Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Leonor Rivera-Calimlim"'
Publikováno v:
Clinical Pharmacology & Therapeutics. 17:253-257
Twenty-nine healthy young male volunteers were screened by history, physical examination, urinalysis, 24 different blood tests, and electrocardiography for admission to a Phase I drug study. The protocol submitted to, and approved by, the FDA listed
Publikováno v:
Journal of Asthma. 23:113-122
The bioavailability and pharmacological effects of slow-release preparations oxtriphylline (Choledyl SA) and anhydrous theophylline (Theo-Dur) were compared in a single-blind, randomized, crossover study in 10 normal men. Subjects were administered t
Autor:
Leonor Rivera-Calimlim
Publikováno v:
British Journal of Pharmacology. 56:301-305
1 The absorption and tissue distribution of orally administered [14C]-chlorpromazine (CPZ) were compared in trihexyphenidyl (THP; Artane)-treated and control rats. 2 Total radioactivity (CPZ) in the plasma and brain of rats treated with THP was signi
Publikováno v:
Psychopharmacology. 73:355-358
Low chloropromazine (CPZ) levels have been measured in chronically treated schizophrenics. We tested six such patients to determine whether a 2-week CPZ-free period (drug holiday) would improve plasma CPZ levels. We also monitored psychiatric symptom
Autor:
Leonor Rivera-Calimlim
Publikováno v:
Therapeutic Drug Monitoring. 4:41-50
Chlorpromazine (CPZ) therapeutic drug monitoring is beset by inconclusive and controversial evidence on the positive correlation of plasma CPZ concentration and psychiatric improvement. Failure to establish meaningful correlation between plasma conce
Publikováno v:
Clinical Pharmacology & Therapeutics. 23:451-455
The interaction of lithium and chlorpromazine (CPZ) was studied in healthy volunteers in a randomized crossover study. Each subject ingested two doses of CPZ (100 mg) as the liquid concentrate: (1) without concurrent lithium therapy and (2) after a 7
Autor:
Leonor Rivera-Calimlim, Allen J. Rubin, Charlyne Miller, Ira Shoulson, Roger Kurlan, Allan Clarke
Publikováno v:
Annals of Neurology. 20:262-265
The pathogenesis of on-off motor fluctuations in parkinsonism remains incompletely understood, but slowed or erratic gastric emptying of orally administered levodopa may be involved. In 3 patients with resistant on-off fluctuations, direct duodenal c
Publikováno v:
British Journal of Pharmacology. 95:77-82
1. Measurements of brain acetylcholine (ACh) synthesis from precursor [14C]-pyruvate, pantothenic acid (PA) concentration in the brain, and blood ethanol (EtOH) concentration were made in rats treated with either ethanol (5-6 g kg-1 body wt daily) al
Autor:
Leonor Rivera-Calimlim
Publikováno v:
British Journal of Pharmacology. 50:259-263
1 The absorption, tissue distribution, and metabolism of [14C]-O-methyldopa were compared with those of [14C]-L-DOPA after oral administration to rats. 2 Total radioactivity in the plasma and brain of rats treated with [14C]-O-methyldopa was signific
Publikováno v:
Biochemical Pharmacology. 27:2781-2786
In a previous study, it was observed that chlorpromazine (CPZ) inhibited the transport of l -methionine in the rat intestine. The present experiments were designed to delineate the possible mechanism of this effect. Pre-incubation studies with CPZ de