrhoea treatment globally, and understanding of emergence, evolution, and spread of antimicrobial resistance (AMR) in gonococci remains limited. We d
Externí odkaz:
https://doaj.org/article/78937129ea5b44aa946337dd26a910bf
Autor:
Allison L Hicks, Nicole Wheeler, Leonor Sánchez-Busó, Jennifer L Rakeman, Simon R Harris, Yonatan H Grad
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007349 (2019)
Prediction of antibiotic resistance phenotypes from whole genome sequencing data by machine learning methods has been proposed as a promising platform for the development of sequence-based diagnostics. However, there has been no systematic evaluation
Externí odkaz:
https://doaj.org/article/3e5ab5d53c7942a1ab9339a65098e286
Autor:
Isaac Darko Otchere, Andries J van Tonder, Adwoa Asante-Poku, Leonor Sánchez-Busó, Mireia Coscollá, Stephen Osei-Wusu, Prince Asare, Samuel Yaw Aboagye, Samuel Acquah Ekuban, Abdallah Iddrisu Yahayah, Audrey Forson, Akosua Baddoo, Clement Laryea, Julian Parkhill, Simon R Harris, Sebastien Gagneux, Dorothy Yeboah-Manu
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0209395 (2019)
BACKGROUND:Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M. bovis strains with hyper-virulence, MDR-TB and disseminated disease makes it imperative to understand
Externí odkaz:
https://doaj.org/article/d624ea67789c4e3e82f8e21c5517c477
Autor:
Iliana Guardiola-Avila, Leonor Sánchez-Busó, Evelia Acedo-Félix, Bruno Gomez-Gil, Manuel Zúñiga-Cabrera, Fernando González-Candelas, Lorena Noriega-Orozco
Publikováno v:
Microorganisms, Vol 9, Iss 1, p 191 (2021)
Vibrio mimicus is an emerging pathogen, mainly associated with contaminated seafood consumption. However, little is known about its evolution, biodiversity, and pathogenic potential. This study analyzes the pan-, core, and accessory genomes of nine V
Externí odkaz:
https://doaj.org/article/5dabe45a21954507b511c35831dbf927
Autor:
Sophia David, Leonor Sánchez-Busó, Simon R Harris, Pekka Marttinen, Christophe Rusniok, Carmen Buchrieser, Timothy G Harrison, Julian Parkhill
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007116 (2017)
[This corrects the article DOI: 10.1371/journal.pgen.1006855.].
Externí odkaz:
https://doaj.org/article/8b9c6299d3704f31897744be32456f84