Detecting changes in the caenorhabditis elegans intestinal environment using an engineered bacterial biosensor

Autor: Geraint M.H. Thomas, Filipe Cabreiro, Evgeniy R. Galimov, Leonor M. Quintaneiro, Luca Rosa, Chris P. Barnes, Jack W. Rutter, Tanel Ozdemir

Caenorhabditis elegans has become a key model organism within biology. In particular, the transparent gut, rapid growing time, and ability to create a defined gut microbiota make it an ideal candidate organism for understanding and engineering the ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbdaf698e914f1771d1406fb90a4126
http://hdl.handle.net/10044/1/76574

FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis

Autor: Laura Chan Wah Hak, Emmanuel Boucrot, Antonio P A Ferreira, Safa Lucken-Ardjomande Häsler, Matthias Krause, Shaheen Khan, Harvey T. McMahon, Ah-Lai Law, Leonor M. Quintaneiro, Ilaria Di Meglio

Publikováno v: Chan Wah Hak, L, Khan, S, Di Meglio, I, Law, A, Lucken-ardjomande Häsler, S, Quintaneiro, L M, Ferreira, A P A, Krause, M, Mcmahon, H T & Boucrot, E 2018, ' FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis ', Nature Cell Biology, vol. 20, no. 9, pp. 1023-1031 . https://doi.org/10.1038/s41556-018-0146-8

Endocytosis mediates the cellular uptake of micronutrients and the turnover of plasma membrane proteins. Clathrin-mediated endocytosis is the major uptake pathway in resting cells1, but several clathrin-independent endocytic routes exist in parallel2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6554cd23df728c19c5ddc6af078791da
https://kclpure.kcl.ac.uk/en/publications/dcc2d23d-2f1c-40ef-b9e3-241a5bdda649

Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans

Autor: Timothy A, Scott, Leonor M, Quintaneiro, Povilas, Norvaisas, Prudence P, Lui, Matthew P, Wilson, Kit-Yi, Leung, Lucia, Herrera-Dominguez, Sonia, Sudiwala, Alberto, Pessia, Peter T, Clayton, Kevin, Bryson, Vidya, Velagapudi, Philippa B, Mills, Athanasios, Typas, Nicholas D E, Greene, Filipe, Cabreiro

Publikováno v: Cell

Summary Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d2dc8a3b6eba239535c64036cde2bef
https://pubmed.ncbi.nlm.nih.gov/28431245