Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Leonor Pinilla"'
Autor:
Miguel A. Sánchez-Garrido, Víctor Serrano-López, Francisco Ruiz-Pino, María Jesús Vázquez, Andrea Rodríguez-Martín, Encarnación Torres, Inmaculada Velasco, Ana Belén Rodríguez, Eduardo Chicano-Gálvez, Marina Mora-Ortiz, Claes Ohlsson, Matti Poutanen, Leonor Pinilla, Francisco Gaytán, Jonathan D. Douros, Bin Yang, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Manuel Tena-Sempere
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous condition, defined by oligo-/anovulation, hyper-androgenism and/or polycystic ovaries. Metabolic complications are common in patients suffering PCOS, including obesity, insulin resistance a
Externí odkaz:
https://doaj.org/article/e9aa6128690c4c71b7909dd30b6ade0a
Autor:
Juan Roa, Miguel Ruiz-Cruz, Francisco Ruiz-Pino, Rocio Onieva, Maria J. Vazquez, Maria J. Sanchez-Tapia, Jose M. Ruiz-Rodriguez, Veronica Sobrino, Alexia Barroso, Violeta Heras, Inmaculada Velasco, Cecilia Perdices-Lopez, Claes Ohlsson, Maria Soledad Avendaño, Vincent Prevot, Matti Poutanen, Leonor Pinilla, Francisco Gaytan, Manuel Tena-Sempere
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of repre
Externí odkaz:
https://doaj.org/article/6b753545ed844d9184dfd67bb491e30f
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.
Autor:
Violeta Heras, Susana Sangiao-Alvarellos, Maria Manfredi-Lozano, María J Sanchez-Tapia, Francisco Ruiz-Pino, Juan Roa, Maribel Lara-Chica, Rosario Morrugares-Carmona, Nathalie Jouy, Ana P Abreu, Vincent Prevot, Denise Belsham, Maria J Vazquez, Marco A Calzado, Leonor Pinilla, Francisco Gaytan, Ana C Latronico, Ursula B Kaiser, Juan M Castellano, Manuel Tena-Sempere
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000532 (2019)
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key
Externí odkaz:
https://doaj.org/article/ef93c7a3add44a31bc7144e1863b1fe4
Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
Autor:
Maria Manfredi-Lozano, Juan Roa, Francisco Ruiz-Pino, Richard Piet, David Garcia-Galiano, Rafael Pineda, Aurora Zamora, Silvia Leon, Miguel A. Sanchez-Garrido, Antonio Romero-Ruiz, Carlos Dieguez, Maria Jesus Vazquez, Allan E. Herbison, Leonor Pinilla, Manuel Tena-Sempere
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 844-857 (2016)
Objective: Puberty is a key developmental phenomenon highly sensitive to metabolic modulation. Worrying trends of changes in the timing of puberty have been reported in humans. These might be linked to the escalating prevalence of childhood obesity a
Externí odkaz:
https://doaj.org/article/5cc37d0b03aa4825aef4cba9b188774d
Autor:
María J. Vázquez, Marta G. Novelle, Francisca Rodríguez-Pacheco, Ricardo Lage, Luis Varela, Miguel López, Leonor Pinilla, Manuel Tena-Sempere, Carlos Diéguez
Publikováno v:
Cells, Vol 9, Iss 9, p 1940 (2020)
GH (growth hormone) secretion/action is modulated by alterations in energy homeostasis, such as malnutrition and obesity. Recent data have uncovered the mechanism by which hypothalamic neurons sense nutrient bioavailability, with a relevant contribut
Externí odkaz:
https://doaj.org/article/8c02a2d0ed9448cda5dfcb5bb7a78a65
Autor:
Cecilia Perdices-Lopez, María S. Avendaño, Alexia Barroso, Francisco Gaytán, Francisco Ruiz-Pino, Maria J. Vázquez, Silvia Leon, Yong Bhum Song, Veronica Sobrino, Violeta Heras, Antonio Romero-Ruiz, Juan Roa, Federico Mayor, Cristina Murga, Leonor Pinilla, Ursula B. Kaiser, Manuel Tena-Sempere
Publikováno v:
Metabolism
BACKGROUND: Perturbations in the timing of puberty, with potential adverse consequences in later health, are increasingly common. The underlying neurohormonal mechanisms are unfolded, but nutritional alterations are key contributors. Efforts to unvei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac73583050fcedda2a4a498afd18cef
https://europepmc.org/articles/PMC10283027/
https://europepmc.org/articles/PMC10283027/
Autor:
C. Dieguez, Alfonso Paredes, E. Torres, Rafael Pineda, Heras, Juan Carlos Roa, Ismael Velasco, María Jesús Vázquez, F Gaytan, M. Tena-Sempere, Daniela Fernandois, Rubio M, Francisco Ruiz-Pino, María S. Avendaño, Núria Casals, Elvira Rodríguez-Vázquez, Denise D. Belsham, Miguel López, Juan M. Castellano, Leonor Pinilla
Publikováno v:
Yearbook of Paediatric Endocrinology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb0902e8dbe79b1218373bd9a783af0
https://doi.org/10.1530/ey.18.7.10
https://doi.org/10.1530/ey.18.7.10
Autor:
Juan Roa Rivas, Rafael Pineda Reyes, Juan Manuel Castellano Rodríguez, Leonor Pinilla Rodríguez, Manuel Tena Sempere, Francisco Gaytán Luna
Publikováno v:
Revista de Innovación y Buenas Prácticas Docentes. 8:116-123
El presente proyecto ha consistido en la implantación de un sistema de gamificación de preguntas y respuestas en clase con el objetivo de mejorar la motivación y el compromiso de los alumnos con el aprendizaje en las asignaturas del área de Fisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9bc56497fb5992c9445719f1e6b7bb
https://doi.org/10.21071/ripadoc.v8i4.12330
https://doi.org/10.21071/ripadoc.v8i4.12330
Autor:
Rafael Pineda, David Garcia-Galiano, María Jesús Vázquez, Patricia Seoane-Collazo, Heras, Noelia Martínez-Sánchez, Alexia Barroso, Francisco Ruiz-Pino, Juan M. Castellano, Manuel Tena-Sempere, T. Ilhan, C. Dieguez, Matti Poutanen, Leonor Pinilla, F Gaytan, Juan Carlos Roa, Miguel López, S. Leon, anfredi-Lozano M
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(45):E10758-E10767
Conditions of metabolic distress, from malnutrition to obesity, impact, via as yet ill-defined mechanisms, the timing of puberty, whose alterations can hamper later cardiometabolic health and even life expectancy. AMP-activated protein kinase (AMPK),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5860a10f9e50e5dfce37f53c298b9674
https://doi.org/10.1073/pnas.1802053115
https://doi.org/10.1073/pnas.1802053115
Autor:
Silvia Leon, Carlos Dieguez, Alexia Barroso, María Jesús Vázquez, Maria Manfredi-Lozano, Daniel Beiroa, Rubén Nogueiras, Leonor Pinilla, Juan Roa, Violeta Heras, Manuel Tena-Sempere, Inmaculada Velasco, Antonio Romero-Ruiz, Miguel A. Sánchez-Garrido, Francisco Ruiz-Pino
Publikováno v:
Metabolism. 87:87-97
Background RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of gonadotropin-inhibiting hormone, operates as inhibitory signal for the reproductive axis. Recently, RFRP-3 has been also suggested to stimulate feeding, and therefore might con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aa7f29c8f9fa26829468821e5c11a1
https://doi.org/10.1016/j.metabol.2018.07.003
https://doi.org/10.1016/j.metabol.2018.07.003